Tag: Antagonist

For research use only. We do not sell to patients. CCR4-351 CAS No. : 2174938-70-4 Biological Activity：CCR4-351 is an orally active, potent and selective CCR4 antagonist. CCR4-351, featuring a novel piperidinyl-azetidine motif, has IC50s of 22 nM and 50 nM in the calcium flux and CTX assay. CCR4-351 has antitumor activity. Research Area：Cancer Targets：CCR Related […]

For research use only. We do not sell to patients. SOR-C13 CAS No. : 1187852-48-7 Biological Activity：SOR-C13, a carboxy-terminal truncated peptide, is a high-affinity TRPV6 antagonist with an IC50 value of 14 nM. TRPV6 is a non-voltage gated calcium channel that is associated with malignancy and poor prognosis in breast cancer. SOR-C13 has anticancer activity. […]

For research use only. We do not sell to patients. (±)-Darifenacin-d4 CAS No. : 1189701-43-6 Biological Activity：(±)-Darifenacin-d4 is deuterium labeled (±)-Darifenacin. (±)-Darifenacin is the racemate of Darifenacin. Darifenacin is a selective M3 muscarinic receptor antagonist. Research Area：Cancer|Neurological Disease Targets：mAChR Related Small Molecules:VU0357017 hydrochloride;TBPB;Imidafenacin;Sabcomeline;MK-6884;Brompheniramine-d6 maleate;Navafenterol saccharinate;DREADD agonist 21;Cyclobuxine D;Brompheniramine maleate;Dexetimide;Anisodamine hydrobromide;Anisotropine bromide;PD 102807;Nebracetam hydrochloride;Muscarine-d9 iodide;Mazaticol;VU0455691;Arborine;Oxitropium Bromide;Propiverine […]

For research use only. We do not sell to patients. Atogepant CAS No. : 1374248-81-3 Biological Activity：Atogepant (MK-8031) is an orally active and selective calcitonin gene–related peptide receptor (CGRP) antagonist. Atogepant can be used for researching migraine. Research Area：Neurological Disease Targets：CGRP Receptor Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;Bioactive Compound Library Plus; […]

For research use only. We do not sell to patients. Deucrictibant CAS No. : 2340111-58-0 Biological Activity：Deucrictibant is a potent bradykinin receptor antagonist. Bradykinin receptors are cell surface, G-protein coupled receptors of the seven-transmembrane domained family. Research Area：Others Targets：Bradykinin Receptor Related Small Molecules:Icatibant acetate;Retrobradykinin;Bombinakinin M;[Tyr8] Bradykinin;Bradykinin (2-9);Fasitibant chloride;WIN 64338 hydrochloride;ELN-441958;Bradykinin (1-7);Lys-[Hyp3]-Bradykinin;Bradykinin (1-6);[Hyp3]-Bradykinin;[Des-Arg9]-Bradykinin acetate;Lys-[Des-Arg9]Bradykinin TFA;Lobradimil;Bradykinin;Bradykinin (1-5);FR167344 […]

For research use only. We do not sell to patients. (S)-(-)-Propranolol-d7 hydrochloride CAS No. : 1346617-12-6 Biological Activity：(S)-(-)-Propranolol-d7 hydrochloride is the deuterium labeled (S)-(-)-Propranolol hydrochloride. (S)-(-)-Propranolol hydrochloride is a β-adrenergic receptor antagonist with log Kd values of -8.16, -9.08, and -6.93 for β1, β2, and β3, respectively. (S)-(-)-Propranolol hydrochloride the active enantiomer of propranolol and can […]

For research use only. We do not sell to patients. Tecarfarin CAS No. : 867257-26-9 Biological Activity：Tecarfarin (ATI-5923) is an orally active and non-competitive vitamin K epoxide reductase (VKOR) antagonist, and impairs the activation of the vitamin K-dependent clotting factors II, VII, IX and X. Tecarfarin has the antithrombotic activity [2]. Research Area：Cardiovascular Disease Targets：Others […]

For research use only. We do not sell to patients. MK-2894 sodium salt CAS No. : 1006036-88-9 Biological Activity：MK-2894 sodium salt is a potent, selective, orally active and high affinity (Ki=0.56 nM) full antagonist against E prostanoid receptor 4 (EP4 receptor) (IC50=2.5 nM). MK-2894 sodium salt possesses potent anti-inflammatory activity in animal models of pain/inflammation […]

For research use only. We do not sell to patients. Otenabant CAS No. : 686344-29-6 Biological Activity：Otenabant is a potent and selective cannabinoid receptor CB1 antagonist with Ki of 0.7 nM, exhibits 10,000-fold greater selectivity against human CB2 receptor. Research Area：Metabolic Disease Targets：Cannabinoid Receptor Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound […]

For research use only. We do not sell to patients. L-365260 hemihydrate Biological Activity：L-365260 hemihydrate is an orally active and selective antagonist of non-peptide gastrin and brain cholecystokinin receptor (CCK-B), with Kis of 1.9 nM and 2.0 nM, respectively. L-365260 hemihydrate interacts in a stereoselective and competitive manner with guinea pig stomach gastrin and brain […]