Tag: Antagonist

For research use only. We do not sell to patients. HexylHIBO CAS No. : 334887-43-3 Biological Activity：HexylHIBO is a potent group I mGluR antagonist with Kbs of 140 and 110 μM at mGlu1a and mGlu5a receptors, respectively. HexylHIBO decreased sEPSC in rat. Research Area：Neurological Disease Targets：mGluR Related Small Molecules:LY3020371 hydrochloride;ZJ43;FPTQ;(S)-MCPG;mGluR2 modulator 1;VU6010572;Mavoglurant racemate;DFMTI;JNJ16259685;Auglurant;FITM;(-)-Camphoric acid;LY367385 hydrochloride;Cinnabarinic […]

For research use only. We do not sell to patients. HTL22562 CAS No. : 2097085-63-5 Biological Activity：HTL22562 is a calcitonin gene-related peptide (CGRP) receptor antagonist for acute treatment of migraine. Research Area：Neurological Disease Targets：CGRP Receptor Related Small Molecules:Vazegepant hydrochloride;Adrenomedullin (16-31), human;MK-3207 Hydrochloride;α-CGRP, rat;Cagrilintide acetate;SUN B8155;Adrenomedullin (11-50), rat;Rat CGRP-(8-37);Atogepant;β-CGRP, human TFA;Calcitonin (salmon);Calcitonin (human);α-CGRP(human);Galcanezumab;Olcegepant;Rimegepant;Calcitonin Gene Related Peptide […]

For research use only. We do not sell to patients. Seltorexant hydrochloride CAS No. : 1293284-49-7 Biological Activity：Seltorexant hydrochloride (JNJ-42847922 hydrochloride) is an orally active, high-affinity, and selective OX2R antagonist (pKi values of 8.0 and 8.1 for human and rat OX2R). Seltorexant hydrochloride crosses the blood-brain barrier and quickly occupies OX2R binding sites in the […]

For research use only. We do not sell to patients. Fluspirilene CAS No. : 1841-19-6 Biological Activity：Fluspirilene is a non-competitive antagonist of L-type calcium channels with an IC50 of 0.03 μM. Fluspirileneis a long-acting injectable depot antipsychotic drug used for schizophrenia. Research Area：Neurological Disease Targets：Calcium Channel Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library […]

For research use only. We do not sell to patients. GSK0660 CAS No. : 1014691-61-2 Biological Activity：GSK0660 is a potent antagonist of PPARβ and PPARδ, with IC50s of 155 nM for both isoforms. Research Area：Metabolic Disease Targets：PPAR Related Screening Libraries:Bioactive Compound Library Plus;Cell Cycle/DNA Damage Compound Library;Anti-Aging Compound Library;Anti-Obesity Compound Library;Transcription Factor-Targeted Library;Human Metabolite Library;Nuclear […]

For research use only. We do not sell to patients. VU0650786 CAS No. : 1809085-30-0 Biological Activity：VU0650786 is a potent and selective CNS penetrant negative allosteric modulator of metabotropic glutamate receptor subtype 3 (mGlu3 NAM), with an IC50 of 392 nM. VU0650786 has antidepressant and anxiolytic activity in rodents. Research Area：Neurological Disease Targets：mGluR Related Screening […]

For research use only. We do not sell to patients. Valsartan-d8 CAS No. : 1089736-72-0 Biological Activity：Valsartan-d8 (CGP 48933-d8) is the deuterium labeled Valsartan. Valsartan (CGP 48933) is an angiotensin II receptor antagonist and has the potential for high blood pressure and heart failure research. Research Area：Cardiovascular Disease|Endocrinology Targets：Angiotensin Receptor Related Small Molecules:Saralasin;A81988;EMD 66684;TD-0212;Angiotensin I/II […]

For research use only. We do not sell to patients. Lorglumide sodium salt CAS No. : 1021868-76-7 Biological Activity：Lorglumide sodium salt (CR-1409 sodium salt) is a potent cholecystokinin (CCK) receptor antagonist. Research Area：Metabolic Disease|Endocrinology Targets：Cholecystokinin Receptor Related Screening Libraries:Bioactive Compound Library Plus;GPCR/G Protein Compound Library;Neuronal Signaling Compound Library;Endocrinology Compound Library;Neurotransmitter Receptor Compound Library;Human Metabolite Library; […]

For research use only. We do not sell to patients. JNJ-7777120 CAS No. : 459168-41-3 Biological Activity：JNJ-7777120 is a potent and selective histamine H4 receptor antagonist (Ki=4.5 nM). JNJ-7777120 effectively blocks histamine-induced migration of mouse tracheal mast cells from connective tissue to epithelial cells. JNJ-7777120 also significantly blocks neutrophil infiltration in a mouse Zymosan-induced peritonitis […]

For research use only. We do not sell to patients. Thiocolchicoside CAS No. : 602-41-5 Biological Activity：Thiocolchicoside is a competitive γ-aminobutyric acid type A (GABAA) receptor antagonist and glycine receptor agonist in the central nervous system. Thiocolchicoside is a semisynthetic sulfur derivative of colchicoside. Thiocolchicoside is a muscle relaxant and has anti-inflammatory, and analgesic properties. […]