Tag: Antagonist

For research use only. We do not sell to patients. A-317491 CAS No. : 475205-49-3 Biological Activity：A-317491 is a potent, selective and non-nucleotide antagonist of P2X3 and P2X2/3 receptors, with Kis of 22, 22, 9, and 92 nM for hP2X3, rP2X3, hP2X2/3, and rP2X2/3, respectively. A-317491 is highly selective (IC50>10 μM) over other P2 receptors […]

For research use only. We do not sell to patients. MJ15 CAS No. : 944154-76-1 Biological Activity：MJ15 is a potent and selective CB1 receptor antagonist with a Ki of 27.2 pM and an IC50 of 118.9 pM for rat CB1 receptors. MJ15 exhibits potency in obesity and hyperlipidemia models. MJ15 inhibits food intake and increases […]

For research use only. We do not sell to patients. Fosaprepitant dimeglumine CAS No. : 265121-04-8 Biological Activity：Fosaprepitant dimeglumine (MK-0517) is a prodrug of Aprepitant (HY-10052). Fosaprepitant dimeglumine is a neurokinin-1 receptor antagonist, which is development for the prevention of chemotherapy-induced nausea and vomiting (CINV). Research Area：Neurological Disease|Endocrinology|Cancer Targets：Neurokinin Receptor Related Screening Libraries:Drug Repurposing Compound […]

For research use only. We do not sell to patients. 6-Raloxifene-β-D-glucopyranoside CAS No. : 334758-18-8 Biological Activity：6-Raloxifene-β-D-glucopyranoside, a derivative of Raloxifene, is a benzothiophene glucuronidated at the 6′ postion. 6-Raloxifene-β-D-glucopyranoside is a selective and orally active estrogen receptor antagonist. 6-Raloxifene-β-D-glucopyranoside can be used for inhibiting bone loss and resorption, and lowering lipid levels. 6′-Raloxifene-β-D-glucopyranoside, compound […]

For research use only. We do not sell to patients. GR 113808 CAS No. : 144625-51-4 Biological Activity：GR 113808 is a potent and highly selective 5-HT4 receptor antagonist (pKb= 8.8). GR 113808 shows 300-fold selectivity over 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C and 5-HT3 receptors. Research Area：Inflammation/Immunology|Neurological Disease Targets：5-HT Receptor Related Screening Libraries:Bioactive Compound Library Plus;GPCR/G Protein Compound […]

For research use only. We do not sell to patients. TRPV antagonist 1 CAS No. : 1192871-27-4 Biological Activity：TRPV antagonist 1 is a transient receptor potential vanilloid (TRPV) antagonist, with an IC50 of < 250 nM. Research Area：Inflammation/Immunology Targets：TRP Channel Related Small Molecules:V116517;GSK2332255B;Pregnenolone monosulfate sodium;TRPC5-IN-4;OptoBI-1;SB-705498;TRPC3/6-IN-1;ABT-239;Pyr3;Asivatrep;Ononetin;TRPM8 antagonist 3;FEMA 4809;Hydroxy-α-sanshool;GsMTx4 TFA;TRPM4-IN-1;Palvanil;Pregnenolone monosulfate sodium-13C2,d2;Capsazepine;MSP-3;TRPM4-IN-2;Pregnenolone-d4-1;Umbellulone;Icilin;DS88790512;ML-SA1 Trending products：Recombinant Proteins  |  […]

For research use only. We do not sell to patients. PD173212 CAS No. : 217171-01-2 Biological Activity：PD173212 is a selective N-type voltage sensitive calcium channel (VSCC) blocker, with an IC50 of 36 nM in IMR-32 assays. Research Area：Neurological Disease Targets：Calcium Channel Related Screening Libraries:Bioactive Compound Library Plus;Membrane Transporter/Ion Channel Compound Library;Neuronal Signaling Compound Library;Neuroprotective Compound […]

For research use only. We do not sell to patients. Mebhydrolin CAS No. : 524-81-2 Biological Activity：Mebhydrolin is a specific histamine H1 receptor antagonist. Research Area：Inflammation/Immunology|Endocrinology Targets：Histamine Receptor Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;GPCR/G Protein Compound Library;Immunology/Inflammation Compound Library;Neuronal Signaling Compound Library;FDA-Approved Drug Library;Drug Repurposing […]

For research use only. We do not sell to patients. Ondansetron hydrochloride CAS No. : 99614-01-4 Biological Activity：Ondansetron hydrochloride (GR 38032 hydrochloride; SN 307 hydrochloride) is a serotonin 5-HT3 receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy. Target: 5- HT Receptor IC50 Value: in vitro: 5-HT evoked transient inward […]

For research use only. We do not sell to patients. Ro 46-2005 CAS No. : 150725-87-4 Biological Activity：Ro 46-2005 is a novel synthetic non-peptide endothelin receptor antagonist, inhibits the specific binding of 125I-ET-1 to human vascular smooth muscle cells (ETA receptor) with IC50 of 220 nM. IC50 value: 220 nM (ETA) [2] Target: Endothelin in […]