Tag: Inducer|Inhibitor

For research use only. We do not sell to patients. HDAC3/6-IN-2 CAS No. : 2417510-17-7 Biological Activity：HDAC3/6-IN-2 (compound 15) is a potent HDAC6 and HDAC3 inhibitor, with IC50 values of 0.368 and 0.635 μM, respectively. HDAC3/6-IN-2 shows antitumor activity, and induces cancer cell apoptosis. HDAC3/6-IN-2 decreases the levels of HDAC6 and HDAC3, associated with upregulation […]

For research use only. We do not sell to patients. NVP-2 CAS No. : 1263373-43-8 Biological Activity：NVP-2 is a potent and selective ATP-competitive cyclin dependent kinase 9 (CDK9) probe, inhibits CDK9/CycT activity with an IC50 of 0.514 nM. NVP-2 displays inhibitory effcts on CDK1/CycB, CDK2/CycA and CDK16/CycY kinases with IC50 values of 0.584 µM, 0.706 […]

For research use only. We do not sell to patients. Abacavir CAS No. : 136470-78-5 Biological Activity：Abacavir is an orally active and competitive nucleoside reverse transcriptase inhibitor. Abacavir can inhibits the replication of HIV. Abacavir shows anticancer activity in prostate cancer cell lines. Abacavir can trespass the blood-brain-barrier and suppresses telomerase activity[2][3]. Research Area：Cancer|Infection Targets：Telomerase|HIV|Apoptosis|Reverse […]

For research use only. We do not sell to patients. CDK9-IN-18 CAS No. : 1804127-83-0 Biological Activity：CDK9-IN-18 is a potent CDK9 inhibitor. CDK9-IN-18 blocks the phosphorylation function of kinase CDK9. CDK9-IN-18 exhibits both good anticancer activity and low cellular activity. CDK9-IN-18 induces apoptosis. Research Area：Cancer Targets：CDK|Apoptosis Related Small Molecules:Physalin A;Bomedemstat ditosylate;DB0614;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;BJE6-106;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor […]

For research use only. We do not sell to patients. SBE13 CAS No. : 775294-82-1 Biological Activity：SBE13 is a potent and selective Plk1 inhibitor, with an IC50 of 200 pM; SBE13 poorly inhibits Plk2 (IC50>66 μM) or Plk3 (IC50=875 nM). Research Area：Cancer Targets：Autophagy|Polo-like Kinase (PLK) Related Small Molecules:TAK-960;Rigosertib sodium;Centrinone;HMN-176;(1E)-CFI-400437 dihydrochloride;Poloxin;PLK1-IN-2;PLK1-IN-4;MLN0905;TC-S 7005;PLK4-IN-3;SBE13 Hydrochloride;CFI-400437;Plogosertib;Volasertib;3MB-PP1;Wortmannin;PLK1/BRD4-IN-1;Poloxime;Poloppin;Cyclapolin 9;ON1231320;BI 2536 Trending products：Recombinant Proteins  […]

For research use only. We do not sell to patients. Venetoclax CAS No. : 1257044-40-8 Biological Activity：Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable Bcl-2 inhibitor with a Ki of less than 0.01 nM. Venetoclax induces autophagy[2][3]. Research Area：Cancer Targets：Autophagy|Bcl-2 Family Related Screening Libraries:Covalent Screening Library Plus;Drug Repurposing Compound Library Plus;FDA-Approved Drug […]

For research use only. We do not sell to patients. PARP1/BRD4-IN-2 Biological Activity：PARP1/BRD4-IN-2 is a potent and selective PARP1 and BRD4 inhibitor with IC50 values of 197 nM and 238 nM, respectively. PARP1/BRD4-IN-2 inhibits DNA damage repair, arrests G0/G1 transition and induces apoptosis. PARP1/BRD4-IN-2 has anti-tumor activity in MDA-MB-468 xenograft mouse model. PARP1/BRD4-IN-2 can be […]

For research use only. We do not sell to patients. 2-Deoxy-D-glucose CAS No. : 154-17-6 Biological Activity：2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase. Research Area：Cancer Targets：HSV|Hexokinase|Apoptosis Related Screening Libraries:Natural Product Library Plus;Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library […]

For research use only. We do not sell to patients. Seribantumab CAS No. : 1334296-12-6 Biological Activity：Seribantumab (MM 121) is a fully human IgG2 monoclonal antibody that targets HER3. Seribantumab blocks the activation of epidermal growth factor receptor (ErbB) family members and its downstream signal. Seribantumab inhibits neuregulin 1 (NRG1) fusion-dependent tumorigenesis in vitro and […]

For research use only. We do not sell to patients. Gefitinib-d3 CAS No. : 1173976-40-3 Biological Activity：Gefitinib-d3 (ZD1839-d3) is the deuterium labeled Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that […]