Tag: Antagonist

For research use only. We do not sell to patients. JKC363 TFA Biological Activity：JKC363 TFA, a selective melanocortin MC4 receptor antagonist, has a 90-fold higher affinity at the MC4 receptor (IC50=0.5 nM) than at the MC3 receptor (44.9 nM). JKC363 TFA blocks the stimulatory effect of α-MSH on TRH release. Anti-hyperalgesic effect[2]. Research Area：Neurological Disease […]

For research use only. We do not sell to patients. Imaradenant CAS No. : 1321514-06-0 Biological Activity：AZD4635 (HTL1071) is a potent, selective and orally active adenosine A2A receptor (A2AR) antagonist. AZD4635 binds to human A2AR with a Ki of 1.7 nM and shows >30-fold selectivity over other adenosine receptors. Research Area：Cancer Targets：Adenosine Receptor Related Screening […]

For research use only. We do not sell to patients. Naloxegol-d5 oxalate Biological Activity：Naloxegol-d5 (oxalate) is deuterium labeled Naloxegol (oxalate). Naloxegol oxalate (NKTR-118 oxalate; AZ-13337019 oxalate) is a μ-opioid-receptor antagonist. Naloxegol oxalate inhibits opioid binding in μ-opioid receptors in the gastrointestinal tract and effective for alleviating opioid-induced constipation[2]. Research Area：Neurological Disease Targets：Opioid Receptor Related Small […]

For research use only. We do not sell to patients. MRT-83 hydrochloride CAS No. : 1359944-60-7 Biological Activity：MRT-83 (hydrochloride) is the potent antagonist of Smoothened (Smo) receptor. MRT-83 (hydrochloride) inhibits the Hedgehog (Hh) signaling pathway and BODIPY-cyclopamine binding to human Smo. MRT-83 (hydrochloride) has the potential for researching cancer disease. Research Area：Cancer Targets：Smo Related Screening […]

For research use only. We do not sell to patients. VUF10166 CAS No. : 155584-74-0 Biological Activity：VUF10166 is a potent and high-affinity 5-HT3 receptor antagonist, with Ki values of 0.04 nM (5-HT3A) and 22 nM (5-HT3AB). VUF10166 inhibits 5-HT-induced responses at 5-HT3A and 5-HT3AB receptors at nanomolar concentrations. At 5-HT3 receptor, VUF10166 at higher concentrations […]

For research use only. We do not sell to patients. Ebopiprant CAS No. : 2005486-31-5 Biological Activity：Ebopiprant (OBE022) is an oral and selective prostaglandin F2α (PGF2α) receptor antagonist, with Kis of 1 nM, 26 nM for human and rat FP receptors, respectively. Research Area：Endocrinology Targets：Prostaglandin Receptor Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library […]

For research use only. We do not sell to patients. MK-7246 S enantiomer Biological Activity：MK-7246 S enantiomer is the less active enantiomer of MK-7246. MK-7246 is a potent and selective CRTH2 antagonist. Research Area：Inflammation/Immunology|Endocrinology Targets：Prostaglandin Receptor Related Small Molecules:Omidenepag isopropyl;DG-041;8-Isoprostaglandin E2;BAY-6672;trans-Isoferulic acid;GSK-269984A;KMN-80;SC 51089;p-Hydroxycinnamic acid;Pexopiprant;Dinoprost;Sulprostone;Prostaglandin E2;CAY10471 Racemate;Fevipiprant;TG6-10-1;Cicaprost;ER-819762;MRE-269-d6;ONO-8130;KAG-308;KF 13218;Prostaglandin E2-d4 Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  […]

For research use only. We do not sell to patients. PSB-0788 CAS No. : 1027513-54-7 Biological Activity：PSB-0788 is a new selective high-affinity A2B antagonist with IC50 value of 3.64 nM and Ki value of 0.393 nM, respeactively. PSB-0788 can be used for the research for chronic inflammatory lung diseases. Research Area：Cancer|Infection Targets：Adenosine Receptor Related Small […]

For research use only. We do not sell to patients. BQ-788 sodium salt CAS No. : 156161-89-6 Biological Activity：BQ-788 sodium salt is a potent and selective ETB receptor antagonist, inhibiting ET-1 binding to ETB receptors with an IC50 of 1.2 nM in human Girrardi heart cells. Research Area：Cardiovascular Disease|Endocrinology|Cancer Targets：Endothelin Receptor Related Screening Libraries:Clinical Compound […]

For research use only. We do not sell to patients. R121919 CAS No. : 195055-03-9 Biological Activity：R121919 (NBI30775) is a potent small-molecule CRF1 receptor antagonist with a Ki of 2 to 5 nM for the CRF1 receptor and over 1000-fold weaker activity at the CRF2 receptor, CRF-binding protein, or 70 other receptor types. Research Area：Neurological […]