Tag: Inducer|Inhibitor

For research use only. We do not sell to patients. Stavudine-d4 CAS No. : 1219803-67-4 Biological Activity：Stavudine-d4 is the deuterium labeled Stavudine. Stavudine (d4T) is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Stavudine has activity against HIV-1 and HIV-2. Stavudine also inhibits the replication of mitochondrial DNA (mtDNA). Stavudine reduces NLRP3 inflammasome activation and […]

For research use only. We do not sell to patients. LSD1-IN-14 CAS No. : 2698340-11-1 Biological Activity：LSD1-IN-14 is a potent and selective LSD1 inhibitor (IC50=0.89 μM). LSD1-IN-14 can significantly inhibit the proliferation of A549 and THP-1 cells and induce the apoptosis of tumor cells. Research Area：Cancer Targets：Apoptosis|Histone Demethylase Related Small Molecules:Physalin A;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;BJE6-106;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase […]

For research use only. We do not sell to patients. Telaglenastat CAS No. : 1439399-58-2 Biological Activity：Telaglenastat (CB-839) is a first-in-class, selective, reversible and orally active glutaminase 1 (GLS1) inhibitor. Telaglenastat selectively inhibits GLS1 splice variants KGA (kidney-type glutaminase) and GAC (glutaminase C) compared to GLS2. The IC50s are 23 nM and 28 nM for […]

For research use only. We do not sell to patients. CPTH2 CAS No. : 357649-93-5 Biological Activity：CPTH2 is a potent histone acetyltransferase (HAT) inhibitor. CPTH2 selectively inhibits the acetylation of histone H3 by Gcn5. CPTH2 induces apoptosis and decreases the invasiveness of a clear cell renal carcinoma (ccRCC) cell line through the inhibition of acetyltransferase […]

For research use only. We do not sell to patients. HSP90/mTOR-IN-1 Biological Activity：HSP90/mTOR-IN-1 is a potent and orally active Hsp90 and mTOR inhibitor with IC50 values of 69 nM and 29 nM, respectively. HSP90/mTOR-IN-1 suppresses the proliferation of SW780 cells through the over-activation of the PI3K/AKT/mTOR pathway. HSP90/mTOR-IN-1 induces apoptosis and autophagy via selective Hsp90 […]

For research use only. We do not sell to patients. MG-132 CAS No. : 133407-82-6 Biological Activity：MG-132 (Z-Leu-Leu-Leu-al) is a potent proteasome and calpain inhibitor with IC50s of 100 nM and 1.2 μM, respectively. MG-132 effectively blocks the proteolytic activity of the 26S proteasome complex. MG-132, a peptide aldehyde, also is an autophagy activator. MG-132 […]

For research use only. We do not sell to patients. SB 415286 CAS No. : 264218-23-7 Biological Activity：SB 415286 is a potent and selective cell permeable inhibitor of GSK-3α, with an IC50 of 77.5 nM, and a Ki of 30.75 nM; SB 415286 is equally effective at inhibiting human GSK-3α and GSK-3β. Research Area：Metabolic Disease […]

For research use only. We do not sell to patients. VAS 3947 CAS No. : 869853-70-3 Biological Activity：VAS 3947, a specific NADPH oxidase (NOX) inhibitor, exerts a potent antiplatelet effect. VAS3947 induces apoptosis independently of anti-NOX activity, via UPR activation, mainly due to aggregation and misfolding of proteins[2]. Research Area：Cancer|Cardiovascular Disease Targets：NADPH Oxidase|Apoptosis Related Screening […]

For research use only. We do not sell to patients. 7,3′,4′-Trihydroxyisoflavone CAS No. : 485-63-2 Biological Activity：7,3′,4′-Trihydroxyisoflavone, a major metabolite of Daidzein, is an ATP-competitive inhibitor of Cot (Tpl2/MAP3K8) and MKK4. 7,3′,4′-Trihydroxyisoflavone has anticancer, anti-angiogenic, chemoprotective, and free radical scavenging activities[2]. Research Area：Cancer Targets：MAP3K|Apoptosis Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Immunology/Inflammation Compound Library;Kinase Inhibitor […]

For research use only. We do not sell to patients. NVP-TNKS656 CAS No. : 1419949-20-4 Biological Activity：NVP-TNKS656 is a highly potent, selective, and orally active TNKS2 inhibitor with IC50 of 6 nM, and is > 300 fold selectivity against PARP1 and PARP2. Research Area：Cancer Targets：PARP|Apoptosis Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Cell Cycle/DNA Damage […]