Tag: Inducer|Inhibitor

For research use only. We do not sell to patients. Tubulysin F CAS No. : 368870-67-1 Biological Activity：Tubulysin F is a highly cytotoxic peptide isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis. Tubulysin displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the lower nanomolar range. […]

For research use only. We do not sell to patients. Imatinib Mesylate CAS No. : 220127-57-1 Biological Activity：Imatinib Mesylate (STI571 Mesylate) is a tyrosine kinases inhibitor that inhibits c-Kit, Bcr-Abl, and PDGFR (IC50=100 nM) tyrosine kinases. Research Area：Cancer Targets：Autophagy|Bcr-Abl|c-Kit|PDGFR Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;Kinase […]

For research use only. We do not sell to patients. Formononetin CAS No. : 485-72-3 Biological Activity：Formononetin is a potent FGFR2 inhibitor with an IC50 of ~4.31 μM. Formononetin potently inhibits angiogenesis and tumor growth. Research Area：Cancer|Cardiovascular Disease Targets：FGFR|Apoptosis Related Screening Libraries:Natural Product Library Plus;Bioactive Compound Library Plus;Apoptosis Compound Library;Kinase Inhibitor Library;Protein Tyrosine Kinase Compound […]

For research use only. We do not sell to patients. Thiamine monochloride-C13 hydrochloride CAS No. : 1257525-77-1 Biological Activity：Thiamine monochloride-C13 hydrochloride is the deuterium labeled Thiamine hydrochloride. Thiamine hydrochloride (Thiamine chloride hydrochloride) is an essential micronutrient needed as a cofactor for many central metabolic enzymes. Research Area：Neurological Disease Targets：HBV|Endogenous Metabolite|Apoptosis Related Small Molecules:D-α-Hydroxyglutaric acid disodium;Physalin […]

For research use only. We do not sell to patients. Oxaprozin potassium CAS No. : 174064-08-5 Biological Activity：Oxaprozin potassium is an orally active and potent COX inhibitor, with IC50 values of 2.2 μM for human platelet COX-1 and and 36 μM for IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin potassium also inhibits the activation of […]

For research use only. We do not sell to patients. Clofarabine CAS No. : 123318-82-1 Biological Activity：Clofarabine, a nucleoside analogue for research of cancer, is a potent inhibitor of ribonucleotide reductase (IC50=65 nM) by binding to the allosteric site on the regulatory subunit. Research Area：Metabolic Disease|Cancer Targets：Nucleoside Antimetabolite/Analog|Autophagy|Apoptosis Related Screening Libraries:Covalent Screening Library Plus;Natural Product-like […]

For research use only. We do not sell to patients. Apogossypolone CAS No. : 886578-07-0 Biological Activity：Apogossypolone (ApoG2) is an orally active Bcl-2 family proteins inhibitor with Ki values of 35, 25 and 660 nM for Bcl-2, Mcl-1 and Bcl-XL, respectively. Apogossypolone shows antitumor activities, induces cell apoptosis and autophagy[2]. Apogossypolone also has antifungal activity[3]. […]

For research use only. We do not sell to patients. AS-99 TFA Biological Activity：AS-99 TFA is a first-in-class, potent and selective ASH1L histone methyltransferase inhibitor (IC50= 0.79 µM, Kd= 0.89 µM) with anti-leukemic activity. AS-99 TFA blocks cell proliferation, induces apoptosis and differentiation, downregulates MLL fusion target genes, and reduces the leukemia burden in vivo. Research Area：Cancer Targets：Histone Methyltransferase|Apoptosis […]

For research use only. We do not sell to patients. Lonidamine CAS No. : 50264-69-2 Biological Activity：Lonidamine (AF-1890) is a hexokinase and mitochondrial pyruvate carrier inhibitor (Ki: 2.5 μM). Lonidamine also inhibits aerobic glycolysis in cancer cells. Lonidamine can be used in the research of mitochondrial metabolism and inflammation, such as pulmonary fibrosis[2][3]. Research Area：Cancer|Inflammation/Immunology […]

For research use only. We do not sell to patients. Rabeprazole CAS No. : 117976-89-3 Biological Activity：Rabeprazole (LY307640) is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H+/K+-ATPase. Rabeprazole induces apoptosis. Rabeprazole acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 μM. Rabeprazole can be used for the research […]