Tag: Antagonist

For research use only. We do not sell to patients. (D-Pro2,D-Trp6,8,Nle10)-Neurokinin B CAS No. : 109212-72-8 Biological Activity：(D-Pro2,D-Trp6,8,Nle10)-Neurokinin B is a competitive antagonist of Neurokinin B (Neurokinin Receptor) with a pA2 of 5.5. (D-Pro2,D-Trp6,8,Nle10)-Neurokinin B shows no influence on Substance P or Neurokinin A. Research Area：Neurological Disease Targets：Neurokinin Receptor Related Small Molecules:(β-Ala8)-Neurokinin A (4-10);Talnetant hydrochloride;Pavinetant;MEN11467;(D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance […]

For research use only. We do not sell to patients. ICI 118,551 hydrochloride CAS No. : 72795-01-8 Biological Activity：ICI 118,551 (hydrochloride) is a highly selective β2 adrenergic receptor antagonist, with Kis of 0.7, 49.5 and 611 nM for β2, β1 and β3 receptors, respectively. Research Area：Neurological Disease|Endocrinology Targets：Adrenergic Receptor Related Screening Libraries:Bioactive Compound Library Plus;GPCR/G […]

For research use only. We do not sell to patients. Ligustroflavone CAS No. : 260413-62-5 Biological Activity：Ligustroflavone, extracted from Ligustrum lucidum, is a potential candidate as calcium-sensing receptor (CaSR) antagonist. Ligustroflavone exhibits protective effects against diabetic osteoporosis in mice. Research Area：Metabolic Disease Targets：CaSR Related Screening Libraries:Natural Product Library Plus;Bioactive Compound Library Plus;GPCR/G Protein Compound Library;Natural […]

For research use only. We do not sell to patients. α-Conotoxin PnIA TFA Biological Activity：α-Conotoxin PnIA TFA, a potent and selective antagonist of the mammalian α7 nAChR, has the potential for the research of neurological conditions such as neuropathic pain and Alzheimer’s disease. Research Area：Neurological Disease Targets：nAChR Related Screening Libraries:Bioactive Compound Library Plus;Peptide Library; Related […]

For research use only. We do not sell to patients. GSK598809 CAS No. : 863680-45-9 Biological Activity：GSK598809 is a potent and selective dopamine D3 Receptor (DRD3) antagonist, with a pKi of 8.9. Research Area：Neurological Disease Targets：Dopamine Receptor Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;GPCR/G Protein Compound Library;Neuronal Signaling Compound […]

For research use only. We do not sell to patients. SB-203186 hydrochloride CAS No. : 207572-69-8 Biological Activity：SB-203186 hydrochloride is a potent, selective and competitive 5-HT4 antagonist. SB-203186 hydrochloride antagonizes the 5-HT4 receptor-mediated relaxations of the carbachol-contracted rat isolated oesophagus against 5-HT with pKB values of 10.9 (rat oesophagus), 9.5 (guinea-pig ileum), and 9.0 (human […]

For research use only. We do not sell to patients. Nuvenzepine CAS No. : 96487-37-5 Biological Activity：Nuvenzepine is an mAChR antagonist, has the potential for gastrospasm treatment. Research Area：Cardiovascular Disease Targets：mAChR Related Small Molecules:VU0357017 hydrochloride;TBPB;Imidafenacin;Sabcomeline;MK-6884;Brompheniramine-d6 maleate;Navafenterol saccharinate;DREADD agonist 21;Cyclobuxine D;Brompheniramine maleate;Dexetimide;Anisodamine hydrobromide;Anisotropine bromide;PD 102807;Nebracetam hydrochloride;Muscarine-d9 iodide;Mazaticol;VU0455691;Arborine;Oxitropium Bromide;Propiverine hydrochloride;VU0152099;MHP 133;YM-58790;Elucaine;Rispenzepine;Phenglutarimid;Rapacuronium bromide;Ambutonium bromide;Temiverine hydrochloride;Procyclidine;M4 mAChR agonist-1;Camylofine Trending […]

For research use only. We do not sell to patients. DL-AP7 CAS No. : 85797-13-3 Biological Activity：DL-AP7 is a competitive NMDA antagonist and an anticonvulsant. DL-AP7 blocks the NMDA-induced convulsions and impairs learning performance in a passive avoidance task in mice. Research Area：Neurological Disease Targets：iGluR Related Small Molecules:CIQ;Quinolinic acid-d3;1-Aminocyclobutanecarboxylic acid;Glycine-1-13C,15N;ZL006;PYD-106;NMDA-IN-2;JAMI1001A;(S)-Willardiine;Fanapanel;(S)-AMPA;L-Glutamic acid-15N,d5;PDZ1 Domain inhibitor peptide TFA;Ifenprodil […]

For research use only. We do not sell to patients. MRS1220 CAS No. : 183721-15-5 Biological Activity：MRS1220, a highly potent and selective human A3 adenosine receptor (hA3AR) antagonist with a Ki of 0.59 nM, has therapeutic potential for the research of diseases of the central nervous system. MRS1220 reduces glioblastoma tumor size and blood vessel […]

For research use only. We do not sell to patients. Avexitide CAS No. : 133514-43-9 Biological Activity：Avexitide (Exendin (9-39)) is a specific and competitive GLP-1 receptor antagonist. Research Area：Metabolic Disease Targets：GCGR Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus; Related Small Molecules:BETP;GLP-1R agonist 4;VU0453379;PF-06291874;Utreglutide;TT-OAD2;Efocipegtrutide;GLP-1 receptor agonist 2;NNC-0640;Cochinchinenin C;{Val1}-Exendin-3/4;GLP-1(28-36)amide TFA;Exendin-4 acetate;Glepaglutide;GLP-1(7-37);GLP-1 […]