Tag: Inducer|Inhibitor

For research use only. We do not sell to patients. Topotecan Hydrochloride CAS No. : 119413-54-6 Biological Activity：Topotecan Hydrochloride (SKF 104864A Hydrochloride) is a Topoisomerase I inhibitor with potent antineoplastic activities. Research Area：Cancer Targets：Topoisomerase|Autophagy|Apoptosis Related Screening Libraries:Natural Product Library Plus;Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;Apoptosis Compound Library;Cell […]

For research use only. We do not sell to patients. Regorafenib CAS No. : 755037-03-7 Biological Activity：Regorafenib (BAY 73-4506) is an orally active and potent multi-targeted receptor tyrosine kinase inhibitor, with IC50 values of 13/4.2/46, 22, 7, 1.5 and 2.5 nM for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1, respectively. Regorafenib shows very robust antitumor and […]

For research use only. We do not sell to patients. Afatinib CAS No. : 850140-72-6 Biological Activity：Afatinib (BIBW 2992) is an orally active, potent and irreversible dual specificity inhibitor of ErbB family (EGFR and HER2), with IC50 values of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively. […]

For research use only. We do not sell to patients. Aliskiren fumarate CAS No. : 1196835-68-3 Biological Activity：Aliskiren fumarate is an orally active, highly potent and selective renin inhibitor, with IC50 of 1.5 nM. Aliskiren fumarate can be used for the research of hypertension, cardiovascular diseases and cancer cachexia[2][3]. Research Area：Cancer|Cardiovascular Disease Targets：Autophagy|Renin Related Small […]

For research use only. We do not sell to patients. Trametinib-13C6 Biological Activity：Trametinib-13C6 is the 13C-labeled Trametinib. Trametinib (GSK1120212; JTP-74057) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC50s of about 2 nM. Trametinib activates autophagy and induces apoptosis[2]. Research Area：Cancer Targets：MEK|Autophagy|Apoptosis Related Small Molecules:Physalin A;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Avutometinib;Lobetyolin;BJE6-106;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor […]

For research use only. We do not sell to patients. CHIR-124 CAS No. : 405168-58-3 Biological Activity：CHIR-124 is a potent and selective Chk1 inhibitor with IC50 of 0.3 nM, and also potently targets PDGFR and FLT3 with IC50s of 6.6 nM and 5.8 nM. Research Area：Cancer Targets：FLT3|Apoptosis|PDGFR|Checkpoint Kinase (Chk) Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis […]

For research use only. We do not sell to patients. HDAC-IN-9 Biological Activity：HDAC-IN-9 is a potent and selective tubulin and HDAC dual inhibitor. HDAC-IN-9 inhibits the invasion and migration of A549 cells. HDAC-IN-9 shows potent antitumor and antiangiogenic effect in vitro and in vivo. Research Area：Cancer Targets：Microtubule/Tubulin|HDAC|Apoptosis Related Small Molecules:Physalin A;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;Tirbanibulin dihydrochloride;BJE6-106;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase […]

For research use only. We do not sell to patients. HDAC-IN-42 CAS No. : 2454024-18-9 Biological Activity：HDAC-IN-42 (compound 14f) is a potent and selective HDAC inhibitor with IC50 values of 0.19 and 4.98 µM for HDAC1 and HDAC6, respectively. HDAC-IN-42 shows anticancer and anti-proliferative activity. HDAC-IN-42 induces apoptosis and cell cycle arrest at G2/M phase. […]

For research use only. We do not sell to patients. mTOR inhibitor-1 CAS No. : 468747-17-3 Biological Activity：mTOR inhibitor-1 is a novel mTOR pathway inhibitor which can suppress cells proliferation and inducing autophagy. Research Area：Cancer Targets：Autophagy|mTOR Related Screening Libraries:Bioactive Compound Library Plus;Kinase Inhibitor Library;PI3K/Akt/mTOR Compound Library;Stem Cell Signaling Compound Library;Anti-Cancer Compound Library;Autophagy Compound Library;Anti-Aging Compound […]

For research use only. We do not sell to patients. Omeprazole-13CD3 CAS No. : 1261395-28-1 Biological Activity：Omeprazole-13CD3 (H 16868-13CD3) is a 13C-labeled and deuterium labeled Omeprazole. Omeprazole (H 16868), a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Ki of 2 to […]