Tag: Antagonist

For research use only. We do not sell to patients. Midaglizole hydrochloride CAS No. : 79689-25-1 Biological Activity：Midaglizole hydrochloride (DG5128) is a preferential α2-adrenoceptor antagonist. Midaglizole hydrochloride (DG5128) exhibits 7.4 times higher affinity (pKi=6.28) toward α2-adrenoceptor than α1-adrenoceptor. Research Area：Metabolic Disease|Endocrinology Targets：Adrenergic Receptor Related Screening Libraries:Bioactive Compound Library Plus;GPCR/G Protein Compound Library;Neuronal Signaling Compound Library;Endocrinology […]

For research use only. We do not sell to patients. Glycopyrrolate CAS No. : 596-51-0 Biological Activity：Glycopyrrolate (Glycopyrronium bromide) is a muscarinic competitive antagonist used as an antispasmodic. IC50 Value: Target: mAChR (Muscarinic acetylcholine receptor M1) in vitro: Glycopyrrolate showed no selectivity in its binding to the M1-M3 receptors. Kinetics studies, however, showed that glycopyrrolate […]

For research use only. We do not sell to patients. ACTH (11-24) (acetate) Biological Activity：ACTH (11-24) (acetate) is an adrenocorticotropic hormone (ACTH) receptor antagonist. ACTH (11-24) is a fragment of adrenocorticotropic and induces cortisol release. ACTH (11-24) can be used for the research of central nervous system. Research Area：Neurological Disease Targets：Melanocortin Receptor Related Small Molecules:Bremelanotide;MSG606 […]

For research use only. We do not sell to patients. CD2665 CAS No. : 170355-78-9 Biological Activity：CD2665 is an orally active and selective RAR-β,γ antagonist, with Kd values of 306 nM, 110 nM for RAR-β and RAR-γ, repectively[3]. Research Area：Metabolic Disease Targets：RAR/RXR Related Screening Libraries:Bioactive Compound Library Plus;Metabolism/Protease Compound Library;Orally Active Compound Library;Transcription Factor-Targeted Library;Protein-protein […]

For research use only. We do not sell to patients. Aticaprant CAS No. : 1174130-61-0 Biological Activity：Aticaprant (CERC-501) is a potent and centrally-penetrant kappa opioid receptor antagonist with a Ki of 0.807 nM. Research Area：Neurological Disease Targets：Opioid Receptor Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;GPCR/G Protein Compound Library;Neuronal Signaling […]

For research use only. We do not sell to patients. SANT 2 CAS No. : 329196-48-7 Biological Activity：SANT 2 is a potent antagonist of Hh-signaling pathway. Hedgehog (Hh) signaling plays an important role in cell signaling of embryonic development and adult tissue homeostasis. SANT 2 has the potential for the research of several malignancies including […]

For research use only. We do not sell to patients. Cetirizine Impurity D CAS No. : 346451-15-8 Biological Activity：Cetirizine Impurity D is an impurity of Cetirizine. Cetirizine, a second-generation antihistamine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response[2][3]. Research Area：Endocrinology|Inflammation/Immunology Targets：Histamine […]

For research use only. We do not sell to patients. Tropisetron Hydrochloride CAS No. : 105826-92-4 Biological Activity：Tropisetron Hydrochloride (SDZ-ICS-930) is a selective 5-HT3 receptor antagonist and α7-nicotinic receptor agonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor. IC50 value: 70.1 ± 0.9 nM Target: 5-HT3 receptor; α7-nicotinic receptor in vitro: Retinal […]

For research use only. We do not sell to patients. Bromopride CAS No. : 4093-35-0 Biological Activity：Bromopride is a dopamine antagonist with prokinetic properties, widely used as an antiemetic. Research Area：Neurological Disease Targets：Dopamine Receptor Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;GPCR/G Protein Compound Library;Neuronal Signaling Compound […]

For research use only. We do not sell to patients. Oxitropium Bromide CAS No. : 30286-75-0 Biological Activity：Oxitropium bromide is an mAChR antagonist used as an anticholinergic bronchodilator drug for the treatment of asthma and chronic obstructive pulmonary disease. Research Area：Inflammation/Immunology Targets：mAChR Related Small Molecules:VU0357017 hydrochloride;TBPB;Imidafenacin;Sabcomeline;MK-6884;Brompheniramine-d6 maleate;Navafenterol saccharinate;DREADD agonist 21;Cyclobuxine D;Brompheniramine maleate;Dexetimide;Anisodamine hydrobromide;Anisotropine bromide;PD 102807;Nebracetam […]