Tag: Inducer|Inhibitor

For research use only. We do not sell to patients. Berbamine dihydrochloride CAS No. : 6078-17-7 Biological Activity：Berbamine dihydrochloride is an inhibitor of NF-κB activity with remarkable anti-myeloma efficacy. Research Area：Cancer Targets：Autophagy|NF-κB|Apoptosis Related Screening Libraries:Natural Product Library Plus;Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;Apoptosis Compound Library;Immunology/Inflammation Compound Library;NF-κB […]

For research use only. We do not sell to patients. Tofacitinib-13C3 Biological Activity：Tofacitinib-13C3 (Tasocitinib-13C3) is the 13C-labeled Tofacitinib. Tofacitinib is an orally available JAK3/2/1 inhibitor with IC50s of 1, 20, and 112 nM, respectively. Research Area：Inflammation/Immunology|Cancer Targets：JAK|Apoptosis Related Small Molecules:Physalin A;Bomedemstat ditosylate;AZ-3;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;JAK3/BTK-IN-1;BJE6-106;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor 3;Xevinapant;Benzene hexabromide;Mangiferin;Cambinol;Antioxidant agent-5;Apoptosis inducer 9;Bafetinib Trending products：Recombinant Proteins  |  […]

For research use only. We do not sell to patients. Epirubicin CAS No. : 56420-45-2 Biological Activity：Epirubicin (4′-Epidoxorubicin), a semisynthetic L-arabino derivative of doxorubicin, has an antineoplastic agent by inhibiting Topoisomerase. Epirubicin inhibits DNA and RNA synthesis. Epirubicin is a Forkhead box protein p3 (Foxp3) inhibitor and inhibits regulatory T cell activity[2]. Research Area：Cancer Targets：Topoisomerase|DNA/RNA […]

For research use only. We do not sell to patients. Bcl-2-IN-8 Biological Activity：Bcl-2-IN-8 is a potent anticancer agent. Bcl-2-IN-8 shows anti-proliferative activity against both drug-sensitive and drug-resistant cancer cells. Bcl-2-IN-8 induce apoptosis and cell cycle arrest at G1 phase. Bcl-2-IN-8 inhibits cell migration in a dose-dependent manner. Bcl-2-IN-8 has the potential for the research of […]

For research use only. We do not sell to patients. S65487 hydrochloride CAS No. : 1644543-95-2 Biological Activity：S65487 (VOB560) hydrochloride, a potent and selective Bcl-2 inhibitor, is a prodrug of S55746. S65487 hydrochloride is also active on BCL-2 mutations, such as G101V and D103Y. S65487 hydrochloride has poor affinity with MCL-1, BFL-1 and BCL-XL. S65487 […]

For research use only. We do not sell to patients. Ponatinib hydrochloride CAS No. : 1114544-31-8 Biological Activity：Ponatinib (AP24534) hydrochloride is a hydrochloride of ponatinib. Ponatinib is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively. […]

For research use only. We do not sell to patients. Mebendazole-d8 CAS No. : 1286787-80-1 Biological Activity：Mebendazole-d8 is the deuterium labeled Mebendazole. Mebendazole is a highly effective, broad-spectrum antihelmintic indicated for the treatment of nematode infestations; has been found as a hedgehog inhibitor[2]. Research Area：Infection|Cancer Targets：Parasite|Apoptosis Related Small Molecules:Physalin A;(+)-Isopulegol;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;SR9186;Antileishmanial agent-2;Azlocillin sodium salt;BJE6-106;Dinaciclib;Ecteinascidin […]

For research use only. We do not sell to patients. Indinavir sulfate ethanolate CAS No. : 2563866-80-6 Biological Activity：Indinavir sulfate ethanolate (MK-639 ethanolate) is an orally active and selective HIV-1 protease inhibitor with a Ki of 0.54 nM for PR. Indinavir sulfate ethanolate exhibits anticancer activity by inhibiting the activation of MMPs-2 hydrolysis, anti-angiogenesis and […]

For research use only. We do not sell to patients. Azoramide CAS No. : 932986-18-0 Biological Activity：Azoramide is a potent, orally active small-molecule modulator of the unfolded protein response (UPR). Azoramide improves ER protein folding and elevates ER chaperone capacity, which together protects cells against ER stress. Azoramide alleviates PLA2G6 mutant-induced ER stress through modulating […]

For research use only. We do not sell to patients. Cabozantinib CAS No. : 849217-68-1 Biological Activity：Cabozantinib is a potent and orally active inhibitor of VEGFR2 and MET, with IC50 values of 0.035, and 1.3 nM, respectively. Cabozantinib displays strong inhibition of KIT, RET, AXL, TIE2, and FLT3 (IC50=4.6, 5.2, 7, 14.3, and 11.3 nM, […]