Tag: Antagonist|Inhibitor

For research use only. We do not sell to patients. Aplaviroc hydrochloride CAS No. : 461023-63-2 Biological Activity：Aplaviroc (AK 602) hydrochloride, a SDP derivative, is a CCR5 antagonist, with IC50s of 0.1-0.4 nM for HIV-1Ba-L, HIV-1JRFL and HIV-1MOKW. Research Area：Infection Targets：HIV|CCR Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus; Related […]

For research use only. We do not sell to patients. Pimozide CAS No. : 2062-78-4 Biological Activity：Pimozide is a dopamine receptor antagonist, with Kis of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM; Pimozide also inhibits […]

For research use only. We do not sell to patients. (Z)-Chlorprothixene-d6 hydrochloride Biological Activity：(Z)-Chlorprothixene-d6 hydrochloride is the deuterium labeled Chlorprothixene. Chlorprothixene is a dopamine and histamine receptors antagonist with Kis of 18 nM, 2.96 nM, 4.56 nM, 9 nM and 3.75 nM for hD1, hD2, hD3, hD5 and hH1 receptors, respectively. Antipsychotic activity. Research Area：Neurological […]

For research use only. We do not sell to patients. Dexanabinol CAS No. : 112924-45-5 Biological Activity：Dexanabinol (HU-211) is a synthetic cannabinoid derivative (non-psychoactive cannabinoid). Dexanabinol effectively inhibits the production of TNF-α and NO and has NMDA antagonistic activity. Dexanabinol is also a neuroprotectant that effectively scavenges peroxygen free radicals and protects neurons from the […]

For research use only. We do not sell to patients. Norleual CAS No. : 334994-34-2 Biological Activity：Norleual, an angiotensin (Ang) IV analog, is a hepatocyte growth factor (HGF)/c-Met inhibitor with an IC50 of 3 pM. Norleual is an AT4 receptor antagonist and exhibits potent antiangiogenic activities. Research Area：Metabolic Disease|Neurological Disease Targets：Angiotensin Receptor|c-Met/HGFR Related Small Molecules:AMG-208;D6808;MET […]

For research use only. We do not sell to patients. Pimozide-d4 CAS No. : 1803193-57-8 Biological Activity：Pimozide D4 (R6238 D4) is a deuterium labeled Pimozide. Pimozide is a dopamine receptor antagonist, with Kis of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, […]

For research use only. We do not sell to patients. 6-Mercaptopurine CAS No. : 50-44-2 Biological Activity：6-Mercaptopurine is a purine analogue which acts as an antagonist of the endogenous purines and has been widely used as antileukemic agent and immunosuppressive drug. Research Area：Cancer Targets：Nucleoside Antimetabolite/Analog|Autophagy|Endogenous Metabolite Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library […]

For research use only. We do not sell to patients. Rimonabant-d10 CAS No. : 929221-88-5 Biological Activity：Rimonabant-d10 is deuterium labeled Rimonabant. Rimonabant (SR141716) is a highly potent, brain penetrated and selective central cannabinoid receptor (CB1) antagonist with a Ki of 1.8 nM. Rimonabant (SR141716) also inhibits Mycobacterial membrane protein Large 3 (MMPL3). Research Area：Infection|Metabolic Disease|Cancer […]

For research use only. We do not sell to patients. Cenicriviroc Mesylate CAS No. : 497223-28-6 Biological Activity：Cenicriviroc Mesylate (TAK-652 Mesylate) is a dual CCR2/CCR5 antagonist, also inhibits both HIV-1 and HIV-2, and displays potent anti-inflammatory and antiinfective activity. Research Area：Infection|Inflammation/Immunology|Endocrinology Targets：HIV|CCR Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;Anti-Infection […]

For research use only. We do not sell to patients. TD-0212 TFA CAS No. : 1073549-11-7 Biological Activity：TD-0212 TFA is an orally active dual pharmacology angiotensin II type 1 receptor (AT1) antagonist and neprilysin (NEP) inhibitor, with a pKi of 8.9 for AT1 and a pIC50 of 9.2 for NEP. Research Area：Inflammation/Immunology Targets：Angiotensin Receptor|Neprilysin Related […]