Tag: Inducer|Inhibitor

For research use only. We do not sell to patients. Entrectinib CAS No. : 1108743-60-7 Biological Activity：Entrectinib (NMS-E628) is a potent, orally available, and CNS-active pan-Trk, ROS1, and ALK inhibitor. Entrectinib inhibits TrkA, TrkB, TrkC, ROS1 and ALK with IC50 values of 1, 3, 5, 12 and 7 nM, respectively. Antitumor activity. Research Area：Cancer Targets：Autophagy|Trk […]

For research use only. We do not sell to patients. Scutellarein CAS No. : 529-53-3 Biological Activity：Scutellarin, a main active ingredient extracted from Erigeron breviscapus (Vant.) Hand-Mazz., has been wildly used to treat acute cerebral infarction and paralysis induced by cerebrovascular diseases. Research Area：Inflammation/Immunology|Cancer Targets：Autophagy|Src|SARS-CoV Related Screening Libraries:Natural Product Library Plus;Bioactive Compound Library Plus;Anti-Infection Compound […]

For research use only. We do not sell to patients. Catechin CAS No. : 154-23-4 Biological Activity：Catechin ((+)-Catechin) inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM. Research Area：Cancer Targets：Influenza Virus|Endogenous Metabolite|Apoptosis|COX Related Screening Libraries:Natural Product Library Plus;Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;Anti-Infection Compound Library;Apoptosis Compound Library;Immunology/Inflammation […]

For research use only. We do not sell to patients. K-7174 CAS No. : 191089-59-5 Biological Activity：K-7174 is an orally active proteasome and GATA inhibitor. K-7174 is a cell adhesion inhibitor. K-7174 induces cell apoptosis. K-7174 shows antitumor activities, it can be used for the research of cancer[2][3]. Research Area：Cancer|Inflammation/Immunology Targets：Proteasome|Apoptosis Related Small Molecules:Physalin A;Bomedemstat […]

For research use only. We do not sell to patients. Butein CAS No. : 487-52-5 Biological Activity：Butein is a cAMP-specific PDE inhibitor with an IC50 of 10.4 μM for PDE4. Butein is a specific protein tyrosine kinase inhibitor with IC50s of 16 and 65 μM for EGFR and p60c-src in HepG2 cells[2]. Butein sensitizes HeLa […]

For research use only. We do not sell to patients. ARD-61 CAS No. : 2316837-08-6 Biological Activity：ARD-61 is a highly potent, effective and specific PROTAC androgen receptor (AR) degrader. ARD-61 potently and effectively induces AR and progesterone receptors (PR) degradation in AR+ cancer cell lines. ARD-61 induces apoptosis and effectively induces tumor growth inhibition in […]

For research use only. We do not sell to patients. PARP-1-IN-2 CAS No. : 684234-55-7 Biological Activity：PARP-1-IN-2 (compound 11g) is a potent and BBB-penetrated PARP1 inhibitor, with an IC50 of 149 nM. PARP1-IN-2 shows significantly potent anti-proliferative activity against Human lung adenocarcinoma epithelial cell line A549. PARP1-IN-2 can induce A549 cells apoptosis. Research Area：Cancer Targets：PARP|Caspase|Apoptosis […]

For research use only. We do not sell to patients. Dronedarone D6 hydrochloride CAS No. : 1329809-23-5 Biological Activity：Dronedarone D6 hydrochloride is the deuterium labeled Dronedarone. Dronedarone hydrochloride, a derivative of Amiodarone (HY-14187), is a class III antiarrhythmic agent for the study of atrial fibrillation (AF) and atrial flutter. Dronedarone hydrochloride is a potent blocker […]

For research use only. We do not sell to patients. Phenylbutyrate-d11 sodium CAS No. : 1392208-11-5 Biological Activity：Phenylbutyrate-d11 (sodium) is deuterium labeled Sodium 4-phenylbutyrate. Sodium 4-phenylbutyrate (4-PBA sodium) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research. Research Area：Cancer Targets：Autophagy|HDAC|Apoptosis Related Small Molecules:Physalin A;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;BJE6-106;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II […]

For research use only. We do not sell to patients. Nonactin CAS No. : 6833-84-7 Biological Activity：Nonactin is a naturally occurring macrotetrolide antibiotic from Streptomyces griseus. Nonactin acts as an ionophore for monovalent cations, including K+, and NH4+. Nonactin is able to uncouple the oxidative phosphorylation (OXPHOS) of mitochondria. Nonactin selectively induces apoptosis in cell […]