Tag: Antagonist

For research use only. We do not sell to patients. Mizolastine-13C,d3 Biological Activity：Mizolastine-13C,d3 is the 13C- and deuterium labeled Mizolastine. Research Area：Inflammation/Immunology|Endocrinology Targets：Histamine Receptor Related Small Molecules:Tripelennamine;Brompheniramine-d6 maleate;Samelisant;Chlorphenoxamine;H3 receptor-MO-1;Diphenhydramine;ABT-239;Ketotifen fumarate;Ranitidine;Cetirizine;Diphenylpyraline hydrochloride;Loratadine-d5;Phenyltoloxamine;Ritanserin;BMY-25271;FRG8701;Mecamylamine hydrochloride;Cimetidine sulfoxide;Brompheniramine maleate;Tecastemizole;Famotidine-13C,d3;Bromazine-d6 hydrochloride Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides […]

For research use only. We do not sell to patients. AZD9496 CAS No. : 1639042-08-2 Biological Activity：AZD9496 is a potent and selective estrogen receptor (ERα) antagonist with an IC50 of 0.28 nM. AZD9496 is an orally bioavailable selective oestrogen receptor degrader (SERD). Research Area：Cancer Targets：Estrogen Receptor/ERR Related Screening Libraries:Clinical Compound Library Plus;Bioactive Compound Library Plus;Anti-Cancer […]

For research use only. We do not sell to patients. Cetirizine Impurity C CAS No. : 83881-59-8 Biological Activity：Cetirizine Impurity C is an impurity of Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist[1][2]. Research Area：Endocrinology|Inflammation/Immunology Targets：Histamine Receptor Related Small Molecules:Tripelennamine;Brompheniramine-d6 maleate;Samelisant;Chlorphenoxamine;H3 receptor-MO-1;Diphenhydramine;ABT-239;Ketotifen […]

For research use only. We do not sell to patients. Triptophenolide CAS No. : 74285-86-2 Biological Activity：Triptophenolide is a colorless crystalline plate isolated from ethyl acetate extracts of Tripterygium wilfordii. IC50 value: Target: In vitro: Triptophenolide can remarkably inhibit the delayed type hypersensitivity (DTH) reaction induced by DNCB and BSA; and diminished the peripheral blood […]

For research use only. We do not sell to patients. NF449 octasodium CAS No. : 627034-85-9 Biological Activity：NF449 octasodium is a highly potent P2X1 receptor antagonist, with IC50s of 0.28, 0.69, and 120 nM for rP2X1, rP2X1+5, P2X2+3, respectively. NF449 octasodium is a Gsα-selective G Protein antagonist. NF449 octasodium suppresses the rate of GTP[γS] binding […]

For research use only. We do not sell to patients. Imnopitant dihydrochloride CAS No. : 290296-52-5 Biological Activity：Imnopitant dihydrochloride is a neurokinin NK1 receptor antagonist. Research Area：Neurological Disease Targets：Neurokinin Receptor Related Small Molecules:(β-Ala8)-Neurokinin A (4-10);Talnetant hydrochloride;Pavinetant;MEN11467;(D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance P;Vapreotide acetate;Rolapitant;Eprazinone dihydrochloride;Orvepitant maleate;Netupitant metabolite Monohydroxy Netupitant;SB-222200;Senktide;GR 87389;Hemokinin 1, human;Neurokinin A TFA;[Glp6] Substance P (6-11);[Lys5,MeLeu9,Nle10]-NKA(4-10) TFA;[Pro9]-Substance P;Befetupitant;Hemokinin 1 (mouse);Substance […]

For research use only. We do not sell to patients. PIT CAS No. : 56583-49-4 Biological Activity：PIT (2,2′-Pyridylisatogen tosylate) is a selective and non-competitive antagonist of P2Y1 receptor with an IC50 value of 0.14 μM for human P2Y1 receptor. PIT antagonizes P2Y1 receptor signaling without affecting nucleotide binding. PIT is an irreversible antagonist of responses […]

For research use only. We do not sell to patients. Chlorpheniramine maleate CAS No. : 113-92-8 Biological Activity：Chlorpheniramine maleate is an histamine H1 receptor antagonist with IC50 of 12 nM. Target: Histamine H1 Receptor Chlorpheniramine inhibits the proliferation of MCF-7, MDA-MB 231, and Ehrlich cells in a dose-response manner, and significantly reduces the ornithine decarboxylase […]

For research use only. We do not sell to patients. SYM2206 CAS No. : 173952-44-8 Biological Activity：SYM2206 is a potent and non-competitive AMPA receptor antagonist, with an IC50 of 1.6 μM. SYM2206 blocks Nav1.6-mediated persistent currents[2]. Research Area：Neurological Disease Targets：iGluR Related Screening Libraries:Bioactive Compound Library Plus;Membrane Transporter/Ion Channel Compound Library;Neuronal Signaling Compound Library;Neurotransmitter Receptor Compound […]

For research use only. We do not sell to patients. A-804598 CAS No. : 1125758-85-1 Biological Activity：A-804598 is a CNS penetrant, competitive and selective P2X7 receptor antagonist with IC50s of 9 nM, 10 nM and 11 nM for mouse, rat and human P2X7 receptors, respectively. Research Area：Cancer Targets：P2X Receptor Related Screening Libraries:Bioactive Compound Library Plus;Membrane […]