Tag: Inducer|Inhibitor

For research use only. We do not sell to patients. Ajoene CAS No. : 92285-01-3 Biological Activity：Ajoene, a garlic-derived compound, is an antithrombotic and antifungal agent. Ajoene inhibits proliferation and induces apoptosis of human leukaemia CD34-negative cells including HL-60, U937, HEL and OCIM-I. Anticancer activities[2]. Research Area：Cancer|Infection Targets：Fungal|Apoptosis Related Small Molecules:Antifungal agent 20;Physalin A;Bomedemstat ditosylate;Enpp/Carbonic […]

For research use only. We do not sell to patients. Metyrapone CAS No. : 54-36-4 Biological Activity：Metyrapone (Su-4885) is a potent and orally active 11β-hydroxylase inhibitor and an autophagy activator, also inhibits the production of aldosterone. Metyrapone inhibits synthesis of endogenous adrenal corticosteroid, decreases glucocorticoid levels, and also affects behavior and emotion. In addition, Metyrapone […]

For research use only. We do not sell to patients. PHA-793887 CAS No. : 718630-59-2 Biological Activity：PHA-793887 is a potent, ATP-competitive CDK inhibitor, can inhibit Cdk2, Cdk1, Cdk4, and Cdk9 with IC50s of 8 nM, 60 nM, 62 nM and 138 nM, respectively, and also inhibits glycogen synthase kinase 3β with an IC50 of 79 […]

For research use only. We do not sell to patients. (1S,2S)-Bortezomib-d5 CAS No. : 1133706-15-6 Biological Activity：(1S,2S)-Bortezomib-d5 is the deuterium labeled (1S,2S)-Bortezomib. (1S,2S)-Bortezomib is an enantiomer of Bortezomib. Bortezomib is a cell-permeable, reversible, and selective proteasome inhibitor, and potently inhibits 20S proteasome (Ki of 0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell […]

For research use only. We do not sell to patients. Tat-beclin 1 TFA Biological Activity：Tat-beclin 1 TFA, a peptide derived from a region of the autophagy protein (beclin 1), is a potent inducer of autophagy and interacts with negative regulator of autophagy, GAPR-1 (GLIPR2). Tat-beclin 1 TFA decreases the accumulation of polyglutamine expansion protein aggregates […]

For research use only. We do not sell to patients. Amiodarone hydrochloride CAS No. : 19774-82-4 Biological Activity：Amiodarone hydrochloride, a benzofuran-based Class III antiarrhythmic agent, inhibits WT outwardIhERG tails with an IC50 of ∼45 nM. Amiodarone hydrochloride induces cell proliferation and myofibroblast differentiation via ERK1/2 and p38 MAPK signaling in fibroblasts[2]. Amiodarone hydrochloride can be […]

For research use only. We do not sell to patients. Tubulin polymerization-IN-4 Biological Activity：Tubulin polymerization-IN-4 is a potent tubulin polymerization inhibitor with IC50 value of 4.6 μM. Tubulin polymerization-IN-4 can disrupt tubulin polymerization and vasculature, arrest the cell cycle at the G2/M phase, induce apoptosis, and suppress clonogenesis and migration in HeLa cells. Tubulin polymerization-IN-4 […]

For research use only. We do not sell to patients. ARN5187 CAS No. : 1287451-26-6 Biological Activity：ARN5187 is a lysosomotropic REV-ERBβ ligand with a dual inhibitory activity toward REV-ERB-mediated transcriptional regulation and autophagy. ARN5187 shows lysosomotropic potency and cytotoxicity. ARN5187 induces apoptosis[2]. Research Area：Cancer Targets：Autophagy|Apoptosis Related Small Molecules:Physalin A;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;BJE6-106;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor 3;Xevinapant;Mangiferin;Cambinol;Antioxidant […]

For research use only. We do not sell to patients. Ranolazine-d8 dihydrochloride CAS No. : 1219802-60-4 Biological Activity：Ranolazine-d8 (CVT 303-d8) dihydrochloride is the deuterium labeled Ranolazine dihydrochloride. Ranolazine dihydrochloride (CVT 303 dihydrochloride) is an anti-angina drug that achieves its effects by inhibiting the late phase of inward sodium current (INa and IKr with IC50 values […]

For research use only. We do not sell to patients. Tubulin inhibitor 14 Biological Activity：Tubulin inhibitor 14 is a potent NQO2 (quinone oxidoreductase 2) inhibitor with an IC50 of 1.0 μM. Tubulin inhibitor 14 also inhibits tubulin polymerization and the formation of endothelial cell capillary-like tubes. Tubulin inhibitor 14 is a microtubule-destabilizing agent with potential […]