Tag: Inducer|Inhibitor

For research use only. We do not sell to patients. Luteolin CAS No. : 491-70-3 Biological Activity：Luteolin (Luteoline), a flavanoid compound, is a potent Nrf2 inhibitor. Luteolin has anti-inflammatory, anti-cancer properties, including the induction of apoptosis and cell cycle arrest, and the inhibition of metastasis and angiogenesis, in several cancer cell lines, including human non-small […]

For research use only. We do not sell to patients. Nilotinib-d6 CAS No. : 1268356-17-7 Biological Activity：Nilotinib D6 (AMN107 D6) is a deuterium labeled Nilotinib. Nilotinib is an orally available Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity. Research Area：Cancer Targets：Autophagy|Bcr-Abl Related Small Molecules:AT9283;Bafetinib;Pivanex;SNIPER(ABL)-039;Flumatinib mesylate;IHMT-TRK-284;SNIPER(ABL)-049;Olverembatinib;GNF-2;CT-721;SNIPER(ABL)-015;GNF-5;BCR-ABL-IN-4;SNIPER(ABL)-033;CHMFL-ABL-039;BCR-ABL-IN-6;c-ABL-IN-2;SNIPER(ABL)-058;ON 146040;HG-7-85-01;CHMFL-ABL/KIT-155;Radotinib-d6;BCR-ABL-IN-1;SIAIS178 Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  […]

For research use only. We do not sell to patients. Wedelolactone CAS No. : 524-12-9 Biological Activity：Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibits the IKK Complex. Wedelolactone also inhibits 5-lipoxygenase (5-Lox) with an IC50 of 2.5 μM. Wedelolactone induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt. Wedelolactone can […]

For research use only. We do not sell to patients. Afatinib-d4 Biological Activity：Afatinib-d4 (BIBW 2992-d4) is the deuterium labeled Afatinib. Afatinib (BIBW 2992) is an irreversible EGFR family inhibitor with IC50s of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively. Research Area：Cancer Targets：EGFR|Autophagy Related Small Molecules:NSC81111;pp60 (v-SRC) […]

For research use only. We do not sell to patients. Osthole CAS No. : 484-12-8 Biological Activity：Osthole (Osthol) is a natural antihistamine alternative. Osthole may be a potential inhibitor of histamine H1 receptor activity. Osthole also suppresses the secretion of HBV in cells. Research Area：Cancer|Infection|Endocrinology|Inflammation/Immunology|Cardiovascular Disease Targets：Parasite|Histamine Receptor|HBV|Apoptosis Related Screening Libraries:Natural Product Library Plus;Bioactive Compound […]

For research use only. We do not sell to patients. Lorlatinib-13C,d3 Biological Activity：Lorlatinib-13C,d3 (PF-06463922-13C,d3) is the 13C- and deuterium labeled Lorlatinib. Lorlatinib (PF-06463922) is a selective, orally active, brain-penetrant and ATP-competitive ROS1/ALK inhibitor. Lorlatinib has Kis of

For research use only. We do not sell to patients. Momelotinib-2,2,6,6-d4 CAS No. : 1619927-64-8 Biological Activity：Momelotinib-2,2,6,6-d4 (CYT387-2,2,6,6-d4) is the deuterium labeled Momelotinib (HY-10961). Momelotinib (CYT387) is an orally acitve and ATP-competitive JAK1/JAK2 inhibitor with IC50s of 11 nM and 18 nM, respectively[2]. Research Area：Cancer Targets：JAK|Autophagy|Apoptosis Related Small Molecules:Physalin A;Bomedemstat ditosylate;AZ-3;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;JAK3/BTK-IN-1;BJE6-106;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor […]

For research use only. We do not sell to patients. Otenaproxesul CAS No. : 1226895-20-0 Biological Activity：Otenaproxesul (ATB-346), an orally active non-steroidal anti-inflammatory drug (NSAID), inhibits cyclooxygenase-1 and 2 (COX-1 and 2). Otenaproxesul possesses antiinflammatory and antinociceptive activities[4]. Research Area：Inflammation/Immunology Targets：Apoptosis|COX Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;Apoptosis Compound […]

For research use only. We do not sell to patients. Regorafenib-d3 CAS No. : 1255386-16-3 Biological Activity：Regorafenib D3 (BAY 73-4506 D3) is a deuterium labeled Regorafenib. Regorafenib is a multi-targeted receptor tyrosine kinase inhibitor. Research Area：Cancer Targets：Autophagy|Raf|VEGFR|RET|PDGFR Related Small Molecules:(Z)-FeCP-oxindole;Avutometinib;VEGFR-2-IN-24;BMS-690514;PROTAC VEGFR-2 degrader-2;AZ 628;Henatinib;PI3K/VEGFR2-IN-1;Flumatinib mesylate;IHMT-TRK-284;RET-IN-18;PDGFRα/FLT3-ITD-IN-2;PP58;Hydroxytanshinone IIA;Chiauranib;Foretinib;ZM323881 hydrochloride;Zeteletinib;PTC299;ENMD-2076 Tartrate;Aflibercept;SU5408;MAZ51 Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  […]

For research use only. We do not sell to patients. Quercetin dihydrate CAS No. : 6151-25-3 Biological Activity：Quercetin dihydrate, a natural flavonoid, is a stimulator of recombinant SIRT1 and a PI3K inhibitor with IC50s of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively. Research Area：Inflammation/Immunology|Cancer Targets：Apoptosis|PI3K Related […]