Tag: Antagonist

For research use only. We do not sell to patients. AZ8838 CAS No. : 2100285-41-2 Biological Activity：AZ8838 is a potent, competitive, allosteric, orally active non-peptide small molecule antagonist of PAR2 with a pKi of 6.4 for hPAR2. Research Area：Inflammation/Immunology Targets：Protease Activated Receptor (PAR) Related Small Molecules:ENMD-1068 hydrochloride;Atopaxar hydrobromide;SLIGRL-NH2 TFA;SCH79797 dihydrochloride;AC-55541;TRAP-6-IN-1;TRAP-6 amide TFA;I-191;ML354;Parstatin(human);UDM-001651;Protease-Activated Receptor-1, PAR-1 Agonist;TFLLR-NH2(TFA);tcY-NH2;VKGILS-NH2 […]

For research use only. We do not sell to patients. Ro 25-6981 CAS No. : 169274-78-6 Biological Activity：Ro 25-6981 is a potent, selective and activity-dependent NR2B subunit specific NMDA receptor antagonist. Ro 25-6981 shows anticonvulsant and anti-parkinsonian activity. Ro 25-6981 has the potential for the research of parkinson’s disease (PD)[2][3]. Research Area：Neurological Disease Targets：iGluR Related […]

For research use only. We do not sell to patients. PF-5274857 hydrochloride CAS No. : 1613439-62-5 Biological Activity：PF-5274857 hydrochloride is a potent, selective, orally active and brain-penetrant antagonist of Smo, with an IC50 of 5.8 nM and Ki of 4.6 nM. PF-5274857 hydrochloride has potential for research of tumor types including brain tumors and brain […]

For research use only. We do not sell to patients. CAY10471 CAS No. : 627865-18-3 Biological Activity：CAY10471 (TM30089) is a potent, selective, and orally active prostaglandin D2 receptor CRTH2 antagonist. CAY10471 attenuates the progression of tubulointerstitial fibrosis and chronic contact hypersensitivity (CHS) in animal model[2][3]. Research Area：Inflammation/Immunology Targets：Prostaglandin Receptor Related Small Molecules:Omidenepag isopropyl;DG-041;8-Isoprostaglandin E2;BAY-6672;trans-Isoferulic acid;GSK-269984A;KMN-80;SC 51089;p-Hydroxycinnamic […]

For research use only. We do not sell to patients. Tezosentan CAS No. : 180384-57-0 Biological Activity：Tezosentan (RO 610612) is an endothelin (ET) receptor antagonist, with pA2s of 9.5, 7.7 for ETA and ETB receptors, respectively. Research Area：Cancer|Neurological Disease|Cardiovascular Disease|Endocrinology Targets：Endothelin Receptor Related Small Molecules:BQ-788;[Asn18] Endothelin-1, human;Endothelin-3, human, mouse, rabbit, rat TFA;IRL 2500;Sarafotoxin S6c;Sarafotoxin S6a;ANP […]

For research use only. We do not sell to patients. XY018 CAS No. : 1873358-87-2 Biological Activity：XY018 is a potent ROR-γ-selective antagonist. XY018 inhibits ROR-γ constitutive activity in 293T cells with high potency (EC50, 190 nM). XY018 binds to the ROR-γ hydrophobic ligand binding domain (LBD). Research Area：Cancer|Inflammation/Immunology Targets：ROR Related Screening Libraries:Bioactive Compound Library Plus;Immunology/Inflammation […]

For research use only. We do not sell to patients. Anisodamine CAS No. : 55869-99-3 Biological Activity：Anisodamine (6-Hydroxyhyoscyamine), a belladonna alkaloid, is a non-subtype-selective muscarinic, and also a nicotinic cholinoceptor antagonist. Anisodamine employs in traditional Chinese medicine for many ailments, mainly to improve the microcirculation in states of shock, and also in organophosphate poisoning[2]. Research […]

For research use only. We do not sell to patients. CXCR2 antagonist 2 CAS No. : 2647464-91-1 Biological Activity：CXCR2 antagonist 2 is a potent CXCR2 antagonist for cancer immunotherapy with an IC50 value of 95 nM. Research Area：Cancer Targets：CXCR Related Screening Libraries:Bioactive Compound Library Plus; GPCR/G Protein Compound Library;Immunology/Inflammation Compound Library;Anti-Cancer Compound Library;Small Molecule Immuno-Oncology […]

For research use only. We do not sell to patients. PEO-IAA CAS No. : 6266-66-6 Biological Activity：PEO-IAA is an indole-3-acetic acid (IAA) antagonist. PEO-IAA is an auxin antagonist that binds to transport inhibitor response 1/auxin signaling F-box proteins (TIR1/AFBs). Research Area：Others Targets：Others Related Screening Libraries:Bioactive Compound Library Plus; Related Small Molecules:Immune initiator-1;Obiltoxaximab;DIBAC-GGFG-NH2CH2-Dxd;Cyanine5.5 maleimide chloride;Cymarin;Z-Glycine;2-Deoxy-2-fluoro-D-glucose-13C,d7;Water-18O;Fmoc-N-Me-D-Ala-OH;3,5-Diiodo-L-tyrosine;N3-Pen-Dde;Zimeldine-d6;Ornidazole diol;Nylidrin […]

For research use only. We do not sell to patients. MRS-1191 CAS No. : 185222-90-6 Biological Activity：MRS-1191 is a potent and selective A3 adenosine receptor antagonist with a KB value of 92 nM, a Ki value of 31.4 nM for human A3 receptor and an IC50 of 120 nM for CHO cells. Research Area：Neurological Disease […]