Tag: Inducer

For research use only. We do not sell to patients. Lomustine CAS No. : 13010-47-4 Biological Activity：Lomustine (CCNU; NSC 79037) is a DNA alkylating agent, with antitumor activity. Research Area：Cancer Targets：DNA Alkylator/Crosslinker|Autophagy|Apoptosis Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;Apoptosis Compound Library;Cell Cycle/DNA Damage Compound Library;FDA-Approved Drug […]

For research use only. We do not sell to patients. PROTAC-O4I2 Biological Activity：PROTAC-O4I2 is a PROTAC targets splicing factor 3B1 (SF3B1). PROTAC-O4I2 induces FLAG-SF3B1 degradation with an IC50 value of 0.244 μM in K562 cells. PROTAC-O4I2 also induces cellular apoptosis in K562 WT cells. Research Area：Cancer Targets：PROTACs|Apoptosis Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Anti-Cancer […]

For research use only. We do not sell to patients. Minnelide-d3 Biological Activity：Minnelide-d3 is the deuterium labeled Minnelide. Minnelide is a prodrug of triptolide that shows potent antitumor activity in a number of tumor types, particularly in pancreatic cancer. Minnelide promotes apoptosis. Research Area：Cancer Targets：Apoptosis Related Small Molecules:Physalin A;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;BJE6-106;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor 3;Xevinapant;Mangiferin;Cambinol;Antioxidant […]

For research use only. We do not sell to patients. Demethylzeylasteral CAS No. : 107316-88-1 Biological Activity：Demethylzeylasteral is a triterpene compound isolated from Tripterygium wilfordii Hook F, with anti-inflammatory, immunosuppressive and anti-tumor activities[2][3][4][5]. Demethylzeylasteral can significantly alleviates atherosclerosis (AS)[5]. Demethylzeylasteral inhibits triple-negative breast cancer invasion by blocking the canonical and non-canonical TGF-β signaling pathways[2]. Research […]

For research use only. We do not sell to patients. Acacetin CAS No. : 480-44-4 Biological Activity：Acacetin (5,7-Dihydroxy-4′-methoxyflavone) is an orally active flavonoid derived from Dendranthema morifolium. Acacetin docks in the ATP binding pocket of PI3Kγ. Acacetin causes cell cycle arrest and induces apoptosis and autophagy in cancer cells. Acacetin has potent anti-cancer and anti-inflammatory […]

For research use only. We do not sell to patients. ZZW-115 hydrochloride CAS No. : 10122-45-9 Biological Activity：ZZW-115 hydrochloride is a potent NUPR1 inhibitor, with a Kd of 2.1 μM. ZZW-115 hydrochloride induces tumor cell death by necroptosis and apoptosis. Anticancer activity[2]. Research Area：Cancer Targets：Apoptosis Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Anti-Cancer Compound Library;Targeted […]

For research use only. We do not sell to patients. 3′-Hydroxypterostilbene CAS No. : 475231-21-1 Biological Activity：3′-Hydroxypterostilbene is a Pterostilbene (HY-N0828) analogue. 3′-Hydroxypterostilbene inhibits the growth of COLO 205, HCT-116 and HT-29 cells with IC50s of 9.0, 40.2 and 70.9 µM, respectively. 3′-Hydroxypterostilbene significantly down-regulates PI3K/Akt and MAPKs signaling pathways and effectively inhibits the growth […]

For research use only. We do not sell to patients. Antitumor agent-79 CAS No. : 2750233-50-0 Biological Activity：Antitumor agent-79 shows good antiproliferative activities against hepatocellular carcinoma and breast cancer cells with IC50 values of 0.7-7.9 μM. Antitumor agent-79 induces cancer cells apoptosis and shows in vivo antitumor effects. Antitumor agent-79 can be used for the […]

For research use only. We do not sell to patients. Anticancer agent 81 Biological Activity：Anticancer agent 81 (Compound 37b3) is an anticancer agent and can induce tumor cell cycle arrest and apoptosis. Anticancer agent 81 can be used as a payload to conjugate with Trastuzumab (HY-P9907) to obtain the antibody–drug conjugate (ADC) T-PBA. T-PBA maintained […]

For research use only. We do not sell to patients. Melflufen hydrochloride CAS No. : 380449-54-7 Biological Activity：Melflufen (Melphalan flufenamide) hydrochloride, a dipeptide prodrug of Melphalan, is an alkylating agent. Melflufen hydrochloride shows antitumor activity against multiple myeloma (MM) cells and inhibits angiogenesis. Melflufen hydrochloride induces irreversible DNA damage and cytotoxicity in MM cells[2][3]. Research […]