Tag: Antagonist

For research use only. We do not sell to patients. Terazosin dimer impurity dihydrochloride CAS No. : 1486464-41-8 Biological Activity：Terazosin dimer impurity dihydrochloride, a dimer of Terazosin, is an impurity of Terazosin. Terazosin is a quinazoline derivative and a competitive and orally active α1-adrenoceptor antagonist. Research Area：Others Targets：Adrenergic Receptor Related Small Molecules:Todralazine;ARC 239 dihydrochloride;Yohimbine;Glaucine;Salbutamol;BI-167107;Talibegron hydrochloride;Arotinolol;SR59230A;Higenamine […]

For research use only. We do not sell to patients. ESI-08 CAS No. : 301177-43-5 Biological Activity：ESI-08 is a potent and selective EPAC antagonist, which can completely inhibit both EPAC1 and EPAC2 (IC50 of 8.4 μM) activity. ESI-08 selectively blocks cAMP-induced EPAC activation, but does not inhibit cAMP-mediated PKA activation. Research Area：Cancer|Metabolic Disease|Cardiovascular Disease Targets：Ras […]

For research use only. We do not sell to patients. Procion Blue HB CAS No. : 12236-82-7 Biological Activity：Procion Blue HB (Reactive Blue 2) is a purinergic antagonist. Research Area：Neurological Disease|Cardiovascular Disease Targets：Others Related Small Molecules:Immune initiator-1;Obiltoxaximab;DIBAC-GGFG-NH2CH2-Dxd;Cyanine5.5 maleimide chloride;Cymarin;Z-Glycine;2-Deoxy-2-fluoro-D-glucose-13C,d7;Water-18O;Fmoc-N-Me-D-Ala-OH;3,5-Diiodo-L-tyrosine;N3-Pen-Dde;Zimeldine-d6;Ornidazole diol;Nylidrin hydrochloride;PFI-653;N-Arachidonoyl Taurine-d4;OVA Peptide (323-339);((3-Fluorophenyl)sulfonyl)glycine;7ß-Hydroxycholesterol-d7;MALAT1-IN-1;Sibiricose A1;Mefruside-d3;Ethacrynic acid mercapturate-d3;FLAG peptide;Neocurdione Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  […]

For research use only. We do not sell to patients. GR 94800 CAS No. : 141636-65-9 Biological Activity：GR 94800 is a potent and selective NK2 receptor peptide antagonist, with pKB values of 9.6, 6.4 and 6.0 for NK2, NK1 and NK3 receptors, respectively[2]. Research Area：Neurological Disease Targets：Neurokinin Receptor Related Small Molecules:(β-Ala8)-Neurokinin A (4-10);Talnetant hydrochloride;Pavinetant;MEN11467;(D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance P;Vapreotide […]

For research use only. We do not sell to patients. Sonidegib diphosphate CAS No. : 1218778-77-8 Biological Activity：Sonidegib diphosphate (Erismodegib diphosphate) is a potent and selective Smo antagonist with IC50 of 1.3 nM and 2.5 nM for mouse and human Smo in binding assay, respectively. Research Area：Cancer Targets：Smo Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved […]

For research use only. We do not sell to patients. UBP301 CAS No. : 569371-10-4 Biological Activity：UBP301 is a potent and selective antagonist of kainate receptor with IC50 and KD of 164 μM and 5.94 μM, respectively. UBP301 has ∼30-fold selectivity of kainate receptor over AMPA receptor. UBP301 is the derivative of willardiine. Research Area：Neurological […]

For research use only. We do not sell to patients. Zotepine CAS No. : 26615-21-4 Biological Activity：Zotepine, an antipsychotic agent, is a potent antagonist of 5-HT2A, 5-HT2C, Histamine H1, α1-adrenergic and Dopamine D2 receptors, with Kds of 2.6 nM, 3.2 nM, 3.3 nM, 7.3 nM and 8 nM, respectively. Zotepine exhibits antidepressive and anxiolytic effects […]

For research use only. We do not sell to patients. Phenprocoumon CAS No. : 435-97-2 Biological Activity：Phenprocoumon is a coumarin derivative that acts as a long acting oral anticoagulant and an antagonist of vitamin K. Research Area：Others Targets：Others Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;FDA-Approved Drug […]

For research use only. We do not sell to patients. Huwentoxin XVI CAS No. : 1600543-88-1 Biological Activity：Huwentoxin XVI, an analgesic, is a highly reversible and selective mammalian N-type calcium channel (IC50 of ~60 nM) antagonist from Chinese tarantula Ornithoctonus huwena. Huwentoxin XVI has no effect on voltagegated T-type calcium channels, potassium channels or sodium […]

For research use only. We do not sell to patients. JKC363 CAS No. : 436083-30-6 Biological Activity：JKC363, a selective melanocortin MC4 receptor antagonist, has a 90-fold higher affinity at the MC4 receptor (IC50=0.5 nM) than at the MC3 receptor (44.9 nM). JKC-363 blocks the stimulatory effect of α-MSH on TRH release. Anti-hyperalgesic effect[2]. Research Area：Neurological […]