Tag: Inducer|Inhibitor

For research use only. We do not sell to patients. Triptolide-d3 Biological Activity：Triptolide-d3 (PG490-d3) is the deuterium labeled Triptolide. Triptolide is a diterpenoid triepoxide extracted from the root of Tripterygium wilfordii with immunosuppressive, anti-inflammatory, antiproliferative and antitumour effects. Triptolide is a NF-κB activation inhibitor[2][3][4][5][6]. Research Area：Cancer Targets：NF-κB|Apoptosis Related Small Molecules:Physalin A;Bomedemstat ditosylate;Akt/NF-κB/JNK-IN-1;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;Icariside F2;BJE6-106;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;IKKγ […]

For research use only. We do not sell to patients. 6-Thioguanine CAS No. : 154-42-7 Biological Activity：6-Thioguanine (Thioguanine; 2-Amino-6-purinethiol) is an anti-leukemia and immunosuppressant agent, acts as an inhibitor of SARS and MERS coronavirus papain-like proteases (PLpros) and also potently inhibits USP2 activity, with IC50s of 25 μM and 40 μM for Plpros and recombinant […]

For research use only. We do not sell to patients. Disulfiram CAS No. : 97-77-8 Biological Activity：Disulfiram (Tetraethylthiuram disulfide) is a specific inhibitor of aldehyde-dehydrogenase (ALDH1), used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in […]

For research use only. We do not sell to patients. Indinavir CAS No. : 150378-17-9 Biological Activity：Indinavir (MK-639 free base) is an orally active and selective HIV-1 protease inhibitor with a Ki of 0.54 nM for PR. Indinavir exhibits anticancer activity by inhibiting the activation of MMPs-2 hydrolysis, anti-angiogenesis and inducing apoptosis. Indinavir is also […]

For research use only. We do not sell to patients. SU9516 CAS No. : 377090-84-1 Biological Activity：SU9516 is a potent CDK2 inhibitor, with an IC50 of 22 nM, and also shows inhibitory effects on CDK1 and CDK4, with IC50s of 40, 200 nM, respectively. Research Area：Cancer Targets：Autophagy|CDK|Apoptosis Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Cell […]

For research use only. We do not sell to patients. Metronidazole-d4 CAS No. : 1261392-47-5 Biological Activity：Metronidazole-d4 is the deuterium labeled Metronidazole. Metronidazole is a nitroimidazole antibiotic medication used particularly for anaerobic bacteria and protozoa. Research Area：Infection Targets：Parasite|Bacterial|Antibiotic|Apoptosis Related Small Molecules:Physalin A;(+)-Isopulegol;Bomedemstat ditosylate;Sandramycin;LLO (91-99);Gepotidacin;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Oritavancin;Lobetyolin;Monascorubrin;SR9186;Antileishmanial agent-2;Azlocillin sodium salt;Herbimycin A;Antibacterial agent 45;Leucomycin;Isouvaretin Trending products：Recombinant Proteins  |  […]

For research use only. We do not sell to patients. Rottlerin CAS No. : 82-08-6 Biological Activity：Rottlerin, a natural product purified from Mallotus Philippinensis, is a specific PKC inhibitor, with IC50 values for PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-100 μM. Rottlerin acts as a direct mitochondrial uncoupler, and stimulates autophagy […]

For research use only. We do not sell to patients. Verbascoside CAS No. : 61276-17-3 Biological Activity：Verbascoside is isolated from Acanthus mollis, acts as an ATP-competitive inhibitor of PKC, with an IC50 of 25 µM, and has antitumor, anti-inflammatory and antineuropathic pain activity. Research Area：Cancer|Inflammation/Immunology|Neurological Disease Targets：HSV|PKC|Bacterial|Apoptosis Related Screening Libraries:Natural Product Library Plus;Bioactive Compound Library […]

For research use only. We do not sell to patients. mTOR/HDAC6-IN-1 Biological Activity：mTOR/HDAC6-IN-1 is a potent mTOR and HDAC6 dual inhibitor (IC50s of 133.7 nM and 56 nM for mTOR and HDAC6, respectively). mTOR/HDAC6-IN-1 can induce significant autophagy, apoptosis and suppress migration. mTOR/HDAC6-IN-1 has potential to research Triple-negative breast cancer (TNBC). Research Area：Cancer Targets：Autophagy|mTOR|HDAC|Apoptosis Related […]

For research use only. We do not sell to patients. AZD0156 CAS No. : 1821428-35-6 Biological Activity：AZD0156 is a potent, selective and orally active ATM inhibitor with an IC50 of 0.58 nM. AZD0156 inhibits the ATM-mediated signaling, prevents DNA damage checkpoint activation, disrupts DNA damage repair, and induces tumor cell apoptosis. Research Area：Cancer Targets：ATM/ATR|Apoptosis Related […]