Tag: Inducer|Inhibitor

For research use only. We do not sell to patients. Imatinib-d8 CAS No. : 1092942-82-9 Biological Activity：Imatinib D8 (STI571 D8) is a deuterium labeled Imatinib (STI571). Imatinib is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity[2]. Research Area：Cancer Targets：Autophagy|Bcr-Abl|c-Kit|PDGFR|SARS-CoV Related Small Molecules:AT9283;Bafetinib;Pivanex;Henatinib;SARS-CoV-2-IN-33;GRL-0496;SNIPER(ABL)-039;c-Kit-IN-5-1;Flumatinib mesylate;IHMT-TRK-284;Grazoprevir potassium salt;PDGFRα/FLT3-ITD-IN-2;SARS-CoV-2-IN-19;Molnupiravir;SARS-CoV-2 Mpro-IN-3;MM3122;Ketotifen fumarate;PP58;Chiauranib;SARS-CoV-2-IN-16;Zeteletinib […]

For research use only. We do not sell to patients. EGFR-IN-57 CAS No. : 2492382-37-1 Biological Activity：EGFR-IN-57 (Compound 25a) is a potent, orally active EGFR-TK inhibitor with an IC50 of 0.054 µM. EGFR-IN-57 also inhibits VEGFR-2, CK2α, topoisomerase IIβ and tubulin polymerization with IC50 values of 0.087, 0.171, 0.13 and 3.61 µM, respectively. EGFR-IN-57 induces […]

For research use only. We do not sell to patients. Lidocaine-d10 CAS No. : 851528-09-1 Biological Activity：Lidocaine-d10 is the deuterium labeled Lidocaine. Lidocaine (Lignocaine) inhibits sodium channels involving complex voltage and using dependence. Lidocaine decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling […]

For research use only. We do not sell to patients. YM458 Biological Activity：YM458 is a potent EZH2 and BRD4 dual inhibitor with IC50s of 490 nM and 34 nM, respectively. YM458 inhibits cell proliferation and colony formation and induces cell cycle arrest and apoptosis in solid cancer cells. YM458 can be used for researching anticancer. […]

For research use only. We do not sell to patients. Mps-BAY2a CAS No. : 1382477-96-4 Biological Activity：Mps-BAY2a is a monopolar spindle 1 (MPS1) inhibitor with an IC50 of 1 nM against human MPS1. Mps-BAY2a induces mitotic aberrations and apoptosis in cancer cells. Research Area：Cancer Targets：Mps1|Apoptosis Related Screening Libraries:Bioactive Compound Library Plus; Related Small Molecules:Physalin A;Bomedemstat […]

For research use only. We do not sell to patients. MI-192 CAS No. : 1415340-63-4 Biological Activity：MI-192 is a selective HDAC2 and HDAC3 inhibitor with IC50s of 30 nM and 16 nM, respectively. MI-192 is more selective for HDAC2/3 than other HDAC isomers.MI-192 induces myeloid leukaemic cells apoptosis. Anticaner and neuroprotective activities[2]. Research Area：Cancer|Neurological Disease […]

For research use only. We do not sell to patients. Ciprofloxacin lactate CAS No. : 97867-33-9 Biological Activity：Ciprofloxacin (Bay-09867) lactate is a potent, orally active topoisomerase IV inhibitor. Ciprofloxacin lactate induces mitochondrial DNA and nuclear DNA damage and lead to mitochondrial dysfunction, ROS production. Ciprofloxacin lactate has anti-proliferative activity and induces apoptosis. Ciprofloxacin lactate is […]

For research use only. We do not sell to patients. Microtubule inhibitor 2 Biological Activity：Microtubule inhibitor 2 is a potent and selective, orally active microtubule inhibitor. Microtubule inhibitor 2 triggers cell death through ferroptosis . Microtubule inhibitor 2 shows antitumor activity. Research Area：Cancer Targets：Ferroptosis|Microtubule/Tubulin Related Small Molecules:CIL56;DB0614;Tirbanibulin dihydrochloride;Tilavonemab;Ciclopirox-d11;Ciclopirox olamine;Curcumin;Tau tracer 1;Dolastatin 10;Ceratamine A;Batabulin sodium;OXi8007;Antitumor agent-68;Dictyostatin;Tubulin […]

For research use only. We do not sell to patients. ZLWT-37 Biological Activity：ZLWT-37 is a potent, orally active CDKs inhibitor with IC50 values of 0.002 μM and 0.054 μM against CDK9 and CDK2, respectively. ZLWT-37 induces apoptosis and arrests the cell cycle in the G2/M phase in HCT116 cells. Research Area：Cancer Targets：CDK|Apoptosis Related Small Molecules:Physalin […]

For research use only. We do not sell to patients. IDO1/TDO-IN-1 CAS No. : 2379527-72-5 Biological Activity：IDO1/TDO-IN-1 (30) is a potent dual IDO1 (uncompetitive, Ki of 0.23 μM) and TDO (competitive, Ki of 0.73 μM) inhibitor. IDO1/TDO-IN-1 (30) significantly promotes cell apoptosis through the potential mitochondria-mediated Bcl-2/Bax pathway. Research Area：Cancer Targets：Indoleamine 2,3-Dioxygenase (IDO)|Bcl-2 Family|Apoptosis Related […]