Tag: Inducer|Inhibitor

For research use only. We do not sell to patients. HDACs/mTOR Inhibitor 1 CAS No. : 2271413-06-8 Biological Activity：HDACs/mTOR Inhibitor 1 is a dual HDACs and mTOR inhibitor, with IC50s of 0.19 nM, 1.8 nM, 1.2 nM for HDAC1, HDAC6, mTOR, respectively. HDACs/mTOR Inhibitor 1 stimulates cell cycle arrest in G0/G1 phase and induces tumor […]

For research use only. We do not sell to patients. Ritonavir-d6 CAS No. : 1217720-20-1 Biological Activity：Ritonavir-d6 (ABT 538-d6) is the deuterium labeled Ritonavir. Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.61 μM[2]. Research Area：Infection […]

For research use only. We do not sell to patients. Aliskiren CAS No. : 173334-57-1 Biological Activity：Aliskiren is an orally active, highly potent and selective renin inhibitor, with IC50 of 1.5 nM. Aliskiren can be used for the research of hypertension, cardiovascular diseases and cancer cachexia[2][3]. Research Area：Cardiovascular Disease|Cancer Targets：Autophagy|Renin Related Screening Libraries:Drug Repurposing Compound […]

For research use only. We do not sell to patients. Tubulin polymerization-IN-14 CAS No. : 2417134-05-3 Biological Activity：Tubulin polymerization-IN-14 (Compound 20a) is a tubulin polymerization inhibitor with an IC50 of 3.15 μM. Tubulin polymerization-IN-14 shows potent anti-vascular and anticancer activities, induces cancer cell apoptosis. Research Area：Cancer Targets：Microtubule/Tubulin|Apoptosis Related Small Molecules:Physalin A;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;Tirbanibulin dihydrochloride;BJE6-106;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase […]

For research use only. We do not sell to patients. Efavirenz-d5 CAS No. : 1132642-95-5 Biological Activity：Efavirenz-d5 (DMP 266-d5) is the deuterium labeled Efavirenz. Efavirenz (DMP 266) is a potent inhibitor of the wild-type HIV-1 reverse transcriptase with a Ki of 2.93 nM and exhibits an IC95 of 1.5 nM for the inhibition of HIV-1 […]

For research use only. We do not sell to patients. TL02-59 CAS No. : 1315330-17-6 Biological Activity：TL02-59 is an orally active, selective Src-family kinase Fgr inhibitor with an IC50 of 0.03 nM. TL02-59 inhibits Lyn and Hck with IC50s of 0.1 nM and 160 nM, respectively. TL02-59 potently suppresses acute myelogenous leukemia (AML) cell growth. […]

For research use only. We do not sell to patients. BOLD-100 CAS No. : 783324-98-1 Biological Activity：BOLD-100 is a ruthenium-based anticancer agent. BOLD-100 also is an inhibitor of stress-induced GRP78 upregulation, disrupting endoplasmic reticulum (ER) homeostasis and inducing ER stress and unfolded protein response (UPR). BOLD-100 interferes with the complex interplay between ER-stress response, lysosome […]

For research use only. We do not sell to patients. CCT128930 CAS No. : 885499-61-6 Biological Activity：CCT128930 is a ATP-competitive and selective inhibitor of AKT (IC50=6 nM for AKT2). CCT128930 has 28-fold selectivity over the closely related PKA kinase (IC50=168 nM) through the targeting of Met282 of AKT (Met173 of PKA-AKT chimera), as well as […]

For research use only. We do not sell to patients. Pentagamavunon-1 CAS No. : 27060-70-4 Biological Activity：Pentagamavunon-1 (PGV-1), a Curcumin analog with oral activity, targets on several molecular mechanisms to induce apoptosis including inhibition of angiogenic factors cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF). PGV-1 inhibits NF-κB activation. Research Area：Cancer Targets：NF-κB|VEGFR|Apoptosis|COX Related Screening Libraries:Bioactive […]

For research use only. We do not sell to patients. STF-31 CAS No. : 724741-75-7 Biological Activity：STF-31 is a selective inhibitor of glucose transporter 1 (GLUT1), with an IC50 of 1 μM. STF-31 is also a NAMPT inhibitor. STF-31 inhibits glucose uptake in renal cell carcinoma (RCC) 4 cells[2]. Research Area：Cancer Targets：Autophagy|GLUT Related Screening Libraries:Bioactive […]