Tag: Antagonist

For research use only. We do not sell to patients. AHR antagonist 5 CAS No. : 2247953-39-3 Biological Activity：AHR antagonist 5, a potent and orally active aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018195397, example 39, has an IC50 of < 0.5 µΜ. AHR antagonist 5 significantly inhibits tumor growth combined with checkpoint inhibitor […]

For research use only. We do not sell to patients. Vidupiprant CAS No. : 1169483-24-2 Biological Activity：Vidupiprant (AMG 853) is a phenylacetic acid derivative. Vidupiprant is a potent and orally active CRTH2 (DP2) and prostanoid D receptor (DP or DP1) dual antagonist with IC50s of 3 nM and 4 nM in buffer, and 8 nM […]

For research use only. We do not sell to patients. JDTic dihydrochloride CAS No. : 785835-79-2 Biological Activity：JDTic (dihydrochloride) is a potent antagonist of kappa-opioid receptors (KOR), blocking the κ-agonist U50, 488-induced antinociception. Research Area：Neurological Disease Targets：Opioid Receptor Related Screening Libraries:Clinical Compound Library Plus;Bioactive Compound Library Plus;GPCR/G Protein Compound Library;Neuronal Signaling Compound Library;Clinical Compound Library;Neurotransmitter […]

For research use only. We do not sell to patients. R-BC154 acetate Biological Activity：R-BC154 acetate is a selective fluorescent α9β1 integrin antagonist. R-BC154 acetate acts as a useful high affinity, activation dependent integrin probe, which can be used to investigate α9β1 and α4β1 integrin binding activity. Research Area：Cancer|Inflammation/Immunology Targets：Integrin Related Small Molecules:GRGDSPK;Integrin Binding Peptide;Cyclo(Arg-Gly-Asp-D-Phe-Cys);Zaurategrast ethyl […]

For research use only. We do not sell to patients. Tropatepine CAS No. : 27574-24-9 Biological Activity：Tropatepine is an orally active, anticholinergic muscarinic antagonist and can be used as an antiparkinsonian agent. Tropatepine is used to combat against extrapyramidal syndrome induced by neuroleptic drugs[2]. Research Area：Neurological Disease Targets：Others Related Small Molecules:Immune initiator-1;Obiltoxaximab;DIBAC-GGFG-NH2CH2-Dxd;Cyanine5.5 maleimide chloride;Cymarin;Z-Glycine;2-Deoxy-2-fluoro-D-glucose-13C,d7;Water-18O;Fmoc-N-Me-D-Ala-OH;3,5-Diiodo-L-tyrosine;N3-Pen-Dde;Zimeldine-d6;Ornidazole diol;Nylidrin […]

For research use only. We do not sell to patients. ERRα antagonist-2 Biological Activity：ERRα antagonist-2 (Compound 11) is a potential ERRα (estrogen related receptor α) inverse agonist with an IC50 of 0.80 μM. ERRα antagonist-2 suppresses the migration and invasion of the ER-negative MDA-MB-231 cell line. ERRα antagonist-2 inhibits breast cancer growth in vivo. Research Area：Cancer […]

For research use only. We do not sell to patients. ATN-161 trifluoroacetate salt CAS No. : 904763-27-5 Biological Activity：ATN-161 trifluoroacetate salt is a novel integrin α5β1 antagonist, which inhibits angiogenesis and growth of liver metastases in a murine model. Research Area：Cancer Targets：Integrin Related Screening Libraries:Covalent Screening Library Plus;Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive […]

For research use only. We do not sell to patients. Rp-cAMPS CAS No. : 73208-40-9 Biological Activity：Rp-cAMPS, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (Kis of 12.5 µM and 4.5 µM, respectively) antagonist. Rp-cAMPS is resistant to hydrolysis by phosphodiesterases[2][3][4][5][6]. Research Area：Neurological Disease Targets：PKA Related Small Molecules:PKI […]

For research use only. We do not sell to patients. BQ-123 TFA Biological Activity：BQ-123 TFA is a potent and selective endothelin A (ETA) receptor antagonist with an IC50 of 7.3 nM and a Ki of 25 nM. BQ-123 TFA inhibits endothelin-1-mediated proliferation of human pulmonary artery smooth muscle cells and lowers blood pressure in different […]

For research use only. We do not sell to patients. GW627368 CAS No. : 439288-66-1 Biological Activity：GW627368 (GW627368X) is a novel, potent and selective competitive antagonist of prostanoid EP4 receptor with additional human TP receptor affinity, with pKi values of 7.0 and 6.8 for human prostanoid EP4 and TP receptors respectively. Research Area：Inflammation/Immunology|Endocrinology|Cancer Targets：Prostaglandin Receptor […]