Tag: Antagonist

For research use only. We do not sell to patients. Antifungal agent 22 CAS No. : 2640054-39-1 Biological Activity：Antifungal agent 22 (compound D16) is a potential and orally active antifungal agent for CM (cryptococcal meningitis), with an IC50 of 0.5 μg/mL. Antifungal agent 22 can penetrate the blood-brain barrier and kill the C. neoformans H99 […]

For research use only. We do not sell to patients. LE 300 CAS No. : 274694-98-3 Biological Activity：LE 300 is a potent and selective dopamine D1-like receptor antagonist with Kis of 1.9 nM and 7.5 nM in CHO cell membranes expressing human dopamine D1 and D5 receptors, respectively. LE 300 is an antagonist of the […]

For research use only. We do not sell to patients. Pranlukast CAS No. : 103177-37-3 Biological Activity：Pranlukast is a highly potent, selective and competitive antagonist of peptide leukotrienes. Pranlukast inhibits [3H]LTE4, [3H]LTD4, and [3H]LTC4 bindings to lung membranes with Kis of 0.63±0.11, 0.99±0.19, and 5640±680 nM, respectively. Research Area：Inflammation/Immunology Targets：Leukotriene Receptor|Endogenous Metabolite Related Screening Libraries:Drug […]

For research use only. We do not sell to patients. Mirtazapine CAS No. : 85650-52-8 Biological Activity：Mirtazapine (Org3770) is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent. Mirtazapine is also a 5-HT2, 5-HT3, histamine H1 receptor and α2-adrenoceptor antagonist with pKi values of 8.05, 8.1, 9.3 and 6.95, respectively[2]. Research Area：Inflammation/Immunology|Neurological […]

For research use only. We do not sell to patients. Setiptiline maleate CAS No. : 85650-57-3 Biological Activity：Setiptiline maleate (MO-8282 maleate) is a serotonin receptor antagonist. Setiptiline maleate is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). Setiptiline maleate acts as a norepinephrine reuptake inhibitor, α2-adrenergic receptor antagonist, and […]

For research use only. We do not sell to patients. SAE-14 CAS No. : 1241280-25-0 Biological Activity：SAE-14 (compound SAE-14) is a potent, specific GPR183 antagonist with an IC50 value of 28.5 nM, can antagonize 7α, 25-OHC–induced calcium mobilization with IC50 value below 50 nM in HL-60 cells. GPR183 antagonist-1 can reverse allodynia in mice. Research […]

For research use only. We do not sell to patients. Elubrixin CAS No. : 688763-64-6 Biological Activity：Elubrixin (SB-656933) is a potent, selective, competitive, reversible and orally active CXCR2 antagonist and an IL-8 receptor antagonist. Elubrixin inhibits neutrophil CD11b upregulation (IC50 of 260.7 nM) and shape change (IC50 of 310.5 nM). Elubrixin has the potential for […]

For research use only. We do not sell to patients. AZD 2066 hydrate Biological Activity：AZD 2066 hydrate is a selective, orally active and brain-penetrant antagonist of mGluR5. AZD 2066 hydrate has antinociception effects. Research Area：Neurological Disease Targets：mGluR Related Small Molecules:LY3020371 hydrochloride;ZJ43;FPTQ;(S)-MCPG;mGluR2 modulator 1;VU6010572;Mavoglurant racemate;DFMTI;JNJ16259685;Auglurant;FITM;(-)-Camphoric acid;LY367385 hydrochloride;Cinnabarinic acid;LY379268;AZD 9272;mGluR2 antagonist 1;ABP688;FTIDC;MPPG;L-AP3;VU6001966;VU0155041 sodium;VU 0364439;trans-ACPD;AZD-8529 mesylate;VU 0357121;PHCCC;HexylHIBO;VU0650786 Trending […]

For research use only. We do not sell to patients. JNJ-37822681 dihydrochloride CAS No. : 2108806-02-4 Biological Activity：JNJ-37822681 dihydrochloride is a potent, specific, centrally active, fast-dissociating dopamine D2 receptor antagonist with a moderate binding affinity for the dopamine D2L receptor (Ki =158 nM), which has potential for the treatment of schizophrenia and bipolar disorder[2]. Research […]

For research use only. We do not sell to patients. β-Apo-13-carotenone CAS No. : 17974-57-1 Biological Activity：β-Apo-13-carotenone (D’Orenone) is a naturally occurring β-apocarotenoid functioned as an antagonist of RXRα. Research Area：Others Targets：RAR/RXR Related Screening Libraries:Bioactive Compound Library Plus;Metabolism/Protease Compound Library;Transcription Factor-Targeted Library;Targeted Diversity Library;Protein-protein Interaction Inhibitor Library;Nuclear Receptor Compound Library; Related Small Molecules:AGN 193109-d7;Retinoic acid;AC-261066;Magnolol;ER […]