Tag: Antagonist

For research use only. We do not sell to patients. GABAA receptor agent 4 CAS No. : 2035203-91-7 Biological Activity：GABAA receptor agent 4 (compound 1e) is a potent γ-GABAAR antagonist with an Ki of 0.18 µM. GABAA receptor agent 4 efficiently rescues inhibition of T cell proliferation. GABAA receptor agent 4 has the immunomodulatory potential. […]

For research use only. We do not sell to patients. (S)-Mirtazapine D3 Biological Activity：(S)-Mirtazapine D3 ((S)-Org3770 D3) is a deuterium labeled (S)-Mirtazapine. (S)-Mirtazapine is a S(+)-enantiomer of Mirtazapine with pronociceptive properties in an animal model of acute thermal nociception.(S)-Mirtazapine is a stereoselective 5-HT2 receptor antagonist. (S)-Mirtazapine is metabolized by CYP2D6 and CYP1A2. Research Area：Neurological Disease […]

For research use only. We do not sell to patients. opigolix CAS No. : 912587-25-8 Biological Activity：Opigolix is a Gonadotropin-releasing hormone (GnRH) receptor antagonist, used for the research of endometriosis and rheumatoid arthritis. Research Area：Inflammation/Immunology|Endocrinology Targets：GnRH Receptor Related Small Molecules:(R)-Elagolix;Linzagolix;Relugolix-d6;[D-Ala6]-LH-RH;Relugolix;Teverelix;Alarelin Acetate;[D-Leu6, Val7]-LH-RH (1-9) Ethyl Amide;Kisspeptin 13;sGnRH-A;Lecirelin;GnRH-R antagonist 1;Ozarelix;LH-RH (7-10);BAY-298;Acyline;GnRH-I;Lamprey LH-RH I;BAY-784;BAY 1214784;GnRH antagonist 2;[D-Lys6]-LH-RH Trending […]

For research use only. We do not sell to patients. Galantide CAS No. : 138579-66-5 Biological Activity：Galantide, a non-specific galanin receptor antagonist, is a peptide consisting of fragments of galanin and substance P. Galantide recognizes two classes of galanin binding sites (KD

For research use only. We do not sell to patients. Ex26 CAS No. : 1233332-37-0 Biological Activity：Ex26 (S1P1-IN-Ex26) is a potent and selective sphingosine 1-phosphate receptor 1 (S1P1) antagonist (IC50=0.93 nM). Ex26 shows >3,000-fold selectivity for S1P1 over other Sphingosine 1-phosphate receptors. Ex26 can be used in experimental autoimmune encephalomyelitis reseach. Research Area：Metabolic Disease|Inflammation/Immunology|Neurological Disease […]

For research use only. We do not sell to patients. TCN 201 CAS No. : 852918-02-6 Biological Activity：TCN 201 is a potent, selective and non-competitive antagonist of GluN1/GluN2A NMDA receptor, with a pIC50 of 6.8. TCN 201 is selective for GluN1/GluN2A NMDA receptor over GluN1/GluN2B NMDA receptor (pIC50

For research use only. We do not sell to patients. RS-127445 CAS No. : 199864-87-4 Biological Activity：RS-127445 is a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist with a pKi of 9.5. RS-127445 shows 1000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites. Research Area：Neurological Disease Targets：5-HT […]

For research use only. We do not sell to patients. BAY 73-1449 CAS No. : 693790-96-4 Biological Activity：BAY 73-1449 is a selective antagonist of prostacyclin receptor (IP), with high potency (IC50 of less than 0.1 nM) in cAMP assays in Human HEL cells and rat DRG. BAY 73-1449 can be used in the research of […]

For research use only. We do not sell to patients. Mepyramine maleate CAS No. : 59-33-6 Biological Activity：Mepyramine maleate, a first generation antihistamine, is an antagonist of histamine H1 receptor, with Kds of 0.8 nM, 5200 nM and >3000 nM for H1, H2, and H3 receptor, respectively, and a pKd of 9.4 for H1 receptor. […]

For research use only. We do not sell to patients. Umeclidinium-d10 bromide Biological Activity：Umeclidinium-d10 bromide (GSK573719A-d10) is the deuterium labeled Umeclidinium bromide. Umeclidinium bromide is a novel mAChR antagonist. The affinity (Ki) of Umeclidinium bromide for the cloned human M1-M5 mAChRs ranges from 0.05 to 0.16 nM. Research Area：Inflammation/Immunology Targets：mAChR Related Small Molecules:VU0357017 hydrochloride;TBPB;Imidafenacin;Sabcomeline;MK-6884;Brompheniramine-d6 maleate;Navafenterol […]