Tag: Antagonist|Inhibitor

For research use only. We do not sell to patients. Propafenone CAS No. : 54063-53-5 Biological Activity：Propafenone (SA-79), a sodium-channel blocker, acts an antiarrhythmic agent. Propafenone also has high affinity for the β receptor (IC50=32 nM). Propafenone blocks the transient outward current (Ito) and the sustained delayed rectifier K current (Isus) with IC50 values of […]

For research use only. We do not sell to patients. MCHR1 antagonist 2 CAS No. : 863115-70-2 Biological Activity：MCHR1 antagonist 2 is an antagonist of melanin concentrating hormone receptor 1, with an IC50 of 65 nM; MCHR1 antagonist 2 also inhibits hERG, with an IC50 of 4.0 nM in IMR-32 cells. Research Area：Metabolic Disease|Endocrinology Targets：MCHR1 […]

For research use only. We do not sell to patients. Atraric acid CAS No. : 4707-47-5 Biological Activity：Atraric acid (Methyl atrarate) is a specific androgen receptor (AR) antagonist with anti-inflammatory and anticancer effects. Atraric acid represses the expression of the endogenous prostate specific antigen gene in both LNCaP and C4-2 cells. Atraric acid can also […]

For research use only. We do not sell to patients. CGS 15943 CAS No. : 104615-18-1 Biological Activity：CGS 15943 is an orally bioavailable non-xanthine Adenosine Receptor antagonist. Its Ki for human A1, A2A, A2B, and A3 Adenosine Receptors are 3.5, 4.2, 16, and 50 nM in transfected CHO cells, respectively. [2]. Research Area：Cancer|Inflammation/Immunology Targets：Adenosine Receptor|PI3K […]

For research use only. We do not sell to patients. Eplivanserin (mixture) CAS No. : 130581-13-4 Biological Activity：Eplivanserin mixture (SR-46349 mixture) is a selective serotonin reuptake inhibitor and a 5-HT2A receptor antagonist, extracted from patent WO 2005/002578 A1. Research Area：Neurological Disease Targets：5-HT Receptor|Serotonin Transporter Related Screening Libraries:Bioactive Compound Library Plus; Related Small Molecules:F 13714;Mosapride-d5;Nuciferine;Renzapride;LY 344864 […]

For research use only. We do not sell to patients. Aplaviroc CAS No. : 461443-59-4 Biological Activity：Aplaviroc (AK 602), a SDP derivative, is a CCR5 antagonist, with IC50s of 0.1-0.4 nM for HIV-1Ba-L, HIV-1JRFL and HIV-1MOKW. Research Area：Infection|Endocrinology Targets：HIV|CCR Related Small Molecules:HIV-1 TAT (48-60);Seletracetam lithium;HIV-IN-2;Triptonine B;LMD-009;FC131;Peritassine A;PF-04634817 succinate;Flavopiridol;TAT (48-57);FGI-106 tetrahydrochloride;(Z)-9-Propenyladenine;Apabetalone;Decanoyl-RVKR-CMK TFA;ONX-0914 TFA;Apelin-36(rat, mouse);Ulonivirine;Islatravir Trending products：Recombinant […]

For research use only. We do not sell to patients. Azelastine CAS No. : 58581-89-8 Biological Activity：Azelastine, an antihistamine, is a potent and selective histamine 1 (H1) antagonist. Azelastine can be used for the research of allergic rhinitis, asthma, diabetic hyperlipidemic and SARS-CoV-2[2][3][4]. Research Area：Infection|Endocrinology|Metabolic Disease|Inflammation/Immunology Targets：Histamine Receptor|SARS-CoV Related Small Molecules:Tripelennamine;SARS-CoV-2-IN-33;Brompheniramine-d6 maleate;GRL-0496;Samelisant;Chlorphenoxamine;Grazoprevir potassium salt;H3 receptor-MO-1;SARS-CoV-2-IN-19;Diphenhydramine;Molnupiravir;SARS-CoV-2 […]

For research use only. We do not sell to patients. Flavoxate hydrochloride CAS No. : 3717-88-2 Biological Activity：Flavoxate hydrochloride is a potent and competitive phosphodiesterase (PDE) inhibitor. Flavoxate hydrochloride is an antispasmodic agent and muscarinic mAChR antagonist. Flavoxate hydrochloride shows moderate calcium antagonistic activity and local anesthetic effect. Flavoxate hydrochloride can be used for the […]

For research use only. We do not sell to patients. Glaucine-d6 Biological Activity：Glaucine-d6 (O,O-Dimethylisoboldine-d6) is the deuterium labeled Glaucine. Glaucine (O,O-Dimethylisoboldine) is an alkaloid isolated from Glaucium flavum Crantz with antitussive, bronchodilation and anti-inflammatory properties. Glaucine is a selective and orally active phosphodiesterase 4 (PDE4) inhibitor with Kis of 3.4 µM in human bronchus and […]

For research use only. We do not sell to patients. Chlorprothixene-d6 hydrochloride Biological Activity：Chlorprothixene-d6 hydrochloride is the deuterium labeled Chlorprothixene hydrochloride. Chlorprothixene hydrochloride is a dopamine and histamine receptors antagonist with Kis of 18 nM, 2.96 nM, 4.56 nM, 9 nM and 3.75 nM for hD1, hD2, hD3, hD5 and hH1 receptors, respectively. Antipsychotic activity. […]