Tag: Inducer|Inhibitor

For research use only. We do not sell to patients. PF-3758309 CAS No. : 898044-15-0 Biological Activity：PF-3758309 (PF-03758309) is a potent, orally available, and reversible ATP-competitive inhibitor of PAK4 (Kd= 2.7 nM; Ki=18.7 nM). PF-3758309 has the expected cellular functions of a PAK4 inhibitor: inhibition of anchorage-independent growth, induction of apoptosis, cytoskeletal remodeling, and inhibition […]

For research use only. We do not sell to patients. Rapamycin CAS No. : 53123-88-9 Biological Activity：Rapamycin (Sirolimus; AY 22989) is a potent and specific mTOR inhibitor with an IC50 of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator, an […]

For research use only. We do not sell to patients. S-Trityl-L-cysteine CAS No. : 2799-07-7 Biological Activity：S-Trityl-L-cysteine (NSC 83265) is a selective and allosteric kinesin Eg5 inhibitor with an IC50 of 1 μM for the inhibition of basal ATPase activity and 140 nM for the microtubule-activated ATPase activity. S-Trityl-L-cysteine has antitumor activities[2]. Research Area：Cancer Targets：Kinesin|Apoptosis […]

For research use only. We do not sell to patients. 4-Epianhydrotetracycline hydrochloride CAS No. : 4465-65-0 Biological Activity：4-Epianhydrotetracycline hydrochloride is a major intermediate product of Tetracycline (HY-A0107). 4-Epianhydrotetracycline hydrochloride shows lethal effects and induces cell apoptosis of zebrafish embryos. 4-Epianhydrotetracycline hydrochloride inhibits Shewanella, E. coli and P. aeruginosa with MIC values of 2, 1 and […]

For research use only. We do not sell to patients. RMS5 CAS No. : 2497686-68-5 Biological Activity：RMS5, a tetrandrine analogue, is a potent P-glycoprotein (P-gp) inhibitor. RMS5 has markedly antiproliferative and cytotoxic effects on cancer cells. RMS5 slightly diminishes the expression of the anti-apoptotic Bcl-2 family proteins Bcl-XL and Mcl-1. RMS3 causes PARP cleavage, a […]

For research use only. We do not sell to patients. Ralimetinib dimesylate CAS No. : 862507-23-1 Biological Activity：Ralimetinib dimesylate (LY2228820 dimesylate) is a selective, ATP-competitive inhibitor of p38 MAPK α/β with IC50s of 5.3 and 3.2 nM, respectively. Ralimetinib (LY2228820) selectively inhibits phosphorylation of MK2 (Thr334), with no effect on phosphorylation of p38a MAPK, JNK, […]

For research use only. We do not sell to patients. Nafamostat mesylate CAS No. : 82956-11-4 Biological Activity：Nafamostat mesylate, a synthetic serine protease inhibitor, is an anticoagulant. Nafamostat mesylate supresses T cell auto-reactivity by decreasing granzyme activity and CTL cytolysis. Nafamostat mesylate blocks activation of SARS-CoV-2.[2][3][4]. Research Area：Cardiovascular Disease|Cancer Targets：Ser/Thr Protease|Apoptosis|SARS-CoV Related Screening Libraries:Drug Repurposing […]

For research use only. We do not sell to patients. PI3K/Akt/mTOR-IN-2 CAS No. : 2757804-89-8 Biological Activity：PI3K/Akt/mTOR-IN-2 is a PI3K/AKT/mTOR pathway inhibitor. PI3K/Akt/mTOR-IN-2 possess anti-cancer effects and selectivity against MDA-MB-231 cells with IC50 value of 2.29 μM. PI3K/Akt/mTOR-IN-2 can induce cancer cell cycle arrest and apoptosis. Research Area：Cancer Targets：Akt|mTOR|Apoptosis|PI3K Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis […]

For research use only. We do not sell to patients. Autophagy-IN-2 CAS No. : 2755454-90-9 Biological Activity：Autophagy-IN-2 (Compound 7h) is an autophagic flux inhibitor. Autophagy-IN-2 induces cancer cell apoptosis and can be used for triple-negative breast cancer research. Research Area：Cancer Targets：Autophagy|Apoptosis Related Small Molecules:Physalin A;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;BJE6-106;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor 3;Xevinapant;Mangiferin;Cambinol;Antioxidant agent-5;Apoptosis inducer 9;Bafetinib;Cyclovirobuxine D;STAT3-IN-10;Rigosertib […]

For research use only. We do not sell to patients. CCCP CAS No. : 555-60-2 Biological Activity：CCCP is an oxidative phosphorylation (OXPHOS) uncoupler. CCCP induces activation of PINK1 leading to Parkin Ser65 phosphorylation. Research Area：Cancer|Inflammation/Immunology Targets：IFNAR|STING|Bacterial|Apoptosis|Mitochondrial Metabolism Related Screening Libraries:Bioactive Compound Library Plus;Anti-Infection Compound Library;Apoptosis Compound Library;Immunology/Inflammation Compound Library;Kinase Inhibitor Library;Metabolism/Protease Compound Library;Stem Cell Signaling […]