Tag: Antagonist

For research use only. We do not sell to patients. CU-CPT9b CAS No. : 2162962-69-6 Biological Activity：CU-CPT9b is a specific TLR8 antagonist, with an IC50 of 0.7 nM. CU-CPT9b shows high binding affinity towards TLR8 with a Kd of 21 nM. Research Area：Inflammation/Immunology Targets：Toll-like Receptor (TLR) Related Screening Libraries:Bioactive Compound Library Plus;Immunology/Inflammation Compound Library;Small Molecule […]

For research use only. We do not sell to patients. Ziprasidone D8 CAS No. : 1126745-58-1 Biological Activity：Ziprasidone D8 is deuterium labeled Ziprasidone, which is a combined 5-HT (serotonin) and dopamine receptor antagonist which exhibits potent effects of antipsychotic activity. Research Area：Neurological Disease Targets：Dopamine Receptor|5-HT Receptor Related Small Molecules:F 13714;Alizapride hydrochloride;Thioproperazine;Mosapride-d5;Bromopride-d3;Nuciferine;Glaucine;Renzapride;SB-277011 dihydrochloride;LY 344864 racemate;Harmine hydrochloride;MIF-1 […]

For research use only. We do not sell to patients. Icatibant CAS No. : 130308-48-4 Biological Activity：Icatibant (HOE-140) is a potent and specific peptide antagonist of bradykinin B2 receptor with IC50 and Ki of 1.07 nM and 0.798 nM respectively[2][3]. Research Area：Endocrinology Targets：Bradykinin Receptor Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;Bioactive Compound […]

For research use only. We do not sell to patients. Diphenylpyraline CAS No. : 147-20-6 Biological Activity：Diphenylpyraline is a potent histamine H1 receptor antagonist. Diphenylpyraline acts as an orally active antihistamine agent with antimuscarinic and antiallergic effects. Diphenylpyraline can be used for the research of allergic diseases, including rhinitis and hay fever, and pruritic skin disorders et.al. […]

For research use only. We do not sell to patients. CGP52432 CAS No. : 139667-74-6 Biological Activity：CGP52432 is a GABAB receptor antagonist, with an IC50 of 85 nM. Research Area：Neurological Disease Targets：GABA Receptor Related Screening Libraries:Bioactive Compound Library Plus;Membrane Transporter/Ion Channel Compound Library;Neuronal Signaling Compound Library;Neurotransmitter Receptor Compound Library;Anti-Alzheimer’s Disease Compound Library;Anti-Parkinson’s Disease Compound Library;Neurodegenerative […]

For research use only. We do not sell to patients. MPEP CAS No. : 96206-92-7 Biological Activity：MPEP is a potent, selective, noncompetitive, orally active and systemically active mGlu5 receptor antagonist, with an IC50 of 36 nM for completely inhibiting quisqualate-stimulated phosphoinositide (PI) hydrolysis. MPEP has anxiolytic-or antidepressant-like effects[2]. Research Area：Neurological Disease Targets：mGluR Related Small Molecules:LY3020371 […]

For research use only. We do not sell to patients. Ibipinabant CAS No. : 464213-10-3 Biological Activity：Ibipinabant (SLV319) is a potent, selective and orally active antagonist of cannabinoid CB1 receptor, with a Ki of 7.8 nM. Ibipinabant shows more than 1000-fold selectivity for CB1 over CB2 (Ki=7943 nM). Ibipinabant can be used for the research […]

For research use only. We do not sell to patients. DL-AP4 CAS No. : 6323-99-5 Biological Activity：DL-AP4 (2-Amino-4-phosphonobutyric acid) is a glutamate antagonist. DL-AP4 behaves as a competitive inhibitor of glutamate binding with an apparent Kd of 66 μM. DL-AP4 can be used for the research of central nervous system and visual system[2][3]. Research Area：Metabolic […]

For research use only. We do not sell to patients. TCS 2314 CAS No. : 317353-73-4 Biological Activity：TCS 2314 (compound 3) is orally active and selective very late antigen-4 (VLA-4, α4β1, CD49d/CD29) antagonist with an IC50 of 4.4 nM. Research Area：Inflammation/Immunology Targets：Integrin Related Small Molecules:GRGDSPK;Integrin Binding Peptide;Cyclo(Arg-Gly-Asp-D-Phe-Cys);Zaurategrast ethyl ester sulfate;HSDVHK-NH2;Lifitegrast sodium;TC-I 15;α2β1 Integrin Ligand Peptide;Integrin […]

For research use only. We do not sell to patients. Estriol CAS No. : 50-27-1 Biological Activity：Estriol is an antagonist of the G-protein coupled estrogen receptor in estrogen receptor-negative breast cancer cells. Target: Estrogen Receptor/ERR A recent study shows that estrogen (estrone, estradiol, and estriol) inhibits Alzheimer’s disease-associated low-order Aβ oligomer formation, and among them, […]