Tag: Inducer|Inhibitor

For research use only. We do not sell to patients. SR-4835 CAS No. : 2387704-62-1 Biological Activity：SR-4835 is a potent, highly selective and ATP competitive dual inhibitor of CDK12/CDK13 (CDK12: IC50=99 nM, Kd=98 nM; CDK13: Kd=4.9 nM). SR-4835 acts in synergy with DNA-damaging chemotherapy and PARP inhibitors and provokes triple-negative breast cancer (TNBC) cell death. […]

For research use only. We do not sell to patients. Gemcitabine CAS No. : 95058-81-4 Biological Activity：Gemcitabine (LY 188011) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine inhibits DNA synthesis and repair, resulting in autophagyand apoptosis[2]. Research Area：Cancer Targets：Nucleoside Antimetabolite/Analog|Autophagy|DNA/RNA Synthesis|Apoptosis Related Screening Libraries:Covalent Screening Library Plus;Natural Product-like Compound Library;Drug Repurposing Compound […]

For research use only. We do not sell to patients. PAA5 Biological Activity：PAA5 is a methide carbon-centered polynuclear Au(I) cluster. PAA5 can release Au(I) causing Pro-oxidant response and accelerated ferroptosis. PAA5 increases the expression of pH2AX in a time-dependent manner. PAA5 has anticancer activity. Research Area：Cancer Targets：Ferroptosis|Reactive Oxygen Species|Endogenous Metabolite Related Small Molecules:D-α-Hydroxyglutaric acid disodium;Nicotinamide […]

For research use only. We do not sell to patients. ICG-001 CAS No. : 780757-88-2 Biological Activity：ICG-001 is an inhibitor of β-catenin/TCF mediated transcription. ICG-001 works by specifically binding to cyclic AMP response element-binding protein with an IC50 of 3 μM. ICG-001 selectively blocks the β-catenin/CBP interaction without interfering with the β-catenin/p300 interaction. Research Area：Cancer […]

For research use only. We do not sell to patients. Dauricine CAS No. : 524-17-4 Biological Activity：Dauricine, a bisbenzylisoquinoline alkaloid in Menispermum dauricum, possesses anti-inflammatory activity. Dauricine inhibits cell proliferation and invasion, and induces apoptosis by suppressing NF-κB activation in a dose- and time-dependent manner in colon cancer. Research Area：Cancer|Inflammation/Immunology Targets：NF-κB|Apoptosis Related Screening Libraries:Natural Product […]

For research use only. We do not sell to patients. Daunorubicin CAS No. : 20830-81-3 Biological Activity：Daunorubicin (Daunomycin) is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin inhibits DNA and RNA synthesis. Daunorubicin is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin is also an anthracycline antibiotic. Daunorubicin can […]

For research use only. We do not sell to patients. BTK-IN-15 Biological Activity：BTK-IN-15 is a potent Bruton’s tyrosine kinase (BTK) inhibitor with high oral absorption. BTK-IN-15 inhibits BTK with an IC50 value of 0.7 nM. BTK-IN-15 displays excellent kinase selectivity, antitumor activity, and induces apoptosis. Research Area：Cancer Targets：Pyroptosis|Btk Related Small Molecules:JAK3/BTK-IN-1;Elsubrutinib;ARQ 531;PF-06250112;PCI 29732;CHMFL-EGFR-202;Ac-FEID-CMK TFA;Avitinib;RN486;GDC-0834 Racemate;Spebrutinib […]

For research use only. We do not sell to patients. Corilagin CAS No. : 23094-69-1 Biological Activity：Corilagin, a gallotannin, has anti-tumor, anti-inflammatory and hepatoprotective activities. Corilagin inhibits activity of reverse transcriptase of RNA tumor viruses. Corilagin also inhibits the growth of Staphylococcus aureus with a MIC of 25 μg/mL. Corilagin shows anti-tumor activity on hepatocellular […]

For research use only. We do not sell to patients. Benralizumab CAS No. : 1044511-01-4 Biological Activity：Benralizumab (MEDI-563) is an interleukin-5 receptor α (IL-5Rα)-directed cytolytic monoclonal antibody that induces direct, rapid and nearly complete depletion of eosinophils via enhanced antibody-dependent cell-mediated cytotoxicity. Benralizumab can be used for severe eosinophilic asthma. Research Area：Inflammation/Immunology|Cancer Targets：Interleukin Related|Apoptosis Related […]

For research use only. We do not sell to patients. Calicheamicin CAS No. : 108212-75-5 Biological Activity：Calicheamicin, an antitumor antibiotic, is a cytotoxic agent that causes double-strand DNA breaks. Calicheamicin is a DNA synthesis inhibitor. Research Area：Cancer|Infection Targets：DNA Alkylator/Crosslinker|ADC Cytotoxin|Bacterial|Antibiotic|Apoptosis Related Screening Libraries:Bioactive Compound Library Plus;Toxins for Antibody-Drug Conjugate Research Library; Related Small Molecules:Physalin A;Bomedemstat […]