Tag: Inhibitor|Agonist

For research use only. We do not sell to patients. Zidovudine CAS No. : 30516-87-1 Biological Activity：Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection. Zidovudine increases CRISPR/Cas9-mediated editing frequency. Research Area：Infection|Cancer Targets：CRISPR/Cas9|HIV Related Screening Libraries:Covalent Screening Library Plus;Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound […]

For research use only. We do not sell to patients. Ertiprotafib CAS No. : 251303-04-5 Biological Activity：Ertiprotafib is an inhibitor of PTP1B, IkB kinase β (IKK-β), and a dual PPARα and PPARβ agonist, with an IC50 of 1.6 μM for PTP1B, 400 nM for IKK-β, an EC50 of ~1 μM for PPARα/PPARβ. Research Area：Metabolic Disease […]

For research use only. We do not sell to patients. DPP-4/GPR119 modulator 2 CAS No. : 2010927-65-6 Biological Activity：DPP-4/GPR119 modulator 2 (Compound 20i) is a dipeptidyl peptidase IV (DPP-IV) inhibitor and GPR119 agonist with an IC50 of 0.22 µM for DPP-IV and an EC50 of 0.95 µM for GPR119. DPP-4/GPR119 modulator 2 can be used […]

For research use only. We do not sell to patients. Methylprednisolone-d3 Biological Activity：Methylprednisolone-d3 (U 7532-d3) is the deuterium labeled Methylprednisolone. Methylprednisolone is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels[3]. Research Area：Cancer|Infection|Endocrinology|Inflammation/Immunology Targets：Autophagy|Glucocorticoid Receptor|SARS-CoV Related Small Molecules:Deflazacort-D5;SARS-CoV-2-IN-33;GRL-0496;Grazoprevir potassium salt;SARS-CoV-2-IN-19;Molnupiravir;SARS-CoV-2 Mpro-IN-3;MM3122;Ketotifen fumarate;SARS-CoV-2-IN-16;Thapsigargin;INSCoV-614(1B);Anti-SARS-CoV-2 Spike […]

For research use only. We do not sell to patients. OPC-14523 hydrochloride CAS No. : 145969-31-9 Biological Activity：OPC-14523 hydrochloride is an orally active sigma and 5-HT1A receptor agonist, with high affinity for sigma receptors (σ1/2 IC50=47/56 nM), the 5-HT1A receptor (IC50=2.3 nM), and the 5-HT transporter (IC50=80 nM). OPC-14523 hydrochloride shows antidepressant-like activity[2]. Research Area：Neurological […]

For research use only. We do not sell to patients. Cyprodinil CAS No. : 121552-61-2 Biological Activity：Cyprodinil is an anilinopyrimidine broad-spectrum fungicide that inhibits the biosynthesis of methionine in phytopathogenic fungi. Cyprodinil inhibits mycelial cell growth of B. cinerea, P. herpotrichoides, and H. oryzae on amino acid-free media (IC50s=0.44, 4.8, and 0.03 µM, respectively). Cyprodinil […]

For research use only. We do not sell to patients. Gramine CAS No. : 87-52-5 Biological Activity：Gramine (Donaxine) is a natural alkaloid isolated from giant reed[2], acts as an active adiponectin receptor (AdipoR) agonist, with IC50s of 3.2 and 4.2 µM for AdipoR2 and AdipoR1, respectively. Gramine is also a human and mouse β2-Adrenergic receptor […]

For research use only. We do not sell to patients. DPN CAS No. : 1428-67-7 Biological Activity：DPN (Diarylpropionitrile) is a non-steroidal estrogen receptor β (ERβ) selective ligand, with an EC50 of 0.85 nM. DPN has neuroprotective effects in a number of neurological diseases[2]. Research Area：Neurological Disease Targets：Autophagy|Estrogen Receptor/ERR|Apoptosis Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound […]

For research use only. We do not sell to patients. Pioglitazone potassium CAS No. : 1266523-09-4 Biological Activity：Pioglitazone (U 72107) potassium is an orally active and selective PPARγ (peroxisome proliferator-activated receptor) agonist with high affinity binding to the PPARγ ligand-binding domain with EC50 of 0.93 μM and 0.99 μM for human and mouse PPARγ, respectively. […]

For research use only. We do not sell to patients. L-Glutamine CAS No. : 56-85-9 Biological Activity：L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells[2]. Research Area：Metabolic Disease|Cancer Targets：Ferroptosis|mGluR|Endogenous Metabolite Related Screening Libraries:Natural […]