Tag: Inhibitor|Inducer

For research use only. We do not sell to patients. Tacrolimus-13C,d2 CAS No. : 1356841-89-8 Biological Activity：Tacrolimus-13C,D2 (FK506-13C,D2) is a 13C-labeled and deuterium labeled Tacrolimus. Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties. Research […]

For research use only. We do not sell to patients. Pan-Trk-IN-3 Biological Activity：Pan-Trk-IN-3 (Compound 11g) is a potent inhibitor of pan-Trk and their drug-resistant mutants with IC50 values of 2, 3, 2, 21, 26, 5, 7 and 6 nM against TrkA, TrkB, TrkC, TrkAG595R, TrkAG667C, TrkAG667S, TrkAF589L and TrkCG623R, respectively. Pan-Trk-IN-3 displays excellent antitumor activity […]

For research use only. We do not sell to patients. ZLMT-12 Biological Activity：ZLMT-12 (compound 35), tacrine derivatives, is a potent, orally active CDK2/9 inhibitor with IC50 values of 0.002 and 0.011 μM for CDK9 and CDK2, respectively. ZLMT-12 has a weak inhibitory effect on AChE (IC50=19.023 μM) and BChE (IC50=2.768 μM). ZLMT-12 has low toxicity […]

For research use only. We do not sell to patients. CNDAC CAS No. : 135598-68-4 Biological Activity：CNDAC is a metabolite of the orally active agent Sapacitabine (HY-16445), and a nucleoside analog. CNDAC induces DNA damage and apoptosis[2]. Research Area：Cancer Targets：Drug Metabolite|Nucleoside Antimetabolite/Analog|DNA/RNA Synthesis|Apoptosis Related Small Molecules:Physalin A;Nicotinamide N-oxide;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;m7GpppCpG;Ametantrone;BJE6-106;ddCTP trisodium;7-TFA-ap-7-Deaza-dA;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor 3;Xevinapant;Mangiferin;Cambinol […]

For research use only. We do not sell to patients. Temsirolimus-d3 Biological Activity：Temsirolimus-d3 (CCI-779-d3) is the deuterium labeled Temsirolimus. Temsirolimus is an inhibitor of mTOR with an IC50 of 1.76 μM. Temsirolimus activates autophagy and prevents deterioration of cardiac function in animal model[8]. Research Area：Cancer Targets：Autophagy|mTOR|Apoptosis Related Small Molecules:D-α-Hydroxyglutaric acid disodium;Physalin A;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;BJE6-106;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase […]

For research use only. We do not sell to patients. PIM-1/HDAC-IN-1 Biological Activity：PIM-1/HDAC-IN-1 (compound 4d) is a PIM-1 inhibitor, with an IC50 of 343.87 nM. PIM-1/HDAC-IN-1 has strong inhibitory activity and selectivity against HDAC 1 and HDAC 6, with IC50 values of 63.65 and 62.39 nM, respectively. PIM-1/HDAC-IN-1 exhibits apoptosis inducing potential in MCF-7 cell […]

For research use only. We do not sell to patients. (2E)-OBAA CAS No. : 221632-26-4 Biological Activity：(2E)-OBAA is a potent phospholipase A2 (PLA2) inhibitor, with an IC50 of 70 nM. (2E)-OBAA induces apoptosis of HUVEC cells. (2E)-OBAA blocks Melittin-induced Ca2+ influx in Trypanosoma brucei, with an IC50 of 0.4 μM[2][3][4]. Research Area：Inflammation/Immunology Targets：Apoptosis|Phospholipase Related Small […]

For research use only. We do not sell to patients. Reveromycin A CAS No. : 134615-37-5 Biological Activity：Reveromycin A, a benzoquinoid antibiotic isolated from the genus Streptomyces, is a selective inhibitor of protein synthesis in eukaryotic cells. Reveromycin A inhibits bone resorption by inducing apoptosis specifically in osteoclasts. Reveromycin A has antiproliferative activity against tumor […]

For research use only. We do not sell to patients. Apigenin CAS No. : 520-36-5 Biological Activity：Apigenin (4′,5,7-Trihydroxyflavone) is a competitive CYP2C9 inhibitor with a Ki of 2 μM. Research Area：Inflammation/Immunology|Cancer Targets：Autophagy|Endogenous Metabolite|Cytochrome P450 Related Screening Libraries:Natural Product Library Plus;Bioactive Compound Library Plus;Immunology/Inflammation Compound Library;Metabolism/Protease Compound Library;Natural Product Library;Anti-Cancer Compound Library;Autophagy Compound Library;Anti-Aging Compound Library;Antioxidant […]

For research use only. We do not sell to patients. c-Met/HDAC-IN-2 CAS No. : 2740495-53-6 Biological Activity：c-Met/HDAC-IN-2 is a highly potent c-Met and HDAC dual inhibitor with IC50s of 18.49 nM and 5.40 nM for HDAC1 and c-Met, respectively. c-Met/HDAC-IN-2 has antiproliferative activities against certain cancer cell lines. c-Met/HDAC-IN-2 can cause G2/M-phase arrest and induce […]