Tag: Antagonist

For research use only. We do not sell to patients. CCR4-351 hydrochloride CAS No. : 2174938-71-5 Biological Activity：CCR4-351 hydrochloride is an orally active, potent and selective CCR4 antagonist. CCR4-351 hydrochloride, featuring a novel piperidinyl-azetidine motif, has IC50s of 22 nM and 50 nM in the calcium flux and CTX assay. CCR4-351 hydrochloride has antitumor activity. […]

For research use only. We do not sell to patients. SGS518 oxalate CAS No. : 445441-27-0 Biological Activity：SGS518 oxalate is a selective 5-HT6R antagonist. SGS518 oxalate can be used for the research of cognitive impairments such as amnesia, anxiety and depression, and it is effective in protecting mouse retina at high doses[1]

For research use only. We do not sell to patients. HJC0350 CAS No. : 885434-70-8 Biological Activity：HJC0350 is a potent and specific EPAC2 antagonist with an IC50 of 0.3 µM. Research Area：Cancer Targets：Others Related Screening Libraries:Bioactive Compound Library Plus;Anti-Cancer Compound Library; Related Small Molecules:Immune initiator-1;Obiltoxaximab;DIBAC-GGFG-NH2CH2-Dxd;Cyanine5.5 maleimide chloride;Cymarin;Z-Glycine;2-Deoxy-2-fluoro-D-glucose-13C,d7;Water-18O;Fmoc-N-Me-D-Ala-OH;3,5-Diiodo-L-tyrosine;N3-Pen-Dde;Zimeldine-d6;Ornidazole diol;Nylidrin hydrochloride;PFI-653;N-Arachidonoyl Taurine-d4;OVA Peptide (323-339);((3-Fluorophenyl)sulfonyl)glycine;7ß-Hydroxycholesterol-d7;MALAT1-IN-1;Sibiricose A1;Mefruside-d3;Ethacrynic acid mercapturate-d3;FLAG […]

For research use only. We do not sell to patients. MRS2395 CAS No. : 491611-55-3 Biological Activity：MRS2395, an dipivaloyl derivative, is a potent P2Y12 receptor antagonist. MRS2395 inhibits ADP-induced platelet activation with a Ki of 3.6 μM. MRS2395 inhibits cAMP induced by ADP in rat platelets in the presence of PGE1 with an IC50 of […]

For research use only. We do not sell to patients. Canrenone-d6 Biological Activity：Canrenone-d6 (Aldadiene-d6) is the deuterium labeled Canrenone. Canrenone (Aldadiene) is an aldosterone antagonist extensively used as a diuretic agent. Research Area：Cardiovascular Disease Targets：Mineralocorticoid Receptor|Endogenous Metabolite Related Small Molecules:D-α-Hydroxyglutaric acid disodium;Nicotinamide N-oxide;3-Hydroxyglutaric acid-d5;DPPC-d62;SDMA-d6;2-Mercaptobenzothiazole;N-Acetyl-L-glutamic acid-d5;(3R,5S)-3-Hydroxy Cotinine-d3;Biliverdin hydrochloride;D-Glucose-13C,d1-3;2,3-Diaminopropionic acid hydrochloride;Docosanoic acid-d3;Choline-d6 chloride;Pregnenolone monosulfate sodium;25-Hydroxycholesterol-d6;Pyrroloquinoline quinone;Roridin L2;NAPQI;Imidazole;Adipokinetic […]

For research use only. We do not sell to patients. rac Timolol-d5 maleate CAS No. : 1217260-21-3 Biological Activity：(Rac)-Timolol-d5 Maleate ((Rac)-L-714,465-d5 Maleate) is a labelled racemic (S)-Timolol maleate. (S)-Timolol Maleate (L-714,465 Maleate) is a non-cardioselective hydrophilic β-adrenoceptor blocker. (S)-Timolol Maleate is widely used as standard medication for intraocular pressure (glaucoma) by preventing the production of […]

For research use only. We do not sell to patients. Istradefylline CAS No. : 155270-99-8 Biological Activity：Istradefylline is a very potent, selective and orally active adenosine A2A receptor antagonist with Ki of 2.2 nM in experimental models of Parkinson’s disease. Research Area：Neurological Disease Targets：Adenosine Receptor Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved […]

For research use only. We do not sell to patients. Ticagrelor CAS No. : 274693-27-5 Biological Activity：Ticagrelor (AZD6140) is a reversible oral P2Y12 receptor antagonist for the treatment of platelet aggregation. Research Area：Cardiovascular Disease|Cancer Targets：P2Y Receptor Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;GPCR/G Protein Compound Library;FDA-Approved […]

For research use only. We do not sell to patients. 5-HT3 antagonist 5 CAS No. : 901599-43-7 Biological Activity：5-HT3 antagonist 5 is a quinoxalin-2-carboxamide compound, a 5-HT3 receptor antagonist. 5-HT3 antagonist 5 exerts antagonism on 5-HT3 agonist and 2-methyl-5-HT, and shows anti-depressant effect in mice. Research Area：Neurological Disease Targets：5-HT Receptor Related Screening Libraries:Bioactive Compound Library […]

For research use only. We do not sell to patients. BI 639667 CAS No. : 1295298-26-8 Biological Activity：BI 639667 (compound 19n), a third azaindazole series compound, is a CCR1 antagonist, with an IC50 of 1.8 nM in Ca2+ flux assay. Research Area：Inflammation/Immunology|Endocrinology Targets：CCR Related Screening Libraries:Clinical Compound Library Plus;Bioactive Compound Library Plus;GPCR/G Protein Compound Library;Immunology/Inflammation […]