Tag: Antagonist

For research use only. We do not sell to patients. PHCCC CAS No. : 179068-02-1 Biological Activity：PHCCC is a Group I mGluR antagonist with an IC50 of 3 μM. PHCCC is a selective positive modulator of mGlu4 receptor. Antiparkinsonian effect[2]. Research Area：Cancer Targets：mGluR Related Screening Libraries:Bioactive Compound Library Plus;GPCR/G Protein Compound Library;Neuronal Signaling Compound Library;Anti-Cancer […]

For research use only. We do not sell to patients. H2L 5765834 CAS No. : 420841-84-5 Biological Activity：H2L 5765834 is an antagonist of lysophosphatidic acid receptors LPA1, LPA3, and LPA5, with IC50s of 94, 752, and 463 nM respectively. Research Area：Cardiovascular Disease Targets：LPL Receptor Related Screening Libraries:Bioactive Compound Library Plus; GPCR/G Protein Compound Library;Immunology/Inflammation Compound […]

For research use only. We do not sell to patients. Coclaurine CAS No. : 486-39-5 Biological Activity：Coclaurine is a class of tetrahydroisoquinoline alkaloids isolated from Sarcopetalum harveyanum. Coclaurine is a nicotinic acetylcholine receptor (nAChRs) antagonist[2]. Research Area：Neurological Disease Targets：nAChR Related Small Molecules:Spinosad;Pyrantel;NS 9283;Myosmine-d4;Benzethonium chloride;Dihydro-β-erythroidine;A-867744;Catestatin;Asoxime dichloride;α7 nAchR-JAK2-STAT3 agonist 1;AR-R17779 hydrochloride;Mecamylamine hydrochloride;Tropisetron;Zolunicant;S16961;NS3861;(±)-Anatoxin A fumarate;Oxantel;PHA-543613 dihydrochloride;(S)-Dinotefuran;Nelonicline citrate;Cytisinicline;NS 1738;Asoxime-d4 […]

For research use only. We do not sell to patients. Zuclopenthixol-d4 succinate salt CAS No. : 1246833-97-5 Biological Activity：Zuclopenthixol-d4((Z)-Clopenthixol-d4) succinate salt is the deuterium labeled Zuclopenthixol. Zuclopenthixol is a thioxanthene derivative which acts as a mixed dopamine D1/D2 receptor antagonist[2]. Research Area：Neurological Disease Targets：Dopamine Receptor Related Small Molecules:Alizapride hydrochloride;Thioproperazine;Bromopride-d3;Nuciferine;Glaucine;SB-277011 dihydrochloride;MIF-1 TFA;Sulpiride;(Rac)-Razpipadon;Clebopride malate;WAY-100635;Flupentixol-d4 dihydrochloride;Cariprazine-d6 hydrochloride;Itopride-d6 hydrochloride;ONC206;Brexpiprazole […]

For research use only. We do not sell to patients. Olmesartan impurity CAS No. : 154709-18-9 Biological Activity：Olmesartan impurity is an Olmesartan impurity. Olmesartan (RNH-6270) is an angiotensin II receptor (AT1R) antagonist has the potential for high blood pressure study[2]. Research Area：Metabolic Disease Targets：Angiotensin Receptor Related Small Molecules:Saralasin;A81988;EMD 66684;TD-0212;Angiotensin I/II (1-6) (TFA);YS-49;TRV055;TRV056;H-Val-Pro-Pro-OH TFA;Tranilast sodium;Angiotensin amide;L162389;L-159282;CGP48369;Elisartan;Pratosartan;TRV-120027 […]

For research use only. We do not sell to patients. Carotegrast methyl CAS No. : 401905-67-7 Biological Activity：Carotegrast methyl (AJM300) is an orally active and selective α4 integrin antagonist. HCA2969, an active metabolite of Carotegrast methyl, is a specific and dual α4β1/α4β7 integrin antagonist. Carotegrast methyl prevents the development of colitis in mice. Research Area：Inflammation/Immunology […]

For research use only. We do not sell to patients. Calmidazolium chloride CAS No. : 57265-65-3 Biological Activity：Calmidazolium chloride (R 24571) is a calmodulin (CaMK) antagonist, antagonizing CaM-dependent phosphodiesterase and calmodulin-induced activation of erythrocyte Ca2+-transporting ATPase with IC50s of 0.15 and 0.35 μM, respectively. Also in anti-cancer research[2]. Calmidazolium binds to CaMK with a Kd […]

For research use only. We do not sell to patients. MSX-130 CAS No. : 4051-59-6 Biological Activity：MSX-130 is a CXCR4 antagonist. MSX-130 inhibits cancer metastasis. Research Area：Cancer Targets：CXCR Related Screening Libraries:Bioactive Compound Library Plus;GPCR/G Protein Compound Library;Immunology/Inflammation Compound Library;Anti-Cancer Compound Library;Small Molecule Immuno-Oncology Compound Library;Chemokine Compound Library; Related Small Molecules:Nicotinamide N-oxide;FC131;CXCR4 antagonist 2;AMG 487 (S-enantiomer);CXCR4 […]

For research use only. We do not sell to patients. Mesdopetam CAS No. : 1403894-72-3 Biological Activity：Mesdopetam (IRL790) is a dopamine D3 receptor antagonist (Ki=90 nM; IC50=9.8 μM for human recombinant D3 receptor) with psychomotor stabilizing properties. Mesdopetam is used for the research of motor and psychiatric complications in Parkinson disease[2]. Research Area：Neurological Disease Targets：Dopamine […]

For research use only. We do not sell to patients. Bavisant CAS No. : 929622-08-2 Biological Activity：Bavisant (JNJ-31001074) is an orally active, potent, brain-penetrating and highly selective antagonist of the histamine H3 receptor. Bavisant can be used for attention-deficit hyperactivity disorder (ADHD) research[2][3]. Research Area：Neurological Disease|Endocrinology Targets：Histamine Receptor Related Small Molecules:Tripelennamine;Brompheniramine-d6 maleate;Samelisant;Chlorphenoxamine;H3 receptor-MO-1;Diphenhydramine;ABT-239;Ketotifen fumarate;Ranitidine;Cetirizine;Diphenylpyraline hydrochloride;Loratadine-d5;Phenyltoloxamine;Ritanserin;BMY-25271;FRG8701;Mecamylamine […]