Tag: Inducer|Inhibitor

For research use only. We do not sell to patients. Cabozantinib-d4 CAS No. : 1802168-53-1 Biological Activity：Cabozantinib-d4 is deuterium labeled Cabozantinib. Cabozantinib is a potent multiple receptor tyrosine kinases (RTKs) inhibitor that inhibits VEGFR2, c-Met, Kit, Axl and Flt3 with IC50s of 0.035, 1.3, 4.6, 7 and 11.3 nM, respectively. Research Area：Cancer Targets：FLT3|VEGFR|c-Met/HGFR|c-Kit|Apoptosis|TAM Receptor Related […]

For research use only. We do not sell to patients. Acetazolamide-13C2,d3 Biological Activity：Acetazolamide-13C2,d3 is the 13C- and deuterium labeled Acetazolamide. Acetazolamide is a carbonic anhydrase (CA) IX inhibitor with an IC50 of 30 nM for hCA IX. Diuretic effects[4]. Research Area：Cardiovascular Disease|Cancer Targets：Autophagy|Carbonic Anhydrase Related Small Molecules:Enpp/Carbonic anhydrase-IN-1;hCAIX-IN-8;Phenylsulfamide;Benzolamide;(E)-Dehydrodiconiferyl alcohol;hCAIX/XII-IN-1;CAXII-IN-1;hCAIX/XII-IN-2;hCAIX-IN-12;Girentuximab;hCAII-IN-2;hCAI/II-IN-1;hCAI/II-IN-4;Dichlorphenamide;hCAIX-IN-16;hCAII-IN-1;Sultiame;hCAII-IN-3;Carbonic anhydrase inhibitor 6;hCAXII-IN-4;hCAIX-IN-10;U-104;Carbonic anhydrase inhibitor 4;EMAC10101d […]

For research use only. We do not sell to patients. PAK4-IN-2 CAS No. : 2488706-33-6 Biological Activity：PAK4-IN-2 is a highly potent PAK4 inhibitor with IC50 value of 2.7 nM. PAK4-IN-2 can arrest MV4-11 cells at G0/G1 phase and induce cell apoptosis. PAK4-IN-2 can be used for researching cancer. Research Area：Cancer Targets：PAK|Apoptosis Related Small Molecules:Physalin A;Bomedemstat […]

For research use only. We do not sell to patients. Acetylcysteine-d3 CAS No. : 131685-11-5 Biological Activity：Acetylcysteine-d3 (N-Acetylcysteine-d3) is the deuterium labeled Acetylcysteine. Acetylcysteine (N-Acetylcysteine) is a mucolytic agent which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor[1]. Acetylcysteine is a cysteine precursor, prevents hemin-induced ferroptosis by neutralizing toxic lipids generated by […]

For research use only. We do not sell to patients. Vincristine-d3-ester sulfate CAS No. : 1217854-24-4 Biological Activity：Vincristine-d3-ester (Leurocristine-d3-ester) sulfate is the deuterium labeled Vincristine sulfate. Vincristine sulfate is an antitumor vinca alkaloid which inhibits microtubule formation in mitotic spindle, resulting in an arrest of dividing cells at the metaphase stage. It binds to microtubule […]

For research use only. We do not sell to patients. Topotecan CAS No. : 123948-87-8 Biological Activity：Topotecan (SKF 104864A; NSC 609669) is an orally active and potent Topoisomerase I inhibitor. Topotecan induces cell cycle arrest in G0/G1 and S phases and promotes apoptosis. Topotecan shows anticancer activity. Research Area：Cancer Targets：Topoisomerase|Autophagy|Apoptosis Related Small Molecules:Physalin A;Bomedemstat ditosylate;Gepotidacin;Enpp/Carbonic […]

For research use only. We do not sell to patients. Fimepinostat CAS No. : 1339928-25-4 Biological Activity：Fimepinostat (CUDC-907) potently inhibits class I PI3Ks as well as classes I and II HDAC enzymes with an IC50 of 19/54/39 nM and 1.7/5.0/1.8/2.8 nM for PI3Kα/PI3Kβ/PI3Kδ and HDAC1/HDAC2/HDAC3/HDAC10 , respectively. Research Area：Cancer Targets：HDAC|Apoptosis|PI3K Related Screening Libraries:Drug Repurposing Compound […]

For research use only. We do not sell to patients. AKT-IN-12 CAS No. : 2396718-52-6 Biological Activity：AKT-IN-12 (compound 3e) is a potent Akt kinase inhibitor with an IC50 value of 0.55 μM. AKT-IN-12 induces G0/G1 cell cycle arrest and apoptosis. AKT-IN-12 also inhibits p-AKT, p-ERK, and activates p-JNK, JNK. AKT-IN-12 can be used for researching […]

For research use only. We do not sell to patients. NF-κB-IN-5 CAS No. : 2425675-52-9 Biological Activity：NF-κB-IN-5 (compound 4d) is an orally active and potent NF-κB inhibitor by interacting directly with NF-κB. NF-κB-IN-5 shows antitumor activity against human cancer cell lines (HCT116, U87-MG, HepG2, BGC823, PC9), with IC50 values of 5.35, 2.81, 2.83, 2.02 and […]

For research use only. We do not sell to patients. Decitabine CAS No. : 2353-33-5 Biological Activity：Decitabine (NSC 127716) is an orally active deoxycytidine analogue antimetabolite and a DNA methyltransferase inhibitor. Decitabine incorporates into DNA in place of cytosine can covalently trap DNA methyltransferase to DNA causing irreversible inhibition of the enzyme. Decitabine induces cell […]