Tag: Inducer|Inhibitor

For research use only. We do not sell to patients. Glyburide-d11 CAS No. : 1189985-02-1 Biological Activity：Glyburide-d11 is the deuterium labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor and can be used for the research of diabetes and obesity. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits […]

For research use only. We do not sell to patients. Tubulin inhibitor 30 Biological Activity：Tubulin inhibitor 30 (Compound 15) is a tubulin assembly inhibitor with an IC50 of 0.52 μM. Tubulin inhibitor 30 can induce ferroptosis. Research Area：Cancer Targets：Ferroptosis|Microtubule/Tubulin Related Small Molecules:CIL56;DB0614;Tirbanibulin dihydrochloride;Tilavonemab;Ciclopirox-d11;Ciclopirox olamine;Curcumin;Tau tracer 1;Dolastatin 10;Ceratamine A;Batabulin sodium;OXi8007;Antitumor agent-68;Dictyostatin;Tubulin inhibitor 6;(-)-Epicatechin;Oryzalin;Eugenol-d3;Tubulin inhibitor 25;Fmoc-MMAE;Taltobulin Trending […]

For research use only. We do not sell to patients. CHMFL-ABL-121 CAS No. : 2270879-07-5 Biological Activity：CHMFL-ABL-121 is a highly potent type II ABL kinase inhibitor with IC50s of 2 nM and 0.2 nM against purified inactive ABL wt and T315I kinase protein, respectively. Research Area：Cancer Targets：Bcr-Abl|Apoptosis Related Small Molecules:Physalin A;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;BJE6-106;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II […]

For research use only. We do not sell to patients. Cabozantinib hydrochloride CAS No. : 1817759-42-4 Biological Activity：Cabozantinib hydrochloride is a potent and orally active inhibitor of VEGFR2 and MET, with IC50 values of 0.035 and 1.3 nM, respectively. Cabozantinib hydrochloride displays strong inhibition of KIT, RET, AXL, TIE2, and FLT3 (IC50=4.6, 5.2, 7, 14.3, […]

For research use only. We do not sell to patients. EGFR-IN-44 Biological Activity：EGFR-IN-44 (Compound 6a) is a potent, orally active EGFR tyrosine kinase inhibitor with an IC50 of 4.11 nM. EGFR-IN-44 induces cell apoptosis and shows an oral bioavailability value of 33.57%. EGFR-IN-44 can be studied for non-small-cell lung cancers. Research Area：Cancer Targets：EGFR|Apoptosis Related Small […]

For research use only. We do not sell to patients. β-NETA CAS No. : 31059-54-8 Biological Activity：β-NETA is a potent and noncompetitive choline acetyltransferase (ChA; IC50=76 μM) and cholinesterase (ChE; IC50=40 µM) inhibitor. β-NETA weakly inhibits acetylcholinesterase (AChE; IC50=1 mM)[2]. Research Area：Cancer Targets：Cholinesterase (ChE)|Apoptosis Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Neuronal Signaling Compound Library;Anti-Cancer […]

For research use only. We do not sell to patients. EGFR/HER2-IN-6 Biological Activity：EGFR/HER2-IN-6 (compound 43) is an EGFR/HER2 and DHFR inhibitor. EGFR/HER2-IN-6 inhibits EGFR kinase, HER2 kinase and DHFR with IC50s of 0.122, 0.078 and 0.585 μM, respectively. EGFR/HER2-IN-6 shows anticancer activity against several cancer cell lines with high safety profile and selectivity indices. EGFR/HER2-IN-8 […]

For research use only. We do not sell to patients. Pantoprazole sodium CAS No. : 138786-67-1 Biological Activity：Pantoprazole sodium (BY10232 sodium) is an orally active and potent proton pump inhibitor (PPI). Pantoprazole sodium, a substituted benzimidazole, is a potent H+/K+-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole sodium improves pH stability and has anti-secretory, […]

For research use only. We do not sell to patients. Nenocorilant CAS No. : 1496509-78-4 Biological Activity：Nenocorilant (Relacorilant) is a potent, orally activity glucocorticoid receptor (GR) antagonist with Ki value of 0.15 nM. Nenocorilant has pro-apoptotic effects and improves potency combined with cytotoxic agent. Nenocorilant can be used for cancer research[2][3]. Research Area：Cancer Targets：Glucocorticoid Receptor|Caspase|Apoptosis […]

For research use only. We do not sell to patients. Kongensin A CAS No. : 885315-96-8 Biological Activity：Kongensin A is a natural product isolated from Croton kongensis. Kongensin A is an effective, covalent HSP90 inhibitor that blocks RIP3-dependent necroptosishas. Kongensin A is a potent necroptosis inhibitor and an apoptosis inducer. Kongensin A has potential anti-necroptosis […]