Tag: Inducer|Inhibitor

For research use only. We do not sell to patients. Deguelin CAS No. : 522-17-8 Biological Activity：Deguelin, a naturally occurring rotenoid, acts as a chemopreventive agent by blocking multiple pathways like PI3K-Akt, IKK-NF-κB, and MAPK-mTOR-survivin-mediated apoptosis. Deguelin binding to Hsp90 leads to a decreased expression of numerous oncogenic proteins, including MEK1/2, Akt, HIF1α, COX-2, and […]

For research use only. We do not sell to patients. Ramipril-d5 CAS No. : 1132661-86-9 Biological Activity：Ramipril-d5 is the deuterium labeled Ramipril. Ramipril (HOE-498) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 5 nM. Research Area：Cardiovascular Disease Targets：Angiotensin-converting Enzyme (ACE)|Apoptosis Related Small Molecules:Physalin A;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;BJE6-106;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor 3;Xevinapant;Mangiferin;Cambinol;Antioxidant agent-5;Apoptosis inducer 9;Bafetinib;Cyclovirobuxine D;STAT3-IN-10;Rigosertib […]

For research use only. We do not sell to patients. Quercitrin CAS No. : 522-12-3 Biological Activity：Quercitrin is a natural compound found in widespread with a potential anti-inflammation effect that is used to treat heart and vascular conditions. IC50 value: Target: In vitro: There were significant increases in caspase-3 activity, loss of MMP, and increases […]

For research use only. We do not sell to patients. PIM-447 dihydrochloride CAS No. : 1820565-69-2 Biological Activity：PIM447 dihydrochloride (LGH447 dihydrochloride) is a potent, orally available, and selective pan-PIM kinase inhibitor, with Ki values of 6, 18, and 9 pM for PIM1, PIM2, and PIM3, respectively. PIM447 dihydrochloride displays dual antimyeloma and bone-protective effects. PIM447 […]

For research use only. We do not sell to patients. Pyrogallol CAS No. : 87-66-1 Biological Activity：Pyrogallol is a polyphenol compound, which has anti-fungal and anti-psoriatic properties. Pyrogallol is a reductant that is able to generate free radicals, in particular superoxide anions. Research Area：Infection Targets：Fungal|Endogenous Metabolite|Apoptosis Related Screening Libraries:Natural Product Library Plus;Bioactive Compound Library Plus;Anti-Infection […]

For research use only. We do not sell to patients. (+)-Usnic acid CAS No. : 7562-61-0 Biological Activity：(+)-Usnic acid is isolated from isolated from lichens, binds at the ATP-binding pocket of mTOR, and inhibits mTORC1/2 activity. (+)-Usnic acid inhibits the phosphorylation of mTOR downstream effectors: Akt (Ser473), 4EBP1, S6K, induces autophay, with anti-cancer activity. (+)-Usnic […]

For research use only. We do not sell to patients. Carvedilol CAS No. : 72956-09-3 Biological Activity：Carvedilol (BM 14190) is a non-selective β/α-1 blocker. Carvedilol inhibits lipid peroxidation in a dose-dependent manner with an IC50 of 5 μM. Carvedilol is a multiple action antihypertensive agent with potential use in angina and congestive heart failure[2]. Carvedilol […]

For research use only. We do not sell to patients. 8-Aminoadenosine CAS No. : 3868-33-5 Biological Activity：8-Aminoadenosine (8-NH2-Ado), a RNA-directed nucleoside analogue, reduces cellular ATP levels and inhibits mRNA synthesis. 8-Aminoadenosine blocks Akt/mTOR signaling and induces autophagy and apoptosis in a p53-independent manner. 8-Aminoadenosine has antitumor activity[2][3]. Research Area：Cancer Targets：Akt|Autophagy|mTOR|DNA/RNA Synthesis|Apoptosis Related Small Molecules:D-α-Hydroxyglutaric acid […]

For research use only. We do not sell to patients. α-Lipoic Acid sodium CAS No. : 2319-84-8 Biological Activity：α-Lipoic Acid (Thioctic acid) sodium is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid sodium inhibits NF-κB-dependent HIV-1 LTR activation[2][3]. α-Lipoic Acid sodium induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells[4]. […]

For research use only. We do not sell to patients. Dacomitinib-d5 Biological Activity：Dacomitinib-d5 (PF-00299804-d5) is the deuterium labeled Dacomitinib. Dacomitinib (PF-00299804) is a specific and irreversible inhibitor of the ERBB family of kinases with IC50s of 6 nM, 45.7 nM and 73.7 nM for EGFR, ERBB2, and ERBB4, respectively. Research Area：Cancer Targets：EGFR|Apoptosis Related Small Molecules:Physalin […]