Tag: Antagonist

For research use only. We do not sell to patients. p-Hydroxybenzaldehyde-13C CAS No. : 152404-52-9 Biological Activity：p-Hydroxybenzaldehyde-13C is the 13C-labeled p-Hydroxybenzaldehyde. p-Hydroxybenzaldehyde is a one of the major components in Dendrocalamus asper bamboo shoots, with antagonistic effect on GABAA receptor of the α1β2γ2S subtype at high concentrations. Research Area：Neurological Disease Targets：GABA Receptor|Endogenous Metabolite Related Small […]

For research use only. We do not sell to patients. Rolapitant CAS No. : 552292-08-7 Biological Activity：Rolapitant (SCH619734) is a potent, selective, long-acting and orally active neurokinin 1 (NK1) receptor antagonist with a Ki of 0.66 nM. Rolapitant does not interact with CYP3A4. Rolapitant shows potent anti-emetic activity in a ferret emesis model[2]. Research Area：Cancer|Neurological […]

For research use only. We do not sell to patients. Atenolol-d7 CAS No. : 1202864-50-3 Biological Activity：Atenolol-d7 ((RS)-Atenolol-d7) is the deuterium labeled Atenolol. Atenolol ((RS)-Atenolol) is a cardioselective β1-adrenergic receptor blocker, with a Ki of 697 nM atβ1-adrenoceptor in guine pig left ventricle membrane. Atenolol can be used for the research of hypertension and angina […]

For research use only. We do not sell to patients. Tecastemizole CAS No. : 75970-99-9 Biological Activity：Tecastemizole (Norastemizole), a major metabolite of Astemizole, is a potent and selective H1 receptor antagonist. Tecastemizole shows anti-inflammatory activities. Research Area：Inflammation/Immunology Targets：Histamine Receptor Related Screening Libraries:Bioactive Compound Library Plus;GPCR/G Protein Compound Library;Immunology/Inflammation Compound Library;Neuronal Signaling Compound Library;Neurotransmitter Receptor Compound […]

For research use only. We do not sell to patients. Famotidine-13C,d3 CAS No. : 2744683-81-4 Biological Activity：Famotidine-13C,d3 is the 13C- and deuterium labeled Famotidine. Famotidine (MK-208) is a competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion. Research Area：Metabolic Disease|Endocrinology Targets：Histamine Receptor Related Small Molecules:Tripelennamine;Brompheniramine-d6 maleate;Samelisant;Chlorphenoxamine;H3 receptor-MO-1;Diphenhydramine;ABT-239;Ketotifen fumarate;Ranitidine;Cetirizine;Diphenylpyraline hydrochloride;Loratadine-d5;Phenyltoloxamine;Ritanserin;BMY-25271;FRG8701;Mecamylamine hydrochloride;Cimetidine […]

For research use only. We do not sell to patients. NBI-27914 CAS No. : 184241-44-9 Biological Activity：NBI-27914 is a potent and selective antagonist of CRFR1. The CRF receptors, CRFR1 and CRFR2, are members of the G protein-coupled receptor superfamily. Research Area：Others Targets：CRFR Related Small Molecules:Stresscopin-related peptide (human);Sauvagine;CRF(6-33)(human) TFA;Urocortin III, mouse;Emicerfont;R121919;CP 316311;Pexacerfont;Urotensin I TFA;Urocortin, rat TFA;Urocortin […]

For research use only. We do not sell to patients. MPPG CAS No. : 169209-65-8 Biological Activity：MPPG is a potent and selective L-AP4-sensitive receptor antagonist with an kD value of 9.2 μM, being tested on the neonatal rat spinal cord. Research Area：Neurological Disease Targets：mGluR Related Small Molecules:LY3020371 hydrochloride;ZJ43;FPTQ;(S)-MCPG;mGluR2 modulator 1;VU6010572;Mavoglurant racemate;DFMTI;JNJ16259685;Auglurant;FITM;(-)-Camphoric acid;LY367385 hydrochloride;Cinnabarinic acid;LY379268;AZD 9272;mGluR2 […]

For research use only. We do not sell to patients. Dexetimide CAS No. : 21888-98-2 Biological Activity：Dexetimide ((+)-Benzetimide; (S)-(+)-Dexetimide; Dexbenzetimide) is a piperidine anticholinergic and a high-affinity muscarinic receptor antagonist. Dexetimide can be used in studies of parkinson’s disease[2]. Research Area：Neurological Disease Targets：mAChR Related Screening Libraries:Bioactive Compound Library Plus;GPCR/G Protein Compound Library;Neuronal Signaling Compound Library;Neurotransmitter […]

For research use only. We do not sell to patients. MeTC7 CAS No. : 1817841-22-7 Biological Activity：MeTC7 is a Vitamin-D receptor (VDR) antagonist. MeTC7 has potent VDR inhibition activity with an IC50 value of 2.9 μM. MeTC7 shows good antitumor effects. Research Area：Cancer Targets：VD/VDR Related Small Molecules:Atocalcitol;VD3-d6;Dihydrotachysterol;Tacalcitol;Impurity F of Calcipotriol;(24R)-MC 976;VDR agonist 1;TEI-9648;CB1151;MC 1046;1alpha, 25-Dihydroxy […]

For research use only. We do not sell to patients. Umeclidinium bromide CAS No. : 869113-09-7 Biological Activity：Umeclidinium bromide is a novel mAChR antagonist. The affinity (Ki) of Umeclidinium bromide for the cloned human M1-M5 mAChRs ranges from 0.05 to 0.16 nM. Research Area：Inflammation/Immunology Targets：mAChR Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved […]