Tag: Inducer|Inhibitor

For research use only. We do not sell to patients. Alvespimycin hydrochloride CAS No. : 467214-21-7 Biological Activity：Alvespimycin hydrochloride (17-DMAG hydrochloride; KOS-1022; BMS 826476) is a potent inhibitor of Hsp90, binding to Hsp90 with EC50 of 62±29 nM. Research Area：Cancer Targets：HSP|Apoptosis Related Screening Libraries:Covalent Screening Library Plus;Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound […]

For research use only. We do not sell to patients. Regorafenib Hydrochloride CAS No. : 835621-07-3 Biological Activity：Regorafenib Hydrochloride (BAY 73-4506 hydrochloride) is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1 with IC50s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM, respectively. Research Area：Cancer Targets：Autophagy|Raf|VEGFR|RET|PDGFR Related Screening Libraries:Covalent Screening Library Plus;Drug Repurposing Compound […]

For research use only. We do not sell to patients. Idarubicin hydrochloride CAS No. : 57852-57-0 Biological Activity：Idarubicin hydrochloride is an anthracycline antileukemic drug. It inhibits the topoisomerase II interfering with the replication of DNA and RNA transcription. Idarubicin hydrochloride inhibits the growth of bacteria and yeasts. Research Area：Cancer|Infection Targets：Topoisomerase|Fungal|Autophagy|DNA/RNA Synthesis|Bacterial|Antibiotic|c-Myc Related Screening Libraries:Covalent Screening […]

For research use only. We do not sell to patients. MNK1/2-IN-6 Biological Activity：MNK1/2-IN-6 is a potent and selective MNK1/2 inhibitor with IC50s of 2.3 nM and 3.4 nM for MNK1 and MNK2, respectively. MNK1/2-IN-6 induces apoptosis in a concentration-dependent manner. Research Area：Cancer Targets：MNK|Apoptosis Related Small Molecules:Physalin A;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;BJE6-106;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor 3;Xevinapant;Mangiferin;Cambinol;Antioxidant agent-5;Apoptosis inducer […]

For research use only. We do not sell to patients. IACS-010759 CAS No. : 1570496-34-2 Biological Activity：IACS-010759 is an orally active, potent mitochondrial complex I of oxidative phosphorylation (OXPHOS) inhibitor. IACS-010759 inhibits proliferation and induces apoptosis in models of brain cancer and acute myeloid leukemia (AML) reliant on OXPHOS. IACS-010759 has the potential for relapsed/refractory […]

For research use only. We do not sell to patients. ULK1-IN-2 CAS No. : 2497409-01-3 Biological Activity：ULK1-IN-2 (compound 3s) is a potent ULK1 inhibitor. ULK1-IN-2 shows highest cytotoxic effect against cancer cell lines, with IC50 of 1.94 μM in A549. ULK1-IN-2 can induce apoptosis and simultaneously block autophagy, and can be used to study NSCLC […]

For research use only. We do not sell to patients. FLDP-5 CAS No. : 950665-12-0 Biological Activity：FLDP-5 is a blood-brain barrier (BBB) penetrant curcuminoid analogues. FLDP-5 can induce production of ROS (Reactive Oxygen Species), DNA damage and cell cycle S phase arrest. FLDP-5 exhibits highly potent tumour-suppressive effects with anti-proliferative and anti-migratory activities on LN-18 […]

For research use only. We do not sell to patients. Evogliptin tartrate CAS No. : 1222102-51-3 Biological Activity：Evogliptin (DA-1229) tartrate is an orally active DPP4 inhibitor with significant and sustained hypoglycaemic effects in mouse models. Evogliptin tartrate also inhibits the production of inflammatory and fibrotic signals in hepatocytes by inducing autophagy. Evogliptin tartrate can be […]

For research use only. We do not sell to patients. Topotecan-d5 CAS No. : 1133355-98-2 Biological Activity：Topotecan-d5 is the deuterium labeled Topotecan. Topotecan (SKF 104864A; NSC 609669) is a Topoisomerase I inhibitor. The IC50 values of Topotecan at 24 h are 2.73±0.25 μM of U251 cells, 2.95±0.23 μM of U87 cells, 5.46±0.41 μM of GSCs-U251 […]

For research use only. We do not sell to patients. Griseofulvin-13C,d3 CAS No. : 1329612-29-4 Biological Activity：Griseofulvin-13C,d3 is the 13C- and deuterium labeled Griseofulvin. Research Area：Infection|Cancer Targets：Fungal|Antibiotic|Endogenous Metabolite|Apoptosis Related Small Molecules:D-α-Hydroxyglutaric acid disodium;Antifungal agent 20;Physalin A;Nicotinamide N-oxide;3-Hydroxyglutaric acid-d5;DPPC-d62;SDMA-d6;Bomedemstat ditosylate;2-Mercaptobenzothiazole;Sandramycin;N-Acetyl-L-glutamic acid-d5;(3R,5S)-3-Hydroxy Cotinine-d3;Enpp/Carbonic anhydrase-IN-1;Biliverdin hydrochloride;GK563;Calpeptin;Oritavancin;Lobetyolin;Monascorubrin;Azlocillin sodium salt;D-Glucose-13C,d1-3;2,3-Diaminopropionic acid hydrochloride Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  […]