Tag: Inducer|Inhibitor

For research use only. We do not sell to patients. ACT001 CAS No. : 1582289-91-5 Biological Activity：ACT001 is an orally active PAI-1 inhibitor by inhibiting the phosphorylation of PI3K and AKT. ACT001 inhibits the phosphorylation of STAT3 and PD-L1 expression by directly binding to STAT3. ACT001, a fumarate salt form of DMAMCL (a prodrug of […]

For research use only. We do not sell to patients. Flubendazole CAS No. : 31430-15-6 Biological Activity：Flubendazole is a safe and efficacious anthelmintic drug, which is widely used for anthelmintic to human, rodents and ruminants. Flubendazole exerts anticancer activities by mechanisms including inhibition of microtubule function. Flubendazole induces p53-mediated apoptosis and arrests G2/M cell cycle[2]. […]

For research use only. We do not sell to patients. Stavudine sodium CAS No. : 134624-73-0 Biological Activity：Stavudine (d4T) sodium is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Stavudine sodium has activity against HIV-1 and HIV-2. Stavudine sodium also inhibits the replication of mitochondrial DNA (mtDNA). Stavudine sodium reduces NLRP3 inflammasome activation and modulates […]

For research use only. We do not sell to patients. Acyclovir sodium CAS No. : 69657-51-8 Biological Activity：Acyclovir (Aciclovir) sodium is a potent, orally active antiviral agent. Acyclovir sodium has antiherpetic activity with IC50 values of 0.85 μM and 0.86 μM for HSV-1 and HSV-2, respectively. Acyclovir sodium induces cell cycle perturbation and apoptosis. Acyclovir […]

For research use only. We do not sell to patients. Lidocaine-d10 N-Oxide CAS No. : 851528-10-4 Biological Activity：Lidocaine-d10 N-Oxide is the deuterium labeled Lidocaine. Lidocaine (Lignocaine) inhibits sodium channels involving complex voltage and using dependence. Lidocaine decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and […]

For research use only. We do not sell to patients. Mocetinostat CAS No. : 726169-73-9 Biological Activity：Mocetinostat (MGCD0103) is a potent, orally active and isotype-selective HDAC (Class I/IV) inhibitor with IC50s of 0.15, 0.29, 1.66 and 0.59 μM for HDAC1, HDAC2, HDAC3 and HDAC11, respectively. Mocetinostat shows no inhibition on HDAC4, HDAC5, HDAC6, HDAC7, or […]

For research use only. We do not sell to patients. BRD4/CK2-IN-1 CAS No. : 2756851-99-5 Biological Activity：BRD4/CK2-IN-1 is the first highly effective and oral active dual-target inhibitor of BRD4/CK2 (bromodomain-containing protein 4/casein kinase 2), with IC50s of 180 nM and 230 nM for BRD4 and CK2, respectively. BRD4/CK2-IN-1 has strong anticancer activity without obvious toxicities. […]

For research use only. We do not sell to patients. CAM833 CAS No. : 2758364-02-0 Biological Activity：CAM833 is a potent orthosteric inhibitor of the interaction between BRCA2 and RAD51 with a Kd of 366 nM against the ChimRAD51 protein. CAM833 also inhibits RAD51 oligomerization. Research Area：Cancer Targets：RAD51|Apoptosis Related Small Molecules:Physalin A;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;BJE6-106;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II […]

For research use only. We do not sell to patients. Picropodophyllin CAS No. : 477-47-4 Biological Activity：Picropodophyllin (AXL1717) is a selective insulin-like growth factor-1 receptor (IGF-1R) inhibitor with an IC50 of 1 nM. Research Area：Cancer|Endocrinology Targets：IGF-1R|Apoptosis Related Screening Libraries:Covalent Screening Library Plus;Natural Product Library Plus;Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;Apoptosis […]

For research use only. We do not sell to patients. Kobe0065 CAS No. : 436133-68-5 Biological Activity：Kobe0065 is a novel and effective inhibitor of Ras-Raf interaction, competitively inhibiting the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki value of 46±13 μM. Research Area：Cancer Targets：Apoptosis|Ras Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;GPCR/G Protein Compound […]