Tag: Inducer|Inhibitor

For research use only. We do not sell to patients. Floxuridine CAS No. : 50-91-9 Biological Activity：Floxuridine (5-Fluorouracil 2′-deoxyriboside) is a pyrimidine analog and known as an oncology antimetabolite. Floxuridine inhibits Poly(ADP-Ribose) polymerase and induces DNA damage by activating the ATM and ATR checkpoint signaling pathways in vitro. Floxuridine is a extreamly potent inhibitor for S. aureus infection and […]

For research use only. We do not sell to patients. NVP-TAE 226 CAS No. : 761437-28-9 Biological Activity：NVP-TAE 226 (TAE226) is a potent and ATP-competitive dual FAK and IGF-1R inhibitor with IC50s of 5.5 nM and 140 nM, respectively. NVP-TAE 226 (TAE226) also effectively inhibits Pyk2 and insulin receptor (InsR) with IC50s of 3.5 nM […]

For research use only. We do not sell to patients. Camptothecin-d5 CAS No. : 1329616-37-6 Biological Activity：Camptothecin-d5 (Campathecin-d5) is the deuterium labeled Camptothecin. Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC50 of 679 nM. Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian […]

For research use only. We do not sell to patients. RMS3 CAS No. : 2497686-66-3 Biological Activity：RMS3, a tetrandrine analogue, is a potent P-glycoprotein (P-gp) inhibitor. RMS3 has markedly antiproliferative and cytotoxic effects on cancer cells. RMS3 causes PARP cleavage, a marker for cells undergoing apoptosis. RMS3 has strong anticancer property. Research Area：Cancer Targets：P-glycoprotein|Apoptosis Related […]

For research use only. We do not sell to patients. TP-472 CAS No. : 2079895-62-6 Biological Activity：TP-472 is a selective BRD9/7 inhibitor, with Kds of 33 nM and 340 nM for BRD9 and BRD7, respectively. TP-472 exhibits >30-fold selectivity for BRD9 over other bromodomain family members except BRD7[2]. TP-472 induces apoptosis of melanoma cells[3]. Research […]

For research use only. We do not sell to patients. Abacavir-d4 CAS No. : 1260619-56-4 Biological Activity：Abacavir-d4 is the deuterium labeled Abacavir. Abacavir is a potent nucleoside analog reverse-transcriptase inhibitor (NRTI)[2]. Research Area：Infection Targets：HIV|Apoptosis|Reverse Transcriptase Related Small Molecules:Physalin A;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;BJE6-106;Dinaciclib;HIV-1 TAT (48-60);Ecteinascidin 770;MDM2-p53-IN-15;Seletracetam lithium;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor 3;HIV-IN-2;Xevinapant;Mangiferin;Cambinol;Antioxidant agent-5;Apoptosis inducer 9 Trending products：Recombinant Proteins  |  […]

For research use only. We do not sell to patients. Capmatinib dihydrochloride hydrate CAS No. : 1865733-40-9 Biological Activity：Capmatinib (INC280; INCB28060) dihydrochloride hydrate is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor (IC50=0.13 nM). Capmatinib dihydrochloride hydrate can inhibit phosphorylation of c-MET as well as c-MET pathway downstream effectors such as ERK1/2, […]

For research use only. We do not sell to patients. Lamotrigine CAS No. : 84057-84-1 Biological Activity：Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy, focal seizure, et al[2]. Research […]

For research use only. We do not sell to patients. VEGFR-2-IN-28 CAS No. : 2447597-39-7 Biological Activity：VEGFR-2-IN-28 (compound 12c) is a potent VEGFR-2 inhibitor with IC50 value of 0.83 µM. VEGFR-2-IN-28 induces apoptosis and has anticancer activity. Research Area：Cancer Targets：VEGFR|Apoptosis Related Small Molecules:Physalin A;Bomedemstat ditosylate;(Z)-FeCP-oxindole;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;BJE6-106;Dinaciclib;VEGFR-2-IN-24;Ecteinascidin 770;MDM2-p53-IN-15;BMS-690514;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor 3;Xevinapant;Mangiferin;Cambinol;Antioxidant agent-5 Trending products：Recombinant Proteins  |  […]

For research use only. We do not sell to patients. Paeonol CAS No. : 552-41-0 Biological Activity：Paeonol is an active extraction from the root of Paeonia suffruticosa, Paeonol inhibits MAO-A and MAO-B with IC50 of 54.6 μM and 42.5 μM, respectively. Research Area：Neurological Disease|Cancer Targets：Autophagy|Monoamine Oxidase Related Screening Libraries:Natural Product Library Plus;Drug Repurposing Compound Library […]