Tag: Inducer|Inhibitor

For research use only. We do not sell to patients. RET-IN-11 Biological Activity：RET-IN-11 is a potent and selective RET inhibitor with IC50s of 6.20 nM, 18.68 nM for RET and RETV804M, respectively. RET-IN-11 shows anti-proliferation and migration activity in CCDC6-RET-driven LC-2/ad cells. RET-IN-11 induces cell apoptosis. Research Area：Cancer Targets：RET|Apoptosis Related Small Molecules:Physalin A;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;BJE6-106;Dinaciclib;Ecteinascidin […]

For research use only. We do not sell to patients. Bafilomycin A1 CAS No. : 88899-55-2 Biological Activity：Bafilomycin A1 (BafA1) is a specific and reversible inhibitor of vacuolar H+-ATPase (V-ATPase) with IC50 values of 4-400 nmol/mg. Bafilomycin A1, a macrolide antibiotic, is also used as an autophagy inhibitor at the late stage. Bafilomycin A1 blocks […]

For research use only. We do not sell to patients. Puromycin aminonucleoside CAS No. : 58-60-6 Biological Activity：Puromycin aminonucleoside (NSC 3056) is the aminonucleoside portion of the antibiotic puromycin, and used in nephrosis animal models. Puromycin aminonucleoside induces apoptosis[2]. Puromycin aminonucleoside is a reversible inhibitor of dipeptidyl peptidase II and cytosol alanyl aminopeptidase[3]. Puromycin aminonucleoside […]

For research use only. We do not sell to patients. Temsirolimus CAS No. : 162635-04-3 Biological Activity：Temsirolimus is an inhibitor of mTOR with an IC50 of 1.76 μM. Temsirolimus activates autophagy and prevents deterioration of cardiac function in animal model[8]. Research Area：Cancer Targets：Autophagy|mTOR|Bacterial|Apoptosis Related Screening Libraries:Covalent Screening Library Plus;Drug Repurposing Compound Library Plus;FDA-Approved Drug Library […]

For research use only. We do not sell to patients. Erlotinib mesylate CAS No. : 248594-19-6 Biological Activity：Erlotinib mesylate (CP-358774 mesylate) inhibits purified EGFR kinase with an IC50 of 2 nM. Research Area：Cancer Targets：EGFR|Autophagy Related Small Molecules:NSC81111;pp60 (v-SRC) Autophosphorylation Site, Phosphorylated;BMS-690514;Osimertinib-13C,d3;EGFR-IN-5;FGFR2-IN-3;Genistein;Epertinib hydrochloride;UNC-CA359;Osimertinib mesylate;AV-412 free base;Nelipepimut-S;Falnidamol;HER2-IN-6;PROTAC EGFR degrader 7;CHMFL-EGFR-202;Avitinib;Naquotinib;Lavendustin A;EAI001;EGFR/HER2/CDK9-IN-2;Cyasterone;DP-C-4;Allitinib Trending products：Recombinant Proteins  |  Bioactive Screening […]

For research use only. We do not sell to patients. Tofacitinib-d3 citrate CAS No. : 2701680-77-3 Biological Activity：Tofacitinib-d3 (citrate) is deuterium labeled Tofacitinib (citrate). Tofacitinib citrate is an orally available JAK1/2/3 inhibitor with IC50s of 1, 20, and 112 nM, respectively. Tofacitinib citrate has antibacterial, antifungal and antiviral activities. Research Area：Cancer|Infection|Inflammation/Immunology Targets：JAK|Fungal|Influenza Virus|Bacterial|Apoptosis Related Small […]

For research use only. We do not sell to patients. Picroside II CAS No. : 39012-20-9 Biological Activity：Picroside II, an iridoid compound extracted from Picrorhiza, exhibits anti-inflammatory and anti-apoptotic activities. picroside II alleviates the inflammatory response in sepsis and enhances immune function by inhibiting the activation of NLRP3 inflammasome and NF-κB pathways. Picroside II is […]

For research use only. We do not sell to patients. Ro-3306 CAS No. : 872573-93-8 Biological Activity：Ro-3306 is a potent and selective inhibitor of CDK1, with Kis of 20 nM, 35 nM and 340 nM for CDK1, CDK1/cyclin B1 and CDK2/cyclin E, respectively. Research Area：Cancer Targets：CDK|Apoptosis Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Cell Cycle/DNA […]

For research use only. We do not sell to patients. Venetoclax-d8 CAS No. : 1257051-06-1 Biological Activity：Venetoclax-d8 is deuterium labeled Venetoclax. Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable Bcl-2 inhibitor with a Ki of less than 0.01 nM. Venetoclax induces autophagy[2][3]. Research Area：Cancer Targets：Autophagy|Bcl-2 Family Related Small Molecules:BI-3812;Pyridoclax;PUMA BH3 TFA;Dehydrocorydaline;Bufarenogin;Murizatoclax;Obatoclax;CYD-2-11;BM 957;(S)-Gossypol […]

For research use only. We do not sell to patients. Multi-kinase-IN-2 CAS No. : 2095628-21-8 Biological Activity：Multi-kinase-IN-2 (compound 7h) is an orally active and potent angiokinase inhibitor. Multi-kinase-IN-2 exhibits excellent inhibitory activity against angiokinases including VEGFR-1/2/3, PDGFRα/β, and FGFR-1, as well as LYN and c-KIT kinases. Multi-kinase-IN-2 significantly attenuates phosphorylation of AKT and ERK proteins. […]