Tag: Antagonist

For research use only. We do not sell to patients. Bepridil hydrochloride CAS No. : 68099-86-5 Biological Activity：Bepridil hydrochloride (CERM 1978) is a calcium channel blocker, with antianginal activity. Research Area：Cardiovascular Disease Targets：Calcium Channel Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;Membrane Transporter/Ion Channel Compound Library;Neuronal Signaling […]

For research use only. We do not sell to patients. UDM-001651 CAS No. : 1477497-01-0 Biological Activity：UDM-001651 is a potent, selective, and orally bioavailable protease-activated receptor 4 (PAR4) antagonist (IC50=4 nM; Kd=1.4 nM). UDM-001651 shows antiplatelet potency (IC50=25 nM) in a γ-thrombin-induced platelet-rich plasma aggregation assay (γ-Thr PRP). Research Area：Cardiovascular Disease Targets：Protease Activated Receptor (PAR) […]

For research use only. We do not sell to patients. SBP-0636457 CAS No. : 1422180-49-1 Biological Activity：SBP-0636457 (SB1-0636457) is a SMAC mimetic, and as an IAP antagonist. SBP-0636457 binds to the BIR-domains of the IAP proteins, with a Ki of 0.27 μM. SBP-0636457 can be used for the research of solid tumors and hematologic cancers[2]. […]

For research use only. We do not sell to patients. PF-998425 CAS No. : 1076225-27-8 Biological Activity：PF-998425 is a potent, selective nonsteroidal androgen receptor (AR) antagonist with an IC50 of 37 nM and 43 nM in AR binding and cellular assays, respectively. PF-998425 has low activity on common receptors and enzymes, such as progesterone receptor. […]

For research use only. We do not sell to patients. Acolbifene hydrochloride CAS No. : 252555-01-4 Biological Activity：Acolbifene (EM-652) hydrochloride, an active metabolite of EM800, is an orally active, cancer-preventing selective estrogen receptor modulator (SERM). Acolbifene (EM-652) hydrochloride inhibits estradiol (E2)-induced transcriptional activity of ERα (IC50=2 nM) and ERβ (IC50=0.4 nM). Acolbifene (EM-652) hydrochloride exerts […]

For research use only. We do not sell to patients. A2A/A3 AR antagonist-1 Biological Activity：A2A/A3 AR antagonist-1 (compound 23) is a dual A2A/A3 adenosine receptor (AR) fluorescent ligand, with Kis of 90 nM and 31.8 nM for hA2A AR and hA3 AR, respectively. Research Area：Inflammation/Immunology Targets：Adenosine Receptor Related Small Molecules:MRS 1523;APNEA;MIPS521;Derenofylline;FSCPX;Theobromine-d3;Inosine-13C;Norisoboldine;N-0861 racemate;Xanthine amine congener dihydrochloride;LUF6096;A1/A3 AR […]

For research use only. We do not sell to patients. 5,7-Dichlorokynurenic acid CAS No. : 131123-76-7 Biological Activity：5,7-Dichlorokynurenic acid (5,7-DCKA) is a selective and competitive antagonist of the glycine site on NMDA receptor with a KB of 65 nM. 5,7-Dichlorokynurenic acid, a derivative of kynurenic acid, reduced NMDA-induced neuron injury in rat cortical cell cultures. […]

For research use only. We do not sell to patients. Cangrelor tetrasodium CAS No. : 163706-36-3 Biological Activity：Cangrelor tetrasodium, an adenosine triphosphate analogue, is a reversible and selective platelet P2Y12 antagonist, with prompt and potent antiplatelet effects. Cangrelor tetrasodium directly blocks adenosine diphosphate (ADP)-induced activation and aggregation of platelets. Cangrelor tetrasodium is also a nonspecific […]

For research use only. We do not sell to patients. VU0455691 CAS No. : 1392443-41-2 Biological Activity：VU0455691 is a potent, selective orthosteric M1 mAChR antagonist (pIC50=6.64; IC50=0.23 µM for hM1). Research Area：Cardiovascular Disease Targets：mAChR Related Small Molecules:VU0357017 hydrochloride;TBPB;Imidafenacin;Sabcomeline;MK-6884;Brompheniramine-d6 maleate;Navafenterol saccharinate;DREADD agonist 21;Cyclobuxine D;Brompheniramine maleate;Dexetimide;Anisodamine hydrobromide;Anisotropine bromide;PD 102807;Nebracetam hydrochloride;Muscarine-d9 iodide;Mazaticol;Arborine;Oxitropium Bromide;Propiverine hydrochloride;VU0152099;MHP 133;YM-58790;Elucaine;Rispenzepine;Phenglutarimid;Rapacuronium bromide;Ambutonium bromide;Temiverine hydrochloride;Procyclidine;M4 […]

For research use only. We do not sell to patients. AZ10606120 dihydrochloride CAS No. : 607378-18-7 Biological Activity：AZ10606120 dihydrochloride is a selective, high affinity antagonist for P2X7 receptor (P2X7R) at human and rat with an IC50 of ~10 nM. AZ10606120 dihydrochloride is little or no effect at other P2XR subtypes. AZ10606120 dihydrochloride has anti-depressant effects and […]