Tag: Inducer|Inhibitor

For research use only. We do not sell to patients. MK-2206 dihydrochloride CAS No. : 1032350-13-2 Biological Activity：MK-2206 dihydrochloride (MK-2206 (2HCl)) is an orally active allosteric AKT inhibitor with IC50s of 5 nM, 12 nM, and 65 nM for AKT1, AKT2, and AKT3, respectively. MK-2206 dihydrochloride induces autophagy[3]. Research Area：Cancer Targets：Akt|Autophagy|Apoptosis Related Screening Libraries:Drug Repurposing […]

For research use only. We do not sell to patients. FLT3/TrKA-IN-1 Biological Activity：FLT3/TrKA-IN-1 is a potent FLT3/TrKA dual kinase inhibitor with the IC50s of 43.8 nM, 97.2 nM, 92.5 nM and 23.6 nM for FLT3, FLT3-ITD, FLT3-TKD and TrKA, respectively. FLT3/TrKA-IN-1 induces cell cycle arrest at the G0/G1 phase as well as apoptosis and shows […]

For research use only. We do not sell to patients. Metronidazole hydrochloride CAS No. : 69198-10-3 Biological Activity：Metronidazole hydrochloride (SC 326421) is an orally active nitroimidazole antibiotic, can be used to research anaerobic infections. Metronidazole hydrochloride can cross blood brain barrier and results inflammation and skeletal muscle contraction under long-term application[2][3][4]. Research Area：Infection|Inflammation/Immunology Targets：Parasite|Bacterial|Antibiotic|Apoptosis Related […]

For research use only. We do not sell to patients. Tubastatin A Hydrochloride CAS No. : 1310693-92-5 Biological Activity：Tubastatin A Hydrochloride (Tubastatin A HCl) is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in a cell-free assay, and is selective (1000-fold more) against all other isozymes except HDAC8 (57-fold more). Tubastatin A Hydrochloride also inhibits HDAC10 […]

For research use only. We do not sell to patients. Cytarabine hydrochloride CAS No. : 69-74-9 Biological Activity：Cytarabine hydrochloride, a nucleoside analog, causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC50 of 16 nM. Cytarabine hydrochloride has antiviral effects against HSV. Research Area：Cancer|Infection Targets：HSV|Nucleoside Antimetabolite/Analog|Autophagy|DNA/RNA Synthesis Related […]

For research use only. We do not sell to patients. Rilmenidine hemifumarate CAS No. : 207572-68-7 Biological Activity：Rilmenidine hemifumarate, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine hemifumarate is an alpha 2-adrenoceptor agonist. Rilmenidine hemifumarate induces autophagy. Rilmenidine hemifumarate acts both centrally by reducing sympathetic overactivity and in the […]

For research use only. We do not sell to patients. Vincristine-d6 sulfate Biological Activity：Vincristine-d6 (Leurocristine-d6) sulfate is the deuterium labeled Vincristine sulfate. Vincristine sulfate is an antitumor vinca alkaloid which inhibits microtubule formation in mitotic spindle, resulting in an arrest of dividing cells at the metaphase stage. It binds to microtubule with a Ki of […]

For research use only. We do not sell to patients. Z-LLNle-CHO CAS No. : 133407-83-7 Biological Activity：Z-LLNle-CHO (Z-Leu-Leu-Nle-CHO) is a γ-secretase inhibitor I. Z-LLNle-CHO induces caspase and ROS-dependent apoptosis by blocking the Akt-mediated pro-survival pathway. Z-LLNle-CHO can be used in cancer research, such as breast cancer and leukaemia[2]. Research Area：Cancer Targets：γ-secretase|Proteasome|Apoptosis Related Small Molecules:Physalin A;Bomedemstat […]

For research use only. We do not sell to patients. Omeprazole-d3-1 CAS No. : 934293-92-2 Biological Activity：Omeprazole-d3-1 (H 16868-d3-1) is the deuterium labeled Omeprazole. Omeprazole (H 16868), a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM. […]

For research use only. We do not sell to patients. PF-3758309 hydrochloride CAS No. : 1279034-84-2 Biological Activity：PF-3758309 (PF-03758309) hydrochloride is a potent, orally available, and reversible ATP-competitive inhibitor of PAK4 (Kd= 2.7 nM; Ki=18.7 nM). PF-3758309 hydrochloride has the expected cellular functions of a PAK4 inhibitor: inhibition of anchorage-independent growth, induction of apoptosis, cytoskeletal […]