Tag: Inducer|Inhibitor

For research use only. We do not sell to patients. Dasatinib CAS No. : 302962-49-8 Biological Activity：Dasatinib (BMS-354825) is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent antitumor activity. The Kis are 16 pM and 30 pM for Src and Bcr-Abl, respectively. Dasatinib inhibits Bcr-Abl and Src with IC50s of

For research use only. We do not sell to patients. Stattic CAS No. : 19983-44-9 Biological Activity：Stattic is a potent STAT3 inhibitor and inhibits STAT3 phosphorylation (at Y705 and S727). Stattic inhibits the binding of a high affinity phosphopeptide for the SH2 domain of STAT3[2]. Stattic ameliorates the renal dysfunction in Alport syndrome (AS) mice[3]. […]

For research use only. We do not sell to patients. Temsirolimus-d3-1 CAS No. : 936084-13-8 Biological Activity：Temsirolimus-d3-1 (CCI-779-d3-1) is the deuterium labeled Temsirolimus. Temsirolimus is an inhibitor of mTOR with an IC50 of 1.76 μM. Temsirolimus activates autophagy and prevents deterioration of cardiac function in animal model[8]. Research Area：Cancer Targets：Autophagy|mTOR|Apoptosis Related Small Molecules:D-α-Hydroxyglutaric acid disodium;Physalin […]

For research use only. We do not sell to patients. Nilotinib monohydrochloride monohydrate CAS No. : 923288-90-8 Biological Activity：Nilotinib monohydrochloride monohydrate is a second generation tyrosine kinase inhibitor (TKI), is significantly potent against BCR-ABL, and is active against many BCR-ABL mutants. Research Area：Cancer Targets：Autophagy|Bcr-Abl Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug […]

For research use only. We do not sell to patients. Cycleanine CAS No. : 518-94-5 Biological Activity：Cycleanine is a potent vascular selective Calcium antagonist. Cycleanine has analgesic, muscle relaxant and anti-inflammatory activities. Cycleanine has potential for anti-ovarian cancer acting through the apoptosis pathway[2]. Research Area：Cancer|Inflammation/Immunology Targets：Calcium Channel|Apoptosis Related Screening Libraries:Natural Product Library Plus;Bioactive Compound Library […]

For research use only. We do not sell to patients. CCT018159 CAS No. : 171009-07-7 Biological Activity：CCT018159, a 3,4-diaryl pyrazoleresorcinol, is a ATP-competitive HSP90 ATPase activity inhibitor with IC50s of 3.2 and 6.6 µM for human Hsp90β and yeast Hsp90, respectively. CCT018159 caused cell cytostasis associated with a G1 arrest and induces apoptosis. CCT018159 inhibits […]

For research use only. We do not sell to patients. SC66 CAS No. : 871361-88-5 Biological Activity：SC66 is an Akt inhibitor, reduces cell viability in a dose- and time-dependent manner, inhibits colony formation and induces apoptosis in hepatocellular carcinoma (HCC) cells. Research Area：Cancer Targets：Akt|Apoptosis Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Kinase Inhibitor Library;PI3K/Akt/mTOR Compound […]

For research use only. We do not sell to patients. Ascochlorin CAS No. : 26166-39-2 Biological Activity：Ascochlorin (Ilicicolin D), an isoprenoid antibiotic, mediates its anti-tumor effects predominantly through the suppression of STAT3 signaling cascade. Ascochlorin induces apoptosis. Anti-inflammatory activity[2][3]. Research Area：Cancer|Inflammation/Immunology Targets：STAT|Antibiotic|Apoptosis Related Small Molecules:Physalin A;Bomedemstat ditosylate;Sandramycin;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Oritavancin;Lobetyolin;Monascorubrin;Azlocillin sodium salt;Herbimycin A;Leucomycin;BJE6-106;Dinaciclib;Cirsilineol;Ecteinascidin 770;MDM2-p53-IN-15;Vidarabine monohydrate;Nafcillin;Ochromycinone;AT9283;Staurosporine Trending products：Recombinant […]

For research use only. We do not sell to patients. Antitumor agent-70 CAS No. : 2454133-88-9 Biological Activity：Antitumor agent-70 (compound 8b) has anti-tumor activity and can induce cell apoptosis. Antitumor agent-70 inhibits multiple myeloma with an IC50 value of 0.12 μM. Antitumor agent-70 is a potential multi-targeted kinase inhibitor especially for c-Kit. Research Area：Cancer Targets：c-Kit|Apoptosis […]

For research use only. We do not sell to patients. Infigratinib CAS No. : 872511-34-7 Biological Activity：Infigratinib (BGJ-398; NVP-BGJ398) is a potent inhibitor of the FGFR family with IC50s of 0.9 nM, 1.4 nM, 1 nM, and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively. Research Area：Cancer Targets：FGFR|Apoptosis Related Screening Libraries:Drug Repurposing Compound Library […]