Tag: Inhibitor|Inducer

For research use only. We do not sell to patients. Tubulin polymerization-IN-28 CAS No. : 2481404-89-9 Biological Activity：Tubulin polymerization-IN-28 (compound-4) is a microtubule protein polymerization inhibitor with highly selective anticancer activity. Tubulin polymerization-IN-28 can be activated by NQO1 and effectively release combretastatin A-4 to kill tumor cells. Tubulin polymerization-IN-28 can induce cell apoptosis and be […]

For research use only. We do not sell to patients. 23-Hydroxybetulinic acid CAS No. : 85999-40-2 Biological Activity：23-hydroxybetulinic acid is one of the bioactive components responsible for its anticancer activity. In vitro: 23-hydroxybetulinic acid also shows different proliferation inhibitory activity against B16, HeLa, and HUVEC, with the IC50 value of 78.5, 80, and 94.8 uM, […]

For research use only. We do not sell to patients. Eribulin mesylate CAS No. : 441045-17-6 Biological Activity：Eribulin mesylate (E7389 mesylate) is a microtubule targeting agent that is used for the research of metastatic breast cancer. Eribulin mesylate inhibits the proliferation of cancer cells by binding microtubule proteins and microtubules. Research Area：Cancer Targets：Microtubule/Tubulin|Apoptosis Related Screening […]

For research use only. We do not sell to patients. (Rac)-Antineoplaston A10 CAS No. : 77658-84-5 Biological Activity：(rac)-Antineoplaston A10 is the racemate of Antineoplaston A10. Antineoplaston A10 is a Ras inhibitor potentially for the treatment of glioma, lymphoma, astrocytoma and breast cancer. Research Area：Cancer Targets：Apoptosis|Ras Related Small Molecules:Physalin A;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;BJE6-106;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor 3;Xevinapant;Mangiferin;Cambinol;Antioxidant […]

For research use only. We do not sell to patients. Tubulin/HDAC-IN-1 CAS No. : 2413587-26-3 Biological Activity：Tubulin/HDAC-IN-1 is a dual tubulin and HDAC-IN-1 inhibitor through CH/π interaction with tubulin and hydrogen bond interaction with HDAC8. Tubulin/HDAC-IN-1 inhibits tubulin polymerization and selectively inhibits HDAC8 (IC50: 150 nM). Tubulin/HDAC-IN-1 has cytotoxicity against various human cancer cells, also […]

For research use only. We do not sell to patients. Girinimbine CAS No. : 23095-44-5 Biological Activity：Girinimbine (Girinimbin) is a carbazole alkaloid with a variety of biological effects. Girinimbine can induce apoptosis, and has antitrypanosomal, antiplatelet activity, antibacterial activity, anti-inflammatory, antioxidant and antitumor activities[2][3]. Research Area：Cancer|Infection|Inflammation/Immunology Targets：Parasite|Bacterial|Apoptosis Related Screening Libraries:Natural Product Library Plus;Bioactive Compound Library […]

For research use only. We do not sell to patients. S65487 CAS No. : 1644600-79-2 Biological Activity：S65487 (VOB560), a potent and selective BCL-2 inhibitor, is a prodrug of S55746. S65487 is also active on BCL-2 mutations, such as G101V and D103Y. S65487 has poor affinity with MCL-1, BFL-1 and BCL-XL. S65487 induces apoptosis and has […]

For research use only. We do not sell to patients. CDK-IN-9 Biological Activity：CDK-IN-9 (compound 24) is a potent CDK inhibitor, also as a molecular glue inducing an interaction between CDK12 and DDB1, with an IC50 values of 4 nM for CDK2/E. CDK-IN-9 leads to polyubiquitination of cyclin K and its subsequent degradation. CDK-IN-9 induce apoptosis […]

For research use only. We do not sell to patients. Apremilast-d5 CAS No. : 1258597-47-5 Biological Activity：Apremilast D5 (CC-10004 D5) is a deuterium labeled Apremilast. Apremilast is an orally available inhibitor of type-4 cyclic nucleotide phosphodiesterase (PDE-4) with an IC50 of 74 nM. Apremilast inhibits TNF-α release by lipopolysaccharide (LPS) with an IC50 of 104 […]

For research use only. We do not sell to patients. VPC-70063 CAS No. : 13571-44-3 Biological Activity：VPC-70063 is a potent Myc-Max inhibitor with an IC50 value of 8.9 μM for Myc-Max transcriptional activity inhibition. VPC-70063 reduces UBE2C promotor activity and AR-V7 levels, and induces PARP cleavage. VPC-70063 induces apoptosis and blocks Myc-Max interactions with DNA. […]