Tag: Antagonist

For research use only. We do not sell to patients. BIBO3304 TFA CAS No. : 191868-14-1 Biological Activity：BIBO3304 TFA is a potent, orally active, and selective neuropeptide Y (NPY) Y1 receptor antagonist, with subnanomolar affinity for both the human and the rat Y1 receptor (IC50=0.38 and 0.72 nM, respectively). Research Area：Metabolic Disease Targets：Neuropeptide Y Receptor […]

For research use only. We do not sell to patients. Lifitegrast CAS No. : 1025967-78-5 Biological Activity：Lifitegrast (SAR 1118) is a potent integrin antagonist. Lifitegrast blocks the binding of intercellular adhesion molecule 1 (ICAM-1) to lymphocyte function-associated antigen 1 (LFA-1), interrupting the T cell-mediated inflammatory cycle. Lifitegrast inhibits Jurkat T cell attachment to ICAM-1 with […]

For research use only. We do not sell to patients. E4CPG CAS No. : 170846-89-6 Biological Activity：E4CPG ((RS)-ECPG) is a Group I/Group II metabotropic glutamate receptor (mGluR) antagonist. E4CPG can inhibit the paired-pulse ratio of monosynaptic inhibitory postsynaptic currents (IPSC) potentiation[2]. Research Area：Neurological Disease Targets：mGluR Related Screening Libraries:Bioactive Compound Library Plus; Related Small Molecules:LY3020371 hydrochloride;ZJ43;FPTQ;(S)-MCPG;mGluR2 […]

For research use only. We do not sell to patients. RC-3095 TFA CAS No. : 1217463-61-0 Biological Activity：RC-3095 TFA is a selective bombesin/gastrin releasing peptide receptor (GRPR) antagonist. RC-3095 TFA exerts protective effects by reducing gastric oxidative injury in the arthritic mice[2]. Research Area：Inflammation/Immunology Targets：Bombesin Receptor Related Screening Libraries:Bioactive Compound Library Plus;Peptide Library; Related Small […]

For research use only. We do not sell to patients. Estrogen receptor antagonist 4 CAS No. : 2730011-45-5 Biological Activity：Estrogen receptor antagonist 4 is a potent antagonist of estrogen receptor (ER). The estrogen signaling system plays an important role in regulating cell growth, differentiation and apoptosis. Estrogen receptor antagonist 4 has the potential for the […]

For research use only. We do not sell to patients. Netupitant CAS No. : 290297-26-6 Biological Activity：Netupitant (CID-6451149) is a highly potent, selective and orally active neurokinin-1 (NK1) receptor antagonist with a Ki of 0.95 nM for hNK1 in CHO cells. Netupitant has antiemetic affect[2][3]. Research Area：Neurological Disease|Endocrinology Targets：Neurokinin Receptor Related Screening Libraries:Drug Repurposing Compound […]

For research use only. We do not sell to patients. Setipiprant CAS No. : 866460-33-5 Biological Activity：Setipiprant (ACT-129968) is an orally active and selective CRTH2 antagonist. Setipiprant interacts with hCRTH2 receptor with an IC50 value of 6 nM. Setipiprant inhibits prostanoid receptors hDP1 and hEP2 with IC50 values of 1290 and 2600 nM, respectively. Setipiprant […]

For research use only. We do not sell to patients. Amlodipine maleate CAS No. : 88150-47-4 Biological Activity：Amlodipine maleate is a dihydropyridine calcium channel blocker, acts as an orally active antianginal agent. Amlodipine maleate blocks the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine maleate can be used for the research […]

For research use only. We do not sell to patients. NH-3 CAS No. : 447415-26-1 Biological Activity：NH-3 is an orally active, reversible thyroid hormone receptor (THR) antagonist with an IC50 of 55 nM. NH-3, a derivative of the selective thyromi-metic GC-1, inhibits binding of thyroid hormones to their receptor and that inhibits cofactor recruitment[2][3]. Research […]

For research use only. We do not sell to patients. Carebastine-d5 CAS No. : 1189661-02-6 Biological Activity：Carebastine-d5 is the deuterium labeled Carebastine. Carebastine is the active metabolite of Ebastine. Carebastine is a histamine H1 receptor antagonist. Carebastine inhibits VEGF-induced HUVEC and HPAEC proliferation, migration and angiogenesis in a dose-dependent manner. Carebastine suppresses the expression of […]