Tag: Inducer|Inhibitor

For research use only. We do not sell to patients. E3330 CAS No. : 136164-66-4 Biological Activity：E3330 (APX-3330) is a direct, orally active and selective inhibitor of Ape-1 (apurinic/apyrimidinic endonuclease 1)/Ref-1 (redox factor-1) redox. E3330 is able to impair tumor growth and blocks the activity of NF-κB, AP-1, and HIF-1α in pancreatic cancer. E3330 shows […]

For research use only. We do not sell to patients. ONO-4059 analog CAS No. : 1351635-67-0 Biological Activity：ONO-4059 analog is the analog of ONO-4059, ONO-4059 is a highly potent and selective Btk inhibitor. IC50 value: sub-nM range [2] Target: Btk in vitro: ONO-4059 is a selective, once-daily, oral inhibitor of BTK, which has been shown […]

For research use only. We do not sell to patients. Andrographolide CAS No. : 5508-58-7 Biological Activity：Andrographolide is a NF-κB inhibitor, which inhibits NF-κB activation through covalent modification of a cysteine residue on p50 in endothelial cells without affecting IκBα degradation or p50/p65 nuclear translocation. Andrographolide has antiviral effects. Research Area：Cancer|Infection|Inflammation/Immunology Targets：Parasite|Autophagy|Influenza Virus|NF-κB|SARS-CoV Related Screening […]

For research use only. We do not sell to patients. Mangostin-d3 CAS No. : 1185047-73-7 Biological Activity：alpha-Mangostin-d3 (α-Mangostin-d3) is the deuterium labeled alpha-Mangostin. alpha-Mangostin (α-Mangostin) is a dietary xanthone with broad biological activities, such as antioxidant, anti-allergic, antiviral, antibacterial, anti-inflammatory and anticancer effects. It is an inhibitor of mutant IDH1 (IDH1-R132H) with a Ki of […]

For research use only. We do not sell to patients. VER-50589 CAS No. : 747413-08-7 Biological Activity：VER-50589 is a Hsp90 inhibitor, with an IC50 of 21 nM and a Kd of 4.5 nM. Research Area：Cancer Targets：HSP|Apoptosis Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Cell Cycle/DNA Damage Compound Library;Metabolism/Protease Compound Library;Anti-Cancer Compound Library;Anti-Aging Compound Library;Endoplasmic Reticulum […]

For research use only. We do not sell to patients. Citalopram hydrobromide CAS No. : 59729-32-7 Biological Activity：Citalopram hydrobromide is a selective serotonin reuptake inhibitor (SSRI). Citalopram hydrobromide inhibits 5-HT uptake into synaptosomes with an IC50 of 1.8 nM. Citalopram hydrobromideinhibits the 5-HT uptake in rabbit blood platelets with an IC50 of 14 nM. Antidepressant […]

For research use only. We do not sell to patients. Tigecycline CAS No. : 220620-09-7 Biological Activity：Tigecycline (GAR-936) is a broad-spectrum glycylcycline antibiotic. The mean inhibitory concentration (MIC) of Tigecycline for E. coli (MG1655 strain) is approximately 125 ng/mL. MIC50 and MIC90 are 1 and 2 mg/L for Acinetobacter baumannii (A. baumannii), respectively[2]. Research Area：Infection|Cancer […]

For research use only. We do not sell to patients. LY294002 CAS No. : 154447-36-6 Biological Activity：LY294002 is a broad-spectrum inhibitor of PI3K with IC50s of 0.5, 0.57, and 0.97 μM for PI3Kα, PI3Kδ and PI3Kβ, respectively. LY294002 also inhibits CK2 with an IC50 of 98 nM[2]. LY294002 is a competitive DNA-PK inhibitor that binds […]

For research use only. We do not sell to patients. Erdafitinib CAS No. : 1346242-81-6 Biological Activity：Erdafitinib (JNJ-42756493) is a potent and orally available FGFR family inhibitor; inhibits FGFR1/2/3/4 with IC50s of 1.2, 2.5, 3.0 and 5.7 nM, respectively. Research Area：Cancer Targets：FGFR|Apoptosis Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive […]

For research use only. We do not sell to patients. Tolcapone-d4 CAS No. : 1246816-93-2 Biological Activity：Tolcapone-d4 (Ro 40-7592-d4) is the deuterium labeled Tolcapone. Tolcapone (Ro 40-7592) is a selective, orally active and powerful mixed (peripheral and central) COMT inhibitor with an IC50 of 773 nM in the liver. Tolcapone is also a potent inhibitor of […]