Tag: Inducer|Inhibitor

For research use only. We do not sell to patients. VTP50469 fumarate CAS No. : 2169919-29-1 Biological Activity：VTP50469 fumarate is a potent, highly selective and orally active Menin-MLL interaction inhibitor with a Ki of 104 pM. VTP50469 fumarate has potently anti-leukemia activity[2]. Research Area：Cancer Targets：Epigenetic Reader Domain|Apoptosis Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Epigenetics […]

For research use only. We do not sell to patients. Larotrectinib-d7 Biological Activity：Larotrectinib-d7 (LOXO-101-d7) is the deuterium labeled Larotrectinib. Larotrectinib (LOXO-101) is an ATP-competitive oral, selective inhibitor of the tropomyosin-related kinase (TRK) family receptors, with low nanomolar 50% inhibitory concentrations against all three isoforms (TRKA, B, and C). Research Area：Cancer Targets：Trk Receptor|Apoptosis Related Small Molecules:Physalin […]

For research use only. We do not sell to patients. Actinonin CAS No. : 13434-13-4 Biological Activity：Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase. Actinonin is a potent reversible peptide deformylase (PDF) inhibitor with a Ki of 0.28 nM. Actinonin also inhibits MMP-1, […]

For research use only. We do not sell to patients. Baicalin CAS No. : 21967-41-9 Biological Activity：Baicalin, as a flavonoid glycoside, is an allosteric carnitine palmityl transferase 1 (CPT1) activator. Baicalin reduces the expression of NF-κB[2][3]. Research Area：Inflammation/Immunology|Cancer Targets：Autophagy|NF-κB|HIV Related Screening Libraries:Natural Product Library Plus;Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive […]

For research use only. We do not sell to patients. KPT-251 CAS No. : 1388841-50-6 Biological Activity：KPT-251 is an orally active chromosome region maintenance 1 protein (CRM1) inhibitor. KPT-251 induces cancer cell apoptosis and shows antileukemic activity[2]. Research Area：Cancer Targets：CRM1|Apoptosis Related Small Molecules:Physalin A;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;BJE6-106;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor 3;Xevinapant;Mangiferin;Cambinol;Antioxidant agent-5;Apoptosis inducer 9;Bafetinib;Cyclovirobuxine D;STAT3-IN-10;Rigosertib sodium […]

For research use only. We do not sell to patients. OTS514 hydrochloride CAS No. : 2319647-76-0 Biological Activity：OTS514 hydrochloride is a highly potent TOPK inhibitor, which inhibits TOPK kinase activity with a median inhibitory concentration (IC50) value of 2.6 nM. OTS514 hydrochloride strongly suppresses the growth of TOPK-positive cancer cells. OTS514 hydrochloride induces cell cycle […]

For research use only. We do not sell to patients. Aurora A inhibitor 2 CAS No. : 2412144-74-0 Biological Activity：Aurora A inhibitor 2 (Compound 16h) is a potent Aurora A kinase inhibitor with an IC50 of 21.94 nM. Aurora A inhibitor 2 induces caspase-dependent apoptosis in MDA-MB-231 cells. Research Area：Cancer Targets：Aurora Kinase|Apoptosis Related Small Molecules:Physalin […]

For research use only. We do not sell to patients. (S)-Verapamil-d6 hydrochloride CAS No. : 1329611-24-6 Biological Activity：(S)-Verapamil-d6 ((S)-(-)-Verapamil-d6) hydrochloride is the deuterium labeled (S)-Verapamil hydrochloride. (S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) inhibits leukotriene C4 (LTC4) and calcein transport by MRP1. (S)-Verapamil hydrochloride leads to the death of potentially resistant tumor cells[2]. Research Area：Cancer Targets：Calcium Channel|Leukotriene Receptor|Apoptosis […]

For research use only. We do not sell to patients. Irinotecan CAS No. : 97682-44-5 Biological Activity：Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex. Research Area：Cancer Targets：Topoisomerase|Autophagy Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;Cell Cycle/DNA […]

For research use only. We do not sell to patients. EGFR-IN-47 Biological Activity：EGFR-IN-47 is a potent and orally active EGFRL858R/T790M/C797S inhibitor with an IC50 of 0.01 µM. EGFR-IN-47 induces cell cycle attest and cell apoptosis. EGFR-IN-47 has the potential for the research of NSCLC. Research Area：Cancer Targets：EGFR|Apoptosis Related Small Molecules:Physalin A;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;NSC81111;BJE6-106;Dinaciclib;pp60 (v-SRC) Autophosphorylation […]