Tag: Inducer|Inhibitor

For research use only. We do not sell to patients. Dipyrithione CAS No. : 3696-28-4 Biological Activity：Dipyrithione is a potent antimicrobial agent. Dipyrithione shows antifungal activity and antiproliferative activity. Dipyrithione induces apoptosis and cycle arrest at G1 phase. Dipyrithione shows anti-inflammatory activity in vivo. Dipyrithione shows anti-tumor activity. Dipyrithione has the potential for the research […]

For research use only. We do not sell to patients. Zebularine CAS No. : 3690-10-6 Biological Activity：Zebularine (NSC309132; 4-Deoxyuridine) is a DNA methyltransferase inhibitor. Zebularine also inhibits cytidine deaminase with a Ki of 0.95 μM. Research Area：Cancer Targets：Autophagy|DNA Methyltransferase Related Screening Libraries:Covalent Screening Library Plus;Bioactive Compound Library Plus;Epigenetics Compound Library;Anti-Cancer Compound Library;Autophagy Compound Library;Covalent Screening […]

For research use only. We do not sell to patients. TAK-243 CAS No. : 1450833-55-2 Biological Activity：TAK-243 (MLN7243) is a first-in-class, selective ubiquitin activating enzyme, UAE (UBA1) inhibitor (IC50=1 nM), which blocks ubiquitin conjugation, disrupting monoubiquitin signaling as well as global protein ubiquitination. TAK-243 (MLN7243) induces endoplasmic reticulum (ER) stress, abrogates NF-κB pathway activation and […]

For research use only. We do not sell to patients. Tomatidine hydrochloride CAS No. : 6192-62-7 Biological Activity：Tomatidine hydrochloride acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling. Tomatidine hydrochloride activates autophagy either in mammal cells or C elegans[2]. Research Area：Inflammation/Immunology|Cardiovascular Disease Targets：Autophagy|NF-κB|Endogenous Metabolite|JNK Related Small Molecules:D-α-Hydroxyglutaric acid disodium;Nicotinamide N-oxide;3-Hydroxyglutaric acid-d5;DPPC-d62;SDMA-d6;2-Mercaptobenzothiazole;Akt/NF-κB/JNK-IN-1;N-Acetyl-L-glutamic acid-d5;(3R,5S)-3-Hydroxy Cotinine-d3;Biliverdin […]

For research use only. We do not sell to patients. TPB15 CAS No. : 2170347-69-8 Biological Activity：TPB15 is an orally active and potent Hh (Hedgehog) signaling inhibitor. TPB15 markedly induces cell cycle arrest and apoptosis in MDA-MB-468 cells. TPB15 blocks Smo (Smoothened) translocation into the cilia and reduced Smo protein and mRNA expression. TPB15 inhibits […]

For research use only. We do not sell to patients. Bruceine D CAS No. : 21499-66-1 Biological Activity：Bruceine D is a Notch inhibitor with anti-cancer activity and induces apoptosis in several human cancer cells. Bruceine D is an effective botanical insect antifeedant with outstanding systemic properties, causing potent pest growth inhibitory activity[2]. Bruceine D has […]

For research use only. We do not sell to patients. Xanthatin CAS No. : 26791-73-1 Biological Activity：Xanthatin is isolated from Xanthium strumarium leaves. Xanthatin exhibits strong antitumor activities against a variety of cancer cells through apoptosis persuasion and shows anti-inflammatory activities by inhibiting PGE2 synthesis and 5-lipoxygenase activity. Xanthatin is a potent and orally active inhibitor of VEGFR2 kinase activity with an IC50 […]

For research use only. We do not sell to patients. SU11274 CAS No. : 658084-23-2 Biological Activity：SU11274 is a selective Met inhibitor with IC50 of 10 nM, but has no effects on PGDFRβ, EGFR or Tie2. Research Area：Cancer Targets：Autophagy|c-Met/HGFR|Apoptosis Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Kinase Inhibitor Library;Protein Tyrosine Kinase Compound Library;Anti-Cancer Compound Library;Autophagy […]

For research use only. We do not sell to patients. Fenretinide CAS No. : 65646-68-6 Biological Activity：Fenretinide (4-HPR) is a synthetic retinoid deriverative, binding to the retinoic acid receptors (RAR) at concentrations necessary to induce cell death. Research Area：Cancer Targets：Autophagy|RAR/RXR Related Screening Libraries:Covalent Screening Library Plus;Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library […]

For research use only. We do not sell to patients. Tubulysin C CAS No. : 205304-88-7 Biological Activity：Tubulysin C is a highly cytotoxic peptide isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis. Tubulysin displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the lower nanomolar range. […]