Tag: Antagonist

For research use only. We do not sell to patients. PACAP (6-38), human, ovine, rat TFA Biological Activity：PACAP (6-38), human, ovine, rat TFA is a potent PACAP receptor antagonist with IC50s of 30, 600, and 40 nM for PACAP type I receptor, PACAP type II receptor VIP1, and PACAP type II receptor VIP2, respectively. Research […]

For research use only. We do not sell to patients. Aprocitentan-d4 Biological Activity：Aprocitentan D4 (ACT-132577 D4) is a deuterium labeled Aprocitentan. Aprocitentan is a major and pharmacologically active metabolite of Macitentan. Aprocitentan is dual ETA/ETB antagonist with IC50s of 3.4 nM and 987 nM, and pA2 valus of 6.7 and 5.5, respectively. Research Area：Endocrinology|Cardiovascular Disease […]

For research use only. We do not sell to patients. MRS2279 CAS No. : 367909-40-8 Biological Activity：MRS2279 is a selective and high affinity P2Y1 receptor antagonist, with a Ki of 2.5 nM and an IC50 of 51.6 nM. MRS2279 competitively inhibits ADP-promoted platelet aggregation with an apparent affnity (pKB=8.05)[2][3]. Research Area：Neurological Disease Targets：P2Y Receptor Related […]

For research use only. We do not sell to patients. Mavoglurant CAS No. : 543906-09-8 Biological Activity：Mavoglurant (AFQ056) is a potent, selective, non-competitive and orally active mGluR5 antagonist, with an IC50 of 30 nM. Mavoglurant shows a >300 fold selectivity for the mGluR5 over all targets (238) tested. Mavoglurant can be used for the research […]

For research use only. We do not sell to patients. Acenocoumarol-d5 CAS No. : 1185071-64-0 Biological Activity：Acenocoumarol-d5 is the deuterium labeled Acenocoumarol. Acenocoumarol is an anticoagulant that functions as a Vitamin K antagonist[2]. Research Area：Cardiovascular Disease Targets：Others Related Small Molecules:Immune initiator-1;Obiltoxaximab;DIBAC-GGFG-NH2CH2-Dxd;Cyanine5.5 maleimide chloride;Cymarin;Z-Glycine;2-Deoxy-2-fluoro-D-glucose-13C,d7;Water-18O;Fmoc-N-Me-D-Ala-OH;3,5-Diiodo-L-tyrosine;N3-Pen-Dde;Zimeldine-d6;Ornidazole diol;Nylidrin hydrochloride;PFI-653;N-Arachidonoyl Taurine-d4;OVA Peptide (323-339);((3-Fluorophenyl)sulfonyl)glycine;7ß-Hydroxycholesterol-d7;MALAT1-IN-1;Sibiricose A1;Mefruside-d3;Ethacrynic acid mercapturate-d3;FLAG peptide;Neocurdione Trending products：Recombinant Proteins  […]

For research use only. We do not sell to patients. (R)-(+)-Atenolol CAS No. : 56715-13-0 Biological Activity：(R)-(+)-Atenolol is the less active enantiomer of the (R,S)-atenolol. (R,S)-atenolol is a β-adrenergic receptor antagonist[2]. Research Area：Others Targets：Adrenergic Receptor Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;GPCR/G Protein Compound Library;Neuronal Signaling […]

For research use only. We do not sell to patients. Substance P Receptor Antagonist 1 CAS No. : 225526-17-0 Biological Activity：Substance P Receptor Antagonist 1 has the potential function in central nervous system disorders, respiratory, inflammatory diseases and gastrointestinal disorders. Research Area：Inflammation/Immunology|Neurological Disease Targets：Neurokinin Receptor Related Small Molecules:(β-Ala8)-Neurokinin A (4-10);Talnetant hydrochloride;Pavinetant;MEN11467;(D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance P;Vapreotide acetate;Rolapitant;Eprazinone dihydrochloride;Orvepitant maleate;Netupitant […]

For research use only. We do not sell to patients. G15 CAS No. : 1161002-05-6 Biological Activity：G15 is a high affinity and selective G-protein-coupled estrogen receptor (GPER/GPR30) antagonist with a Ki of 20 nM[2]. Research Area：Cancer Targets：Estrogen Receptor/ERR Related Screening Libraries:Bioactive Compound Library Plus;Anti-Cancer Compound Library;Anti-Breast Cancer Compound Library;Nuclear Receptor Compound Library; Related Small Molecules:DS20362725;LSD1/ER-IN-1;Giredestrant;Avobenzone;Estriol-d3;Chrysin;ERRγ […]

For research use only. We do not sell to patients. ADRA1D receptor antagonist 1 free base CAS No. : 1191908-24-3 Biological Activity：ADRA1D receptor antagonist 1 (free base) (compound (R)-9s) is an orally active, potent and selective human α1D-adrenoceptor (α1D-AR) antagonist (Ki=1.6 nM). ADRA1D receptor antagonist 1 (free base) dose-dependently inhibits bladder contraction with an IC30 […]

For research use only. We do not sell to patients. Ziprasidone mesylate CAS No. : 185021-64-1 Biological Activity：Ziprasidone (CP-88059) mesylate is an orally active combined 5-HT and dopamine receptor antagonist. Ziprasidone mesylate has affinities for Rat D2 (Ki=4.8 nM), 5-HT2A (Ki=0.42 nM) and 5-HT1A (Ki=3.4 nM). Research Area：Neurological Disease Targets：Dopamine Receptor|5-HT Receptor Related Small Molecules:F […]